{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,1]],"date-time":"2026-06-01T09:10:04Z","timestamp":1780305004976,"version":"3.54.0"},"reference-count":24,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2026,3,12]],"date-time":"2026-03-12T00:00:00Z","timestamp":1773273600000},"content-version":"vor","delay-in-days":11,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,3,1]],"date-time":"2026-03-01T00:00:00Z","timestamp":1772323200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Chem Biol Drug Des"],"published-print":{"date-parts":[[2026,3]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    In this study, novel triazole derivatives were designed and synthesized for potential breast cancer treatment. A series of 1,2,4\u2010triazole compounds bearing a 2,4\u2010difluorophenyl moiety (\n                    <jats:bold>3a\u20133r<\/jats:bold>\n                    ) was obtained through a two\u2010step organic synthesis process. The anticancer activities of the synthesized compounds were evaluated using the MTT assay in MCF\u20107 and L929 cell lines, and some derivatives (\n                    <jats:bold>3d, 3h, 3k, 3n<\/jats:bold>\n                    ) exhibited selective cytotoxicity. The inhibitory effects of these compounds on the aromatase enzyme were determined and compared with those of letrozole. Molecular docking studies were performed to investigate the interactions of the most active compounds with the aromatase enzyme's active site, revealing binding energies and amino acid interactions. Finally, the ADME profiles of the lead compounds were assessed to analyze their pharmacokinetic properties. The findings suggest that the selected triazole derivatives may be promising novel candidates for aromatase inhibition in breast cancer therapy.\n                  <\/jats:p>","DOI":"10.1111\/cbdd.70276","type":"journal-article","created":{"date-parts":[[2026,3,13]],"date-time":"2026-03-13T05:56:11Z","timestamp":1773381371000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Design and Synthesis of New Triazol Derivatives as Aromatase Enzyme Inhibitors"],"prefix":"10.1111","volume":"107","author":[{"given":"Abdullah","family":"\u00c7elik","sequence":"first","affiliation":[{"name":"Department of Pharmacy Eski\u015fehir Osmangazi Un\u0131versity Health, Practice and Research Hospital  Eskisehir Turkey"},{"name":"Institute of Graduate Education Anadolu University  Eskisehir Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hayrani Eren","family":"Bostanc\u0131","sequence":"additional","affiliation":[{"name":"Department of Biochemistry Sivas Sivas Cumhuriyet University, Faculty of Pharmacy  Sivas Turkiye"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2026-2924","authenticated-orcid":false,"given":"\u015eennur","family":"G\u00f6rg\u00fcl\u00fc","sequence":"additional","affiliation":[{"name":"Medicinal Plant, Drug and Scientific Research and Application Center (AUBIBAM)  Eski\u015fehir Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mehmet Taha","family":"Y\u0131ld\u0131z","sequence":"additional","affiliation":[{"name":"Hamidiye Faculty of Health Sciences University of Health Sciences  Istanbul Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1879-1034","authenticated-orcid":false,"given":"Ulviye","family":"Acar \u00c7evik","sequence":"additional","affiliation":[{"name":"Department of Pharmaceutical Chemistry, Faculty of Pharmacy Anadolu University  Eski\u015fehir Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,3,12]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrc721"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.3906\/kim-1302-11"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0039-128X(99)00104-X"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/gkae300"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.molstruc.2023.134920"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.2478\/acph\u20102020\u20100034"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.1038\/srep42717"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.jcim.1c00203"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature07614"},{"key":"e_1_2_9_11_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrc1211"},{"key":"e_1_2_9_12_1","doi-asserted-by":"publisher","DOI":"10.1186\/s43094-021-00241-3"},{"key":"e_1_2_9_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jsbmb.2024.106672"},{"key":"e_1_2_9_14_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.273.25.15458"},{"key":"e_1_2_9_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0093\u20107754(03)00302\u20106"},{"key":"e_1_2_9_16_1","doi-asserted-by":"publisher","DOI":"10.33435\/tcandtc.545369"},{"key":"e_1_2_9_17_1","doi-asserted-by":"crossref","unstructured":"Pritchett J. 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