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Nevertheless, mortality rates have been reported to decline with the advancement of novel therapeutic agents and the identification of new molecular targets. Schiff bases and triazine compounds have significant biological activity. For this purpose, new Schiff base derivative triazine compounds (\n                    <jats:bold>TrzSchf 1\u20133<\/jats:bold>\n                    ) were synthesized in our study. The activities of the new compounds, characterized by spectroscopic techniques, against A549 lung cancer and MRC5 normal lung cells were identified in a series of studies. It was observed that\n                    <jats:bold>TrzSchf 1\u20133<\/jats:bold>\n                    generally showed a growth\u2010inhibitory effect against lung cancer cells (A549) and a non\u2010toxic effect against normal lung cells (MRC5). Notably,\n                    <jats:bold>TrzSchf 1<\/jats:bold>\n                    and\n                    <jats:bold>TrzSchf 2, 3<\/jats:bold>\n                    exhibited prominent cytotoxic effects in A549 cells, with IC\n                    <jats:sub>50<\/jats:sub>\n                    values of 14.24 and &gt;\u200950\u2009\u03bcM, respectively. It was observed that the compound with the most potent cytotoxicity against lung cancer cells was\n                    <jats:bold>TrzSchf 1<\/jats:bold>\n                    (Selective Index: 3.62). In A549 cells, an increase in MAPK gene expression was observed for all compounds. It was observed that the expression of Caspase\u20103, CD40, CHK1, P27, P38, and P53 proapoptotic proteins increased by all compounds (\n                    <jats:bold>TrzSchf 1\u20133<\/jats:bold>\n                    ), whereas the expression of antiapoptotic proteins such as BCL\u20102 and NF\u03baB decreased by these compounds. The compounds are thought to be potential inhibitors of BCL\u20102 and NF\u03baB, which are associated with cell death. Complementary and guiding\n                    <jats:italic>in silico<\/jats:italic>\n                    studies supported the experimental findings. BCL\u20102 was determined as the most favorable molecular target based on docking scores, and e\u2010pharmacophore modeling further revealed key interaction features and enabled SAR analysis. The drug\u2010likeness potential of the\n                    <jats:bold>TrzSchf<\/jats:bold>\n                    derivatives was evaluated based on Lipinski's Rule of Five parameters. Overall, both experimental and computational results suggest that\n                    <jats:bold>TrzSchf 1\u20133<\/jats:bold>\n                    are promising lead candidates for further investigation in lung cancer therapy.\n                  <\/jats:p>","DOI":"10.1111\/cbdd.70278","type":"journal-article","created":{"date-parts":[[2026,3,30]],"date-time":"2026-03-30T15:02:26Z","timestamp":1774882946000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["New Schiff Base Derivative Triazines: Their Synthesis, Molecular Docking Studies, and Anticancer Activities in Human Lung Cancer Cells"],"prefix":"10.1111","volume":"107","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3579-8062","authenticated-orcid":false,"given":"Elif","family":"\u015eenkuytu","sequence":"first","affiliation":[{"name":"Department of Chemistry, Science of Faculty Atat\u00fcrk University  Erzurum 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