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The anticancer properties of the synthesized compounds were investigated, along with a complementary study evaluating their antioxidant and antimicrobial properties. The cytotoxicity screening against HCT116 and PANC1 cancer cell lines revealed generally low antiproliferative effects; however, compounds\n                    <jats:bold>6c<\/jats:bold>\n                    and\n                    <jats:bold>6e<\/jats:bold>\n                    demonstrated relatively higher pro\u2010apoptotic potential in HCT116 cells compared to the other compounds. In assays evaluating antioxidant capacity, utilizing both CUPRAC and DPPH methods, all synthesized compounds exhibited activity ranging from moderate to good. Notably, compound\n                    <jats:bold>6l<\/jats:bold>\n                    demonstrated the strongest antioxidant performance with TEAC\u2009=\u20091.34 and IC\n                    <jats:sub>50<\/jats:sub>\n                    \u2009=\u20090.084\u2009\u00b1\u20090.003\u2009mmol\u2009L\n                    <jats:sup>\u22121<\/jats:sup>\n                    . Furthermore, among the tested compounds,\n                    <jats:bold>6a<\/jats:bold>\n                    ,\n                    <jats:bold>6b<\/jats:bold>\n                    , and\n                    <jats:bold>6d<\/jats:bold>\n                    displayed good antibacterial activity against\n                    <jats:styled-content style=\"fixed-case\">\n                      <jats:italic>Staphylococcus aureus<\/jats:italic>\n                    <\/jats:styled-content>\n                    with a minimum inhibitory concentration (MIC) of 19.53\u2009\u03bcg\/mL.\n                  <\/jats:p>","DOI":"10.1111\/cbdd.70344","type":"journal-article","created":{"date-parts":[[2026,6,20]],"date-time":"2026-06-20T05:45:04Z","timestamp":1781934304000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Design, Synthesis, and Biological Evaluation of Novel\n                    <i>N<\/i>\n                    \u2010Acyl 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