{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,26]],"date-time":"2026-06-26T14:49:15Z","timestamp":1782485355534,"version":"3.54.5"},"reference-count":42,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2026,6,23]],"date-time":"2026-06-23T00:00:00Z","timestamp":1782172800000},"content-version":"vor","delay-in-days":22,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,6,1]],"date-time":"2026-06-01T00:00:00Z","timestamp":1780272000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Chem Biol Drug Des"],"published-print":{"date-parts":[[2026,6]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    A novel series of thiazolyl\u2013pyrazoline derivatives (MAP\u20101 to MAP\u201020) was designed and synthesized as potential epidermal growth factor receptor (EGFR) inhibitors. The structures of all compounds were confirmed by\n                    <jats:sup>1<\/jats:sup>\n                    H NMR,\n                    <jats:sup>13<\/jats:sup>\n                    C NMR, and HRMS analyses. The synthesized derivatives were evaluated for in\u00a0vitro anticancer activity using the MTT assay against MCF\u20107 (breast), A549 (lung), HeLa (cervical), and non\u2010tumorigenic MCF\u201010A cell lines. Among the tested compounds, MAP\u201013, MAP\u201015, and MAP\u201019 exhibited potent cytotoxic activity against MCF\u20107 (IC\n                    <jats:sub>50<\/jats:sub>\n                    \u2009=\u20091.09\u2009\u00b1\u20090.8, 2.33\u2009\u00b1\u20090.84, and 2.11\u2009\u00b1\u20090.26\u2009\u03bcM, respectively), A549 (IC\n                    <jats:sub>50<\/jats:sub>\n                    \u2009=\u20092.06\u2009\u00b1\u20090.16, 2.81\u2009\u00b1\u20090.16, and 2.76\u2009\u00b1\u20090.42\u2009\u03bcM, respectively), and HeLa cells (IC\n                    <jats:sub>50<\/jats:sub>\n                    \u2009=\u20091.18\u2009\u00b1\u20090.9, 2.27\u2009\u00b1\u20090.18, and 2.15\u2009\u00b1\u20090.36\u2009\u03bcM, respectively), with improved selectivity over normal MCF\u201010A cells. Molecular docking studies against EGFR (PDB ID: 4I23) revealed strong binding affinities, with docking scores of \u22128.67, \u22129.31, and \u22129.00\u2009kcal\/mol for MAP\u201013, MAP\u201015, and MAP\u201019, respectively. Key interactions within the ATP\u2010binding pocket suggested stable ligand\u2013receptor complex formation. In silico ADMET profiling confirmed acceptable drug\u2010likeness and pharmacokinetic properties for the lead compounds. These findings indicate that thiazolyl\u2013pyrazoline hybrids represent promising scaffolds for the development of selective EGFR\u2010targeted anticancer agents.\n                  <\/jats:p>","DOI":"10.1111\/cbdd.70345","type":"journal-article","created":{"date-parts":[[2026,6,24]],"date-time":"2026-06-24T05:30:36Z","timestamp":1782279036000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Design, Synthesis, Biological Evaluation, and Molecular Docking of Novel Thiazolyl\u2013Pyrazoline Derivatives as Potential\n                    <scp>EGFR<\/scp>\n                    Inhibitors"],"prefix":"10.1111","volume":"107","author":[{"ORCID":"https:\/\/orcid.org\/0009-0008-5340-2982","authenticated-orcid":false,"given":"Mayuri A.","family":"Patil","sequence":"first","affiliation":[{"name":"Department of Chemical Technology Dr. Babasaheb Ambedkar Marathwada University  Chhatrapati Sambhajinagar Maharashtra India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sachin S.","family":"Bhusari","sequence":"additional","affiliation":[{"name":"Department of Chemical Technology Dr. Babasaheb Ambedkar Marathwada University  Chhatrapati Sambhajinagar Maharashtra India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pravin S.","family":"Wakte","sequence":"additional","affiliation":[{"name":"Department of Chemical Technology Dr. Babasaheb Ambedkar Marathwada University  Chhatrapati Sambhajinagar Maharashtra India"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,6,23]]},"reference":[{"key":"e_1_2_12_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejmech.2016.04.049"},{"key":"e_1_2_12_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bioorg.2019.03.076"},{"key":"e_1_2_12_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bioorg.2022.106171"},{"key":"e_1_2_12_5_1","doi-asserted-by":"publisher","DOI":"10.21203\/rs.3.rs\u20101243512\/v1"},{"key":"e_1_2_12_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejmech.2019.111784"},{"key":"e_1_2_12_7_1","doi-asserted-by":"publisher","DOI":"10.22159\/ajpcr.2017.v10i12.22065"},{"key":"e_1_2_12_8_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00044\u2010019\u201002434\u20101"},{"key":"e_1_2_12_9_1","doi-asserted-by":"publisher","DOI":"10.1007\/s13738\u2010019\u201001633\u20102"},{"key":"e_1_2_12_10_1","doi-asserted-by":"publisher","DOI":"10.1080\/00397911.2018.1480042"},{"key":"e_1_2_12_11_1","doi-asserted-by":"publisher","DOI":"10.1080\/07391102.2021.1965912"},{"key":"e_1_2_12_12_1","doi-asserted-by":"publisher","DOI":"10.1002\/ejoc.201601221"},{"key":"e_1_2_12_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jscs.2023.101669"},{"key":"e_1_2_12_14_1","doi-asserted-by":"publisher","DOI":"10.1517\/17460441.2015.1032936"},{"key":"e_1_2_12_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bioorg.2018.10.038"},{"key":"e_1_2_12_16_1","doi-asserted-by":"publisher","DOI":"10.20959\/wjpps20176\u20109343"},{"key":"e_1_2_12_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bioorg.2022.106273"},{"key":"e_1_2_12_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.str.2013.08.020"},{"key":"e_1_2_12_19_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41392\u2010020\u201000451\u2010w"},{"key":"e_1_2_12_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejmech.2022.114889"},{"key":"e_1_2_12_21_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bioorg.2020.104612"},{"key":"e_1_2_12_22_1","doi-asserted-by":"publisher","DOI":"10.1021\/ci300604z"},{"key":"e_1_2_12_23_1","doi-asserted-by":"publisher","DOI":"10.1158\/0008\u20105472.can\u201005\u20101182"},{"key":"e_1_2_12_24_1","doi-asserted-by":"publisher","DOI":"10.1002\/prot.23106"},{"key":"e_1_2_12_25_1","doi-asserted-by":"publisher","DOI":"10.2174\/1570162X19666210915102230"},{"key":"e_1_2_12_26_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bmcl.2021.127827"},{"key":"e_1_2_12_27_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bmc.2007.07.052"},{"key":"e_1_2_12_28_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.molstruc.2022.134633"},{"key":"e_1_2_12_29_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bmcl.2011.07.010"},{"key":"e_1_2_12_30_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejmech.2019.05.006"},{"key":"e_1_2_12_31_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.molstruc.2023.135589"},{"key":"e_1_2_12_32_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijgo.2008.04.008"},{"key":"e_1_2_12_33_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejmech.2019.111648"},{"key":"e_1_2_12_34_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.jmedchem.6b01367"},{"key":"e_1_2_12_35_1","doi-asserted-by":"publisher","DOI":"10.1080\/10406638.2022.2150238"},{"key":"e_1_2_12_36_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bmcl.2022.128747"},{"key":"e_1_2_12_37_1","doi-asserted-by":"publisher","DOI":"10.3390\/molecules22060995"},{"key":"e_1_2_12_38_1","doi-asserted-by":"publisher","DOI":"10.1021\/jm020017n"},{"key":"e_1_2_12_39_1","doi-asserted-by":"publisher","DOI":"10.2147\/DDDT.S356988"},{"key":"e_1_2_12_40_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms19113491"},{"key":"e_1_2_12_41_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bmcl.2019.126914"},{"key":"e_1_2_12_42_1","doi-asserted-by":"publisher","DOI":"10.1038\/35052073"},{"key":"e_1_2_12_43_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.molstruc.2022.134670"}],"container-title":["Chemical Biology &amp; Drug Design"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/cbdd.70345","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/cbdd.70345","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/cbdd.70345","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,6,26]],"date-time":"2026-06-26T14:15:07Z","timestamp":1782483307000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/cbdd.70345"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,6]]},"references-count":42,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2026,6]]}},"alternative-id":["10.1111\/cbdd.70345"],"URL":"https:\/\/doi.org\/10.1111\/cbdd.70345","archive":["Portico"],"relation":{},"ISSN":["1747-0277","1747-0285"],"issn-type":[{"value":"1747-0277","type":"print"},{"value":"1747-0285","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,6]]},"assertion":[{"value":"2026-02-25","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-06-12","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-06-23","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e70345"}}