{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,27]],"date-time":"2026-08-27T09:21:11Z","timestamp":1787822471171,"version":"build-2784847793"},"reference-count":35,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2026,8,10]],"date-time":"2026-08-10T00:00:00Z","timestamp":1786320000000},"content-version":"vor","delay-in-days":9,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,8,1]],"date-time":"2026-08-01T00:00:00Z","timestamp":1785542400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100004775","name":"Natural Science Foundation of Gansu Province","doi-asserted-by":"publisher","award":["22JR5RA582"],"award-info":[{"award-number":["22JR5RA582"]}],"id":[{"id":"10.13039\/501100004775","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004775","name":"Natural Science Foundation of Gansu Province","doi-asserted-by":"publisher","award":["2023A\u2010088"],"award-info":[{"award-number":["2023A\u2010088"]}],"id":[{"id":"10.13039\/501100004775","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004775","name":"Natural Science Foundation of Gansu Province","doi-asserted-by":"publisher","award":["5.2023A\u2010088"],"award-info":[{"award-number":["5.2023A\u2010088"]}],"id":[{"id":"10.13039\/501100004775","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Chem Biol Drug Des"],"published-print":{"date-parts":[[2026,8]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    S\u2010palmitoylation is a crucial post\u2010translational modification that regulates diverse cellular processes, particularly signalling pathways. The ZDHHC family of enzymes catalyzes this modification, however, the role of ZDHHC16 in cancer warrants in\u2010depth investigation. This study presents a comprehensive pan\u2010cancer analysis of ZDHHC16, examining its expression patterns, clinical relevance, associations with immune responses, genomic characteristics, and potential as a therapeutic target. We further analysed single\u2010cell and spatial transcriptomic data to identify specific cell populations associated with ZDHHC16 dysregulation. Our findings reveal that ZDHHC16 dysregulation is tissue\u2010specific and promotes tumor progression and modulates immune responses, highlighting its potential as a therapeutic target in several cancers, including ACC and BRCA. In ACC and BRCA, high ZDHHC16 expression correlates with shorter overall survival (\n                    <jats:italic>p<\/jats:italic>\n                    \u2009&lt;\u20090.001) and regulates PD\u2010L1 expression.\n                  <\/jats:p>","DOI":"10.1111\/cbdd.70355","type":"journal-article","created":{"date-parts":[[2026,8,10]],"date-time":"2026-08-10T07:00:50Z","timestamp":1786345250000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Pan\u2010Cancer Multi\u2010Omics Analysis Reveals the Potential of\n                    <scp>ZDHHC16<\/scp>\n                    in Tumor Progression and Immune Regulation"],"prefix":"10.1111","volume":"108","author":[{"given":"Haolong","family":"Zhang","sequence":"first","affiliation":[{"name":"School of Public Health Gansu University of Chinese Medicine  Lanzhou Gansu China"},{"name":"The First Affiliated Hospital of Henan Medical University  Xinxiang Henan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sen","family":"Wu","sequence":"additional","affiliation":[{"name":"The First Affiliated Hospital of Henan Medical University  Xinxiang Henan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yufei","family":"Ma","sequence":"additional","affiliation":[{"name":"The First Affiliated Hospital of Henan Medical University  Xinxiang Henan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yufei","family":"Yang","sequence":"additional","affiliation":[{"name":"School of Public Health Gansu University of Chinese Medicine  Lanzhou Gansu China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yixin","family":"Zhang","sequence":"additional","affiliation":[{"name":"The First Affiliated Hospital of Henan Medical University  Xinxiang Henan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xue Hai","family":"Liu","sequence":"additional","affiliation":[{"name":"School of Public Health Gansu University of Chinese Medicine  Lanzhou Gansu China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Haoling","family":"Zhang","sequence":"additional","affiliation":[{"name":"Advanced Medical and Dental Institute Universiti Sains Malaysia  Kepala Batas Penang Malaysia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zheng","family":"Zhang","sequence":"additional","affiliation":[{"name":"The First Affiliated Hospital of Henan Medical University  Xinxiang Henan China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,8,10]]},"reference":[{"key":"e_1_2_13_2_1","doi-asserted-by":"publisher","DOI":"10.7554\/eLife.27826"},{"key":"e_1_2_13_3_1","doi-asserted-by":"publisher","DOI":"10.3389\/fcell.2021.626404"},{"key":"e_1_2_13_4_1","doi-asserted-by":"publisher","DOI":"10.1074\/mcp.RA118.001260"},{"key":"e_1_2_13_5_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41587\u2010020\u20100546\u20108"},{"key":"e_1_2_13_6_1","doi-asserted-by":"publisher","DOI":"10.1002\/imt2.43"},{"key":"e_1_2_13_7_1","doi-asserted-by":"publisher","DOI":"10.1186\/1471\u20102105\u201014\u20107"},{"key":"e_1_2_13_8_1","doi-asserted-by":"publisher","DOI":"10.1158\/1078\u20100432.Ccr\u201015\u20101507"},{"key":"e_1_2_13_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2018.03.022"},{"key":"e_1_2_13_10_1","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/28.1.27"},{"key":"e_1_2_13_11_1","doi-asserted-by":"publisher","DOI":"10.1002\/INMD.20250016"},{"key":"e_1_2_13_12_1","doi-asserted-by":"publisher","DOI":"10.1042\/bst20160303"},{"key":"e_1_2_13_13_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12903\u2010024\u201004107\u2010x"},{"key":"e_1_2_13_14_1","doi-asserted-by":"publisher","DOI":"10.14715\/cmb\/2024.70.2.5"},{"key":"e_1_2_13_15_1","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2025.1640016"},{"key":"e_1_2_13_16_1","doi-asserted-by":"publisher","DOI":"10.12688\/f1000research.16409.2"},{"key":"e_1_2_13_17_1","doi-asserted-by":"publisher","DOI":"10.1098\/rsob.210026"},{"key":"e_1_2_13_18_1","doi-asserted-by":"publisher","DOI":"10.1101\/gr.239244.118"},{"key":"e_1_2_13_19_1","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/gkv1045"},{"key":"e_1_2_13_20_1","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/gkv007"},{"key":"e_1_2_13_21_1","doi-asserted-by":"publisher","DOI":"10.1186\/1471\u20102105\u201012\u201077"},{"key":"e_1_2_13_22_1","doi-asserted-by":"publisher","DOI":"10.1242\/jcs.251819"},{"key":"e_1_2_13_23_1","doi-asserted-by":"publisher","DOI":"10.1158\/0008\u20105472.Can\u201023\u20102650"},{"key":"e_1_2_13_24_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.aay5947"},{"key":"e_1_2_13_25_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.immuni.2018.03.014"},{"key":"e_1_2_13_26_1","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/gkaa1020"},{"key":"e_1_2_13_27_1","doi-asserted-by":"publisher","DOI":"10.1158\/0008\u20105472.Can\u201022\u20103105"},{"key":"e_1_2_13_28_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1467\u20109868.2011.01004.x"},{"key":"e_1_2_13_29_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.clnves.2025.100032"},{"key":"e_1_2_13_30_1","doi-asserted-by":"publisher","DOI":"10.1002\/mdr2.70048"},{"key":"e_1_2_13_31_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41467\u2010023\u201036560\u20107"},{"key":"e_1_2_13_32_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41422\u2010018\u20100124\u20105"},{"key":"e_1_2_13_33_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M112.362095"},{"key":"e_1_2_13_34_1","doi-asserted-by":"publisher","DOI":"10.1089\/omi.2011.0118"},{"key":"e_1_2_13_35_1","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/gky939"},{"key":"e_1_2_13_36_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41467\u2010021\u201026180\u20104"}],"container-title":["Chemical Biology &amp; Drug Design"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/cbdd.70355","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/cbdd.70355","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/cbdd.70355","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,8,27]],"date-time":"2026-08-27T08:54:34Z","timestamp":1787820874000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/cbdd.70355"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,8]]},"references-count":35,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2026,8]]}},"alternative-id":["10.1111\/cbdd.70355"],"URL":"https:\/\/doi.org\/10.1111\/cbdd.70355","archive":["Portico"],"relation":{},"ISSN":["1747-0277","1747-0285"],"issn-type":[{"value":"1747-0277","type":"print"},{"value":"1747-0285","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,8]]},"assertion":[{"value":"2025-10-22","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-06-01","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-08-10","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e70355"}}