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It is of interest to pharmaceutical chemists because of their chemotherapeutic effect profiles such as antibacterial, antifungal, antiviral, and anticancer; briefly, their cytotoxic effects are very interesting. Because of these cytotoxic activities, in this project, we synthesized chalcone derivatives from the 5\n                    <jats:sup>th<\/jats:sup>\n                    position of the thiazolidin\u20104\u2010one and its linking pyridine by the hydrazone bridge. The antibacterial activities of the resulted compounds on different gram (+) and (\u2212) bacteria and their antifungal activities tested against several invasive fungi. Due to significant fungistatic activity, the inhibitory activity on lanosterol demethylase (LDM, 5TZ1, CYP51A1) and aromatase (3EQM, CYP19A1) enzymes was evaluated, and in silico approaches were used to clarify and explain the binding modes, and then the structure activity relationship (SAR) was reported. Results of the study indicated that designed molecules were successfully obtained with important antifungal activity, and the mechanism of action was clarified.\n                  <\/jats:p>","DOI":"10.1111\/cbdd.70356","type":"journal-article","created":{"date-parts":[[2026,7,10]],"date-time":"2026-07-10T09:40:33Z","timestamp":1783676433000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Design, Synthesis of Pyridine Based Thiazolidine Derivatives and Investigation of Antimicrobial Activity Targeting Ergosterol Biosynthesis via In\u00a0Vitro and In Silico Approaches"],"prefix":"10.1111","volume":"108","author":[{"ORCID":"https:\/\/orcid.org\/0009-0002-1614-2380","authenticated-orcid":false,"given":"Ayb\u00fcke Z\u00fcleyha","family":"Kaya","sequence":"first","affiliation":[{"name":"Department of Pharmaceutical Chemistry Faculty of Pharmacy, Anadolu University  Eskisehir Turkey"},{"name":"Department of Pharmaceutical Chemistry, Graduate School Anadolu University  Eskisehir Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8651-826X","authenticated-orcid":false,"given":"Asaf Evrim","family":"Evren","sequence":"additional","affiliation":[{"name":"Department of Pharmaceutical Chemistry Faculty of Pharmacy, Anadolu University  Eskisehir Turkey"},{"name":"Department of Pharmacy Services, Vocational School of Health Services Bilecik \u015eeyh Edebali University  Bilecik Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6443-1633","authenticated-orcid":false,"given":"\u00dclk\u00fcye Dudu","family":"G\u00fcl","sequence":"additional","affiliation":[{"name":"Department of Bioengineering Faculty of Engineering, Bilecik \u015eeyh Edebali University  Bilecik Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5233-1165","authenticated-orcid":false,"given":"Halide Edip","family":"Temel","sequence":"additional","affiliation":[{"name":"Department of Biochemistry Faculty of Pharmacy, Anadolu University  Eskisehir Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0957-6044","authenticated-orcid":false,"given":"Leyla","family":"Yurtta\u015f","sequence":"additional","affiliation":[{"name":"Department of Pharmaceutical Chemistry Faculty of Pharmacy, Anadolu University  Eskisehir Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,7,10]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.3390\/molecules27196368"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.3390\/ph17121632"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.1080\/1062936X.2022.2149620"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.3390\/molecules28041925"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10637\u2010006\u20109024\u20105"},{"key":"e_1_2_10_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.molstruc.2023.135157"},{"key":"e_1_2_10_8_1","doi-asserted-by":"publisher","DOI":"10.3390\/molecules27217647"},{"key":"e_1_2_10_9_1","doi-asserted-by":"publisher","DOI":"10.3390\/antibiotics12020285"},{"key":"e_1_2_10_10_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.jmedchem.2c00668"},{"key":"e_1_2_10_11_1","doi-asserted-by":"publisher","DOI":"10.1086\/595011"},{"key":"e_1_2_10_12_1","doi-asserted-by":"publisher","DOI":"10.1021\/acsomega.2c06142"},{"key":"e_1_2_10_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejmech.2022.114562"},{"key":"e_1_2_10_14_1","volume-title":"Methods for Dilution Antimicrobial Susceptibility Tests for Bacteria That Grow Aerobically; Approved Standard\u2014Ninth Edition","author":"CLSI","year":"2012"},{"key":"e_1_2_10_15_1","unstructured":"Confgen.(2020). 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