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Thus, the pharmacokinetic profile of two potential leads against visceral leishmaniasis was assessed in\u00a0vitro. Both lead candidates\n                    <jats:bold>1<\/jats:bold>\n                    and\n                    <jats:bold>2<\/jats:bold>\n                    exhibited a satisfactory ADME profile, with\n                    <jats:bold>2<\/jats:bold>\n                    proving slightly superior in terms of metabolic stability. Therefore, after complementary toxicity assessment which revealed that\n                    <jats:bold>2<\/jats:bold>\n                    did not exert hepatotoxicity in\u00a0vitro or acute toxicity in\u00a0vivo, the evaluation of its efficacy in a mouse model highlighted that\n                    <jats:bold>2<\/jats:bold>\n                    indeed displays antileishmanial efficacy in\u00a0vivo. Albeit moderate at a dose of 50\u2009mg\/kg\/day, its efficacy increased at a dose of 100\u2009mg\/kg\/day, reducing the parasite burden by 90% in the spleen of infected mice, though safety concerns were raised at this dose. In\u00a0vitro investigation of its mode of action revealed that\n                    <jats:bold>2<\/jats:bold>\n                    exerts a cytostatic effect on\n                    <jats:italic>Leishmania infantum<\/jats:italic>\n                    promastigotes, promoting cell cycle arrest during the G0\/G1 phase which may potentially be linked to the production of reactive oxygen species.\n                  <\/jats:p>","DOI":"10.1111\/cbdd.70367","type":"journal-article","created":{"date-parts":[[2026,8,4]],"date-time":"2026-08-04T13:27:51Z","timestamp":1785850071000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Identification of a Benzenesulfonylpiperazine Derivative With In\u00a0Vivo Efficacy Against Visceral Leishmaniasis"],"prefix":"10.1111","volume":"108","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2347-9515","authenticated-orcid":false,"given":"Thibault Joseph William","family":"Jacques Dit Lapierre","sequence":"first","affiliation":[{"name":"Laborat\u00f3rio de S\u00edntese de Candidatos a F\u00e1rmacos, Instituto de Qu\u00edmica Universidade Federal de Uberl\u00e2ndia (UFU)  Uberl\u00e2ndia MG Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0828-790X","authenticated-orcid":false,"given":"Mariza","family":"Gabriela Faleiro de Moura Lodi Cruz","sequence":"additional","affiliation":[{"name":"Grupo de Gen\u00f4mica Funcional de Parasitos Instituto Ren\u00e9 Rachou, Funda\u00e7\u00e3o Oswaldo Cruz (FIOCRUZ Minas)  Belo Horizonte MG Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7795-1419","authenticated-orcid":false,"given":"Guilherme","family":"Freitas de Lima Hercos","sequence":"additional","affiliation":[{"name":"Laborat\u00f3rio de S\u00edntese de Candidatos a F\u00e1rmacos, Instituto de Qu\u00edmica Universidade Federal de Uberl\u00e2ndia (UFU)  Uberl\u00e2ndia MG Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0008-4099-9986","authenticated-orcid":false,"given":"Rafael Consolin","family":"Chelucci","sequence":"additional","affiliation":[{"name":"Laborat\u00f3rio de Qu\u00edmica Medicinal e Computacional (LQMC), Instituto de F\u00edsica de S\u00e3o Carlos (IFSC) Universidade de S\u00e3o Paulo (USP)  S\u00e3o Carlos SP Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Simone","family":"Michelan\u2010Duarte","sequence":"additional","affiliation":[{"name":"Laborat\u00f3rio de Qu\u00edmica Medicinal e Computacional (LQMC), Instituto de F\u00edsica de S\u00e3o Carlos (IFSC) Universidade de S\u00e3o Paulo (USP)  S\u00e3o Carlos SP Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9431-2627","authenticated-orcid":false,"given":"Gisele","family":"Barbosa","sequence":"additional","affiliation":[{"name":"Laborat\u00f3rio de Qu\u00edmica Medicinal e Computacional (LQMC), Instituto de F\u00edsica de S\u00e3o Carlos (IFSC) Universidade de S\u00e3o Paulo (USP)  S\u00e3o Carlos SP Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4738-7508","authenticated-orcid":false,"given":"Analu R.","family":"Costa","sequence":"additional","affiliation":[{"name":"Laborat\u00f3rio de Qu\u00edmica Medicinal e Computacional (LQMC), Instituto de F\u00edsica de S\u00e3o Carlos (IFSC) Universidade de S\u00e3o Paulo (USP)  S\u00e3o Carlos SP Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8394-4802","authenticated-orcid":false,"given":"Miguel Angel","family":"Ch\u00e1vez\u2010Fumagalli","sequence":"additional","affiliation":[{"name":"Computational Biology and Chemistry Research Group, Vicerrectorado de Investigaci\u00f3n Universidad Cat\u00f3lica de Santa Mar\u00eda  Arequipa Peru"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5474-7017","authenticated-orcid":false,"given":"Paula","family":"Derksen Macruz","sequence":"additional","affiliation":[{"name":"Laborat\u00f3rio de Biomol\u00e9culas e Espectrometria de Massas (LaBioMass) Universidade Estadual de Maring\u00e1 (UEM)  Maring\u00e1 PR Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9175-3520","authenticated-orcid":false,"given":"Eduardo","family":"Jorge Pilau","sequence":"additional","affiliation":[{"name":"Laborat\u00f3rio de Biomol\u00e9culas e Espectrometria de Massas (LaBioMass) Universidade Estadual de Maring\u00e1 (UEM)  Maring\u00e1 PR Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6947-0639","authenticated-orcid":false,"given":"Leonardo L. 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