{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,27]],"date-time":"2026-08-27T09:21:12Z","timestamp":1787822472816,"version":"build-2784847793"},"reference-count":46,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2026,8,2]],"date-time":"2026-08-02T00:00:00Z","timestamp":1785628800000},"content-version":"vor","delay-in-days":1,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,8,1]],"date-time":"2026-08-01T00:00:00Z","timestamp":1785542400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Chem Biol Drug Des"],"published-print":{"date-parts":[[2026,8]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>Osteoarthritis (OA) progression is driven by inflammatory mediators and immune dysregulation within the joint. Curcumin (Cur) possesses multi\u2010target therapeutic potential. However, its clinical application is limited by poor solubility and a short half\u2010life. In this study, we developed injectable Cur\u2010loaded GelMA microspheres (Cur\u2010MS) and evaluated their effects in IL\u20101\u03b2 stimulated chondrocytes, cartilage organoids, and a monosodium iodoacetate (MIA) induced rat OA model, complemented by public transcriptomic analysis (GSE114007). The Cur\u2010MS demonstrated uniform size distribution, favorable biocompatibility, and sustained curcumin release. Treatment with Cur\u2010MS significantly reduced chondrocyte apoptosis, reactive oxygen species levels, and hypertrophic markers; restored COL\u2010II and ACAN synthesis; and downregulated MMP13 and inflammatory gene expression. In\u00a0vivo, Cur\u2010MS improved joint space, alleviated pain, decreased synovial CD68 positive macrophage infiltration and levels of IL\u20106 and TNF\u2010\u03b1, and enhanced chondrogenic gene expression. Public transcriptomic data corroborated these findings, revealing upregulation of MMP13 and downregulation of SOX9 in OA cartilage, consistent with our experimental targets. Collectively, this study provides the first multi\u2010model evidence combined with transcriptomic validation, demonstrating that Cur\u2010MS not only directly protects chondrocytes and restores extracellular matrix homeostasis but also modulates the joint inflammatory immune microenvironment. These findings suggest that Cur\u2010MS represents a promising locally sustained\u2010release therapeutic strategy for OA.<\/jats:p>","DOI":"10.1111\/cbdd.70373","type":"journal-article","created":{"date-parts":[[2026,8,3]],"date-time":"2026-08-03T09:53:46Z","timestamp":1785750826000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Curcumin\u2010Loaded\n                    <scp>GelMA<\/scp>\n                    Microspheres Alleviate Osteoarthritis: Transcriptomic Evidence for Immune Microenvironment Remodeling and\n                    <scp>ECM<\/scp>\n                    Homeostasis Restoration"],"prefix":"10.1111","volume":"108","author":[{"given":"Bin","family":"Jiang","sequence":"first","affiliation":[{"name":"Rehabilitation Department Qilu Hospital of Shandong University (Qingdao)  Qingdao Shandong 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