{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T09:56:38Z","timestamp":1790762198797,"version":"4.1.0"},"reference-count":36,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2026,9,17]],"date-time":"2026-09-17T00:00:00Z","timestamp":1789603200000},"content-version":"vor","delay-in-days":16,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T00:00:00Z","timestamp":1788220800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Chem Biol Drug Des"],"published-print":{"date-parts":[[2026,9]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    A new series of\n                    <jats:italic>N<\/jats:italic>\n                    \u2010hydroxy\u20101\u2010(4\u2010(aryl sulfonamido)phenyl)\u20101\n                    <jats:italic>H<\/jats:italic>\n                    \u20101,2,3\u2010triazole\u20104\u2010carboxamide derivatives (\n                    <jats:bold>8a<\/jats:bold>\n                    \u2010\n                    <jats:bold>j<\/jats:bold>\n                    ) were synthesized through a concise multistep route integrating three key pharmacophores: the 1,2,3\u2010triazole core, an aryl sulfonamide moiety, and an\n                    <jats:italic>N<\/jats:italic>\n                    \u2010hydroxycarboxamide group. Biological evaluation demonstrated promising antimicrobial potential for several derivatives. Compounds\n                    <jats:bold>8f<\/jats:bold>\n                    ,\n                    <jats:bold>8g<\/jats:bold>\n                    , and\n                    <jats:bold>8i<\/jats:bold>\n                    exhibited notable antibacterial activity against both Gram\u2010positive and Gram\u2010negative bacteria, whereas most analogues showed weak antifungal activity. In the antimalarial assay, compound\n                    <jats:bold>8d<\/jats:bold>\n                    emerged as the most potent derivative (IC\n                    <jats:sub>50<\/jats:sub>\n                    \u2009=\u20090.84\u2009\u03bcg\/mL), while compounds\n                    <jats:bold>8b<\/jats:bold>\n                    ,\n                    <jats:bold>8e<\/jats:bold>\n                    ,\n                    <jats:bold>8g<\/jats:bold>\n                    , and\n                    <jats:bold>8h<\/jats:bold>\n                    also displayed appreciable activity. Antitubercular evaluation identified compounds\n                    <jats:bold>8g<\/jats:bold>\n                    and\n                    <jats:bold>8i<\/jats:bold>\n                    as the most active derivatives against\n                    <jats:styled-content style=\"fixed-case\">\n                      <jats:italic>Mycobacterium tuberculosis<\/jats:italic>\n                    <\/jats:styled-content>\n                    H37Rv, with MIC values of 62.5 and 50\u2009\u03bcg\/mL, respectively. The molecular docking study against DNA gyrase (PDB ID: 7FVT) and lanosterol 14\u03b1\u2010demethylase (PDB ID: 5V5Z) as relevant antibacterial and antifungal targets, respectively, showed a similar trend of activity. Computational studies, including molecular docking, MM\/GBSA, molecular dynamics simulations, and ADME prediction, supported the structural and pharmacokinetic characteristics of the synthesized compounds, with selected derivatives exhibiting favorable interactions with the c\u2010KIT kinase active site and generally acceptable drug\u2010like properties. Overall, these triazole\u2013sulfonamide\u2013N\u2010hydroxycarboxamide hybrids represent promising lead molecules for further structural optimization and biological investigation.\n                  <\/jats:p>","DOI":"10.1111\/cbdd.70400","type":"journal-article","created":{"date-parts":[[2026,9,17]],"date-time":"2026-09-17T08:52:49Z","timestamp":1789635169000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Design and Synthesis of Novel 1,2,3\u2010Triazole Conjugates Featuring Hydroxamic Acid and Sulfonamide Moieties: Exploring Dual Pharmacophores for Enhanced Biological Activity"],"prefix":"10.1111","volume":"108","author":[{"ORCID":"https:\/\/orcid.org\/0009-0003-2377-3575","authenticated-orcid":false,"given":"Dineshkumar","family":"Pagar","sequence":"first","affiliation":[{"name":"Organic Chemistry Research Laboratory, Maharashtra Udaygiri Mahavidyalay, Swami Ramanand Teerth Marathwada University  Nanded India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2743-4303","authenticated-orcid":false,"given":"Ranjay","family":"Shaw","sequence":"additional","affiliation":[{"name":"Department of Chemistry GLA University  Mathura Uttar Pradesh India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hemant","family":"Suryavanshi","sequence":"additional","affiliation":[{"name":"Zeal College of Engineering and Research  Pune India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8118-3758","authenticated-orcid":false,"given":"Dhanji","family":"Rajani","sequence":"additional","affiliation":[{"name":"Microcare Laboratory  Surat India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sudhakar","family":"Patil","sequence":"additional","affiliation":[{"name":"Organic Chemistry Research Laboratory, Maharashtra Udaygiri Mahavidyalay, Swami Ramanand Teerth Marathwada University  Nanded India"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,9,17]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-024-62864-9"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bioorg.2024.107154"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.1039\/D4MD00302K"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13065-018-0479-1"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00044-014-1136-4"},{"key":"e_1_2_10_7_1","doi-asserted-by":"publisher","DOI":"10.1080\/07391102.2023.2291826"},{"key":"e_1_2_10_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bmcl.2023.129551"},{"key":"e_1_2_10_9_1","doi-asserted-by":"publisher","DOI":"10.1002\/cbdv.202501743"},{"key":"e_1_2_10_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.molliq.2024.125501"},{"key":"e_1_2_10_11_1","doi-asserted-by":"publisher","DOI":"10.1111\/cbdd.70155"},{"key":"e_1_2_10_12_1","doi-asserted-by":"publisher","DOI":"10.1021\/acsmedchemlett.3c00187"},{"key":"e_1_2_10_13_1","doi-asserted-by":"publisher","DOI":"10.1021\/jm200712h"},{"key":"e_1_2_10_14_1","doi-asserted-by":"publisher","DOI":"10.25259\/AJC_80_2025"},{"key":"e_1_2_10_15_1","doi-asserted-by":"publisher","DOI":"10.2174\/0929867330666221128142730"},{"key":"e_1_2_10_16_1","doi-asserted-by":"publisher","DOI":"10.2174\/0929867329666220722143547"},{"key":"e_1_2_10_17_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms24119450"},{"key":"e_1_2_10_18_1","doi-asserted-by":"publisher","DOI":"10.1002\/cmdc.201900583"},{"key":"e_1_2_10_19_1","doi-asserted-by":"publisher","DOI":"10.1080\/00397911.2017.1333124"},{"issue":"11","key":"e_1_2_10_20_1","first-page":"10","article-title":"Crystal Structures of Full\u2010Length Lanosterol 14\u03b1\u2010Demethylases of Prominent Fungal Pathogens Candida albicans and Candida Glabrata Provide Tools for Antifungal Discovery","volume":"62","author":"Keniya M. 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