{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T05:58:51Z","timestamp":1790834331197,"version":"4.1.0"},"reference-count":29,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T00:00:00Z","timestamp":1790726400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T00:00:00Z","timestamp":1790726400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Chem Biol Drug Des"],"published-print":{"date-parts":[[2026,10]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>Gastric cancer (GC) remains a highly aggressive malignancy with poor prognosis. Anoikis resistance is closely associated with tumor progression and metastasis, but the prognostic and functional relevance of anoikis\u2010related genes (ARGs) in GC remains incompletely understood. Public transcriptomic, clinical, somatic mutation, and single\u2010cell RNA sequencing (scRNA\u2010seq) datasets were integrated to identify differentially expressed ARGs, develop an ARG\u2010based risk model, and investigate its associations with tumor microenvironment (TME) features. In\u00a0vitro experiments were performed to assess the effects of selected candidate genes on GC cell migration and invasion. Forty\u2010five differentially expressed ARGs were identified in The Cancer Genome Atlas Stomach Adenocarcinoma (TCGA\u2010STAD) cohort. An ARG\u2010based risk model was developed using the TCGA\u2010STAD cohort and evaluated in the GSE84437 cohort. The model was associated with overall survival and provided potential value for risk stratification, although its discriminative performance was modest. High\u2010risk patients showed distinct immune, stromal, and somatic mutational features. Single\u2010cell analysis suggested that ARG\u2010related transcriptional programs were associated with stromal remodeling and endothelial\u2010to\u2010mesenchymal transition (EndMT)\u2010associated features in the GC microenvironment. Among the core ARGs, EEF1A2 and TAGLN showed prognostic relevance and higher protein expression in GC tissues. Small interfering RNA (siRNA)\u2010mediated knockdown of either gene reduced the migration and invasion of HGC\u201027 cells. These findings indicate that ARG\u2010related molecular features are associated with GC prognosis and immune\u2010stromal characteristics, while EEF1A2 and TAGLN may represent candidate genes related to GC cell migration and invasion.<\/jats:p>","DOI":"10.1111\/cbdd.70411","type":"journal-article","created":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T05:20:19Z","timestamp":1790832019000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["An Anoikis\u2010Related Gene Signature Associated With Stromal Remodeling and Clinical Outcome in Gastric Cancer"],"prefix":"10.1111","volume":"108","author":[{"given":"Zhijun","family":"Fu","sequence":"first","affiliation":[{"name":"Department of General Surgery Wusheng County People's Hospital (Wusheng Hospital Affiliated Hospital of North Sichuan Medical College)  Guang'an Sichuan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lin","family":"Sun","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology Chongqing Southeast Hospital  Chongqing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xing","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Oncology People's Hospital of Yilong County  Nanchong Sichuan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Biao","family":"Cheng","sequence":"additional","affiliation":[{"name":"Department of Oncology, Xinqiao Hospital Army Medical University  Chongqing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ying","family":"Huang","sequence":"additional","affiliation":[{"name":"Department of Oncology, Xinqiao Hospital Army Medical University  Chongqing 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