{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,6,8]],"date-time":"2025-06-08T18:22:46Z","timestamp":1749406966098},"reference-count":25,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2016,2,2]],"date-time":"2016-02-02T00:00:00Z","timestamp":1454371200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Child"],"published-print":{"date-parts":[[2016,5]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>HIV is known to cause neurodevelopmental problems in infants and young children. The impact of HIV on the development of preschool\u2010age children has been less well described.<\/jats:p><\/jats:sec><jats:sec><jats:title>Method<\/jats:title><jats:p>The study was conducted at an urban paediatric HIV clinic in Johannesburg, South Africa. A sample of convenience was used. Sixty\u2010eight medically stable children between the ages of 3 and 5\u2009years were assessed with the Griffiths Scales of Mental Development. Children were excluded from the study if they had severe HIV encephalopathy, which made it impossible for them to participate in the items on the Griffiths Scales of Mental Development.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The children had started combination antiretroviral treatment (cART) at a mean age of 8.1\u2009months. The majority of the children were virologically suppressed and did not present with wasting or stunting. Severe overall developmental delay (<jats:italic>z<\/jats:italic>\u2010scores\u2009&lt;\u2009\u22122SD) was detected in 55.88% of children. Developmental facets related to speech, cognition and perception were the most severely affected. Personal\u2013social development was the least affected with only 13.4% of the children demonstrating severe delay.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Despite having early access to cART, children infected with HIV are still at risk for severe developmental delay across a number of facets. Very early initiation of cART may help alleviate this problem. All preschool children infected with HIV should have routine developmental screening.<\/jats:p><\/jats:sec>","DOI":"10.1111\/cch.12321","type":"journal-article","created":{"date-parts":[[2016,2,2]],"date-time":"2016-02-02T08:13:30Z","timestamp":1454400810000},"page":"410-414","source":"Crossref","is-referenced-by-count":17,"title":["Developmental status of preschool children receiving cART: a descriptive cohort study"],"prefix":"10.1111","volume":"42","author":[{"given":"J.","family":"Potterton","sequence":"first","affiliation":[{"name":"Department of Physiotherapy University of the Witwatersrand  Johannesburg South Africa"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"N.","family":"Hilburn","sequence":"additional","affiliation":[{"name":"Department of Physiotherapy University of the Witwatersrand  Johannesburg South Africa"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"R.","family":"Strehlau","sequence":"additional","affiliation":[{"name":"Empilweni Services and Research Unit, Rahima Moosa Mother and Child Hospital, Faculty of Health Sciences University of Witwatersrand  Johannesburg South Africa"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2016,2,2]]},"reference":[{"key":"e_1_2_5_2_1","doi-asserted-by":"publisher","DOI":"10.1097\/NPT.0b013e3181846232"},{"key":"e_1_2_5_3_1","first-page":"49","article-title":"Neuropsychological evaluation of neurologically asymptomatic HIV\u2010infected children","volume":"43","author":"Bissiachi P.","year":"2000","journal-title":"Brain and Cognition"},{"key":"e_1_2_5_4_1","doi-asserted-by":"publisher","DOI":"10.2147\/HIV.S43260"},{"key":"e_1_2_5_5_1","first-page":"44","article-title":"Level of maternal education and performance of Black, South African infants on the 1996 Griffiths mental development scales","volume":"11","author":"Cockroft K.","year":"2008","journal-title":"African Journal of Psychiatry"},{"key":"e_1_2_5_6_1","unstructured":"Coovadia A. 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