{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,29]],"date-time":"2026-04-29T12:37:10Z","timestamp":1777466230097,"version":"3.51.4"},"reference-count":27,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2020,11,20]],"date-time":"2020-11-20T00:00:00Z","timestamp":1605830400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100009633","name":"Eunice Kennedy Shriver National Institute of Child Health and Human Development","doi-asserted-by":"publisher","award":["U01HD080441"],"award-info":[{"award-number":["U01HD080441"]}],"id":[{"id":"10.13039\/100009633","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Child"],"published-print":{"date-parts":[[2021,3]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Neurodevelopmental stimulation programmes can improve developmental outcomes. Antiretroviral therapy (ART) started soon after birth potentially limits the invasion of HIV into the central nervous system. A combination of developmental stimulation and early ART initiation may reduce developmental delays in children with perinatally acquired HIV infection.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>At a single site in Johannesburg, South Africa, we enrolled 36 HIV\u2010infected neonates on ART into an intervention group (IG) participating in a yearlong home\u2010based, neurodevelopmental stimulation programme. Bayley Scales of Infant and Toddler Development\u20103rd Edition (BSID\u2010III) assessments were conducted at 12 months. Scores were compared with 24 early treated HIV\u2010infected infants in an observational group (OG). BSID\u2010III assessments were also conducted for older children in an OG at 24 or 36 months. Cognitive, language and motor scaled and composite scores were analysed.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>BSID\u2010III scaled and composite scores were all higher in the IG apart from the gross motor scaled score (9.25 vs. 10, <jats:italic>p<\/jats:italic> = 0.1954). Receptive communication scaled score was significantly higher in the IG (10.96 vs. 9, <jats:italic>p<\/jats:italic> = 0.0331). IG composite scores were all higher than OG scores. OG children assessed at 24 or 36 months had lower composite scores in all subscales than 12\u2010month OG scores.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Early treated HIV\u2010infected children participating in a neurodevelopmental stimulation programme achieved higher BSID\u2010III scores at 12 months compared with early treated HIV\u2010infected children who did not receive the programme.<\/jats:p><\/jats:sec>","DOI":"10.1111\/cch.12828","type":"journal-article","created":{"date-parts":[[2020,11,5]],"date-time":"2020-11-05T13:07:20Z","timestamp":1604581640000},"page":"154-162","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Neurodevelopment in early treated HIV\u2010infected infants participating in a developmental stimulation programme compared with controls"],"prefix":"10.1111","volume":"47","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9113-6584","authenticated-orcid":false,"given":"Renate","family":"Strehlau","sequence":"first","affiliation":[{"name":"Empilweni Services and Research Unit, Rahima Moosa Mother and Child Hospital, Department of Paediatrics and Child Health, Faculty of Health Sciences University of the Witwatersrand  Johannesburg South Africa"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Megan","family":"Burke","sequence":"additional","affiliation":[{"name":"Empilweni Services and Research Unit, Rahima Moosa Mother and Child Hospital, Department of Paediatrics and Child Health, Faculty of Health Sciences University of the Witwatersrand  Johannesburg South Africa"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tamryn","family":"van Aswegen","sequence":"additional","affiliation":[{"name":"Empilweni Services and Research Unit, Rahima Moosa Mother and Child Hospital, Department of Paediatrics and Child Health, Faculty of Health Sciences University of the Witwatersrand  Johannesburg South Africa"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Louise","family":"Kuhn","sequence":"additional","affiliation":[{"name":"Gertrude H. Sergievsky Center, Vagelos College of Physicians and Surgeons Columbia University Irving Medical Center  New York City New York USA"},{"name":"Department of Epidemiology, Mailman School of Public Health Columbia University Irving Medical Center  New York City New York USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Joanne","family":"Potterton","sequence":"additional","affiliation":[{"name":"School of Therapeutic Sciences, Faculty of Health Sciences University of the Witwatersrand  Johannesburg South Africa"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2020,11,20]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"crossref","unstructured":"Bayley N.(2006).Bayley scales of infant and toddler development\u2014Technical manual third edition. 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Available fromhttp:\/\/siteresources.worldbank.org\/EXTAFRREGTOPEDUCATION\/Resources\/444707-1291071725351\/ECCD-factsheet-final.pdf(last accessed on 28 April 2017)."},{"key":"e_1_2_10_26_1","doi-asserted-by":"publisher","DOI":"10.1097\/QAI.0b013e3181b32646"},{"key":"e_1_2_10_27_1","doi-asserted-by":"publisher","DOI":"10.1097\/MD.0000000000006867"},{"key":"e_1_2_10_28_1","volume-title":"Nutrition Landscape Information System (NLIS) country profile indicators: Interpretation guide","author":"World Health Organization","year":"2010"}],"container-title":["Child: Care, Health and Development"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/cch.12828","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/cch.12828","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/cch.12828","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,2]],"date-time":"2023-09-02T04:47:48Z","timestamp":1693630068000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/cch.12828"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,11,20]]},"references-count":27,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2021,3]]}},"alternative-id":["10.1111\/cch.12828"],"URL":"https:\/\/doi.org\/10.1111\/cch.12828","archive":["Portico"],"relation":{},"ISSN":["0305-1862","1365-2214"],"issn-type":[{"value":"0305-1862","type":"print"},{"value":"1365-2214","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,11,20]]},"assertion":[{"value":"2020-05-04","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2020-11-03","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2020-11-20","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}