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This study examined the impacts of comorbidities on quality of life (QOL) of children with intellectual disabilities and whether impacts varied with caregiver perceptions that medical needs had been met.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Primary caregivers of 447 children (aged 5\u201319\u2009years) with an intellectual disability reported on their child's medical comorbidities and the extent to which they perceived their child's medical needs had been met in a cross\u2010sectional observational study. The Quality of Life Inventory\u2010Disability was used to measure QOL on a 100\u2010point scale. Linear regression models including interaction terms were used to evaluate their associations.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Parent\u2010reported recurrent child pain (\u22124.97, 95% CI \u22128.21, \u22121.72), night\u2010time sleep disturbances (\u22124.98, 95% CI \u22127.23, \u22122.73), daytime somnolence (\u22128.71, 95% CI \u221211.30, \u22122.73), seizures that occurred at least weekly (\u22127.59, 95% CI \u221213.50, \u22121.68) and conservatively managed severe scoliosis (\u22127.39, 95% CI \u221212.97, \u22121.81) were negatively associated with child QOL. Despite the majority of parents (~70%) perceiving that their child's medical needs had been met to a great extent, this did not significantly moderate the association between any comorbidities and QOL.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Comorbidities were common and had marked associations with QOL. Evaluation and management of pain and sleep disturbance continue to be high priorities in improving QOL of young people with intellectual disabilities. Further research on the optimal methods of managing these comorbidities is warranted.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/cch.12873","type":"journal-article","created":{"date-parts":[[2021,4,22]],"date-time":"2021-04-22T11:44:41Z","timestamp":1619091881000},"page":"654-666","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":58,"title":["Comorbidities and quality of life in children with intellectual disability"],"prefix":"10.1111","volume":"47","author":[{"given":"Dinah","family":"Reddihough","sequence":"first","affiliation":[{"name":"Neurodisability and Rehabilitation Murdoch Children's Research Institute  Melbourne Victoria Australia"},{"name":"Department of Paediatrics University of Melbourne  Melbourne Victoria Australia"},{"name":"Neurodevelopment and Disability Royal Children's Hospital  Parkville Victoria 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