{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,9]],"date-time":"2025-12-09T15:48:10Z","timestamp":1765295290636,"version":"3.40.5"},"reference-count":18,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2022,3,16]],"date-time":"2022-03-16T00:00:00Z","timestamp":1647388800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Child"],"published-print":{"date-parts":[[2022,9]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Patent ductus arteriosus (PDA) has been associated with early morbidities and long\u2010term developmental problems in very preterm infants.<\/jats:p><\/jats:sec><jats:sec><jats:title>Aims<\/jats:title><jats:p>The aim of this study is to investigate the effect of patent ductus arteriosus and medical treatment on long\u2010term developmental outcomes in very low birth weight infants.<\/jats:p><\/jats:sec><jats:sec><jats:title>Study design<\/jats:title><jats:p>This is a retrospective case control observational study.<\/jats:p><\/jats:sec><jats:sec><jats:title>Subject<\/jats:title><jats:p>The study included preterm infants who were born before 30\u2009weeks' gestation and birth weight less than 1,500\u2009g and underwent neurodevelopmental testing at a corrected age of 24\u2009months during follow\u2010up in our centre. The results of neurodevelopmental assessment using the Bayley Scales of Infant Development II at 24\u2009months of corrected age and other morbidities were recorded.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Of 820 infants screened, the 2\u2010year data of 647 infants (78%) were analysed. The mean gestational age was 27.4\u00a0weeks (\u00b11.7\u00a0weeks), mean birth weight was 980\u2009g (\u00b1250\u2009g) and 283 (44%) of the infants received pharmaceutical treatment for hemodynamically significant PDA. The prevalence of neurodevelopmental impairment was higher in infants with PDA compared to those without PDA (odds ratio [OR], 1.6; 95% CI, 1.13\u20132.29; chi\u2010square, Fisher's exact test <jats:italic>P<\/jats:italic>\u2009=\u2009.009). However, when birth weight and gestational age were corrected for as covariates and other risk factors were added to the analysis, PDA alone was not an independent risk factor for neurodevelopmental problems (OR, 1.12; 95% CI, 0.824\u20131.549; <jats:italic>P<\/jats:italic>\u2009=\u2009.450). There was no difference between the groups who received ibuprofen or paracetamol for PDA.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Although we have not found an association between hemodynamically significant PDA and poor neurodevelopment, this potentially needs to be investigated.<\/jats:p><\/jats:sec>","DOI":"10.1111\/cch.12997","type":"journal-article","created":{"date-parts":[[2022,3,11]],"date-time":"2022-03-11T08:41:29Z","timestamp":1646988089000},"page":"862-868","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Long\u2010term neurodevelopmental outcomes in very low birth weight infants with and without patent ductus arteriosus: A retrospective case control observational study"],"prefix":"10.1111","volume":"48","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2113-5591","authenticated-orcid":false,"given":"Sarkhan","family":"Elbayiyev","sequence":"first","affiliation":[{"name":"University of Health Sciences, Ankara City Hospital Department of Neonatology  Ankara Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9307-3003","authenticated-orcid":false,"given":"Fuat Emre","family":"Canpolat","sequence":"additional","affiliation":[{"name":"University of Health Sciences, Ankara City Hospital Department of Neonatology  Ankara Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4831-8950","authenticated-orcid":false,"given":"G\u00fcls\u00fcm","family":"Kad\u0131o\u011flu \u015eim\u015fek","sequence":"additional","affiliation":[{"name":"University of Health Sciences, Ankara City Hospital Department of Neonatology  Ankara Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2999-059X","authenticated-orcid":false,"given":"Sehribanu","family":"I\u015f\u0131k","sequence":"additional","affiliation":[{"name":"University of Health Sciences, Ankara City Hospital Department of Neonatology  Ankara Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8937-4671","authenticated-orcid":false,"given":"Mehmet","family":"B\u00fcy\u00fcktiryaki","sequence":"additional","affiliation":[{"name":"University of Health Sciences, Ankara City Hospital Department of Neonatology  Ankara Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3177-9411","authenticated-orcid":false,"given":"Hayriye G\u00f6zde","family":"Kanmaz Kutman","sequence":"additional","affiliation":[{"name":"University of Health Sciences, Ankara City Hospital Department of Neonatology  Ankara Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2022,3,16]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1159\/000500269"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1097\/00000658-197801000-00001"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpeds.2018.08.004"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpeds.2020.10.024"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1002\/14651858.CD013133.pub2"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1542\/peds.2020-1209"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.earlhumdev.2020.105042"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.1001\/archopht.123.7.991"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpeds.2015.06.054"},{"key":"e_1_2_9_11_1","doi-asserted-by":"publisher","DOI":"10.1542\/peds.2015-3090"},{"key":"e_1_2_9_12_1","doi-asserted-by":"publisher","DOI":"10.1542\/peds.2007-0925"},{"key":"e_1_2_9_13_1","doi-asserted-by":"publisher","DOI":"10.1542\/peds.2008-2418"},{"key":"e_1_2_9_14_1","doi-asserted-by":"publisher","DOI":"10.1055\/s-0037-1601564"},{"key":"e_1_2_9_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpeds.2013.11.008"},{"key":"e_1_2_9_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-3476(78)80282-0"},{"key":"e_1_2_9_17_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41372-020-00772-2"},{"key":"e_1_2_9_18_1","doi-asserted-by":"publisher","DOI":"10.1159\/000506988"},{"key":"e_1_2_9_19_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamapediatrics.2016.5143"}],"container-title":["Child: 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