{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,18]],"date-time":"2026-10-18T02:27:27Z","timestamp":1792290447944,"version":"4.4.0"},"reference-count":66,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2023,10,16]],"date-time":"2023-10-16T00:00:00Z","timestamp":1697414400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Child"],"published-print":{"date-parts":[[2024,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Accumulation of bilirubin above normal levels is considered a neurological risk factor for both premature and full\u2010term newborns. This systematic review aimed to determine the effect of neonatal hyperbilirubinemia on neurodevelopment in preterm and full\u2010term newborns.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>PubMed, EMBASE, Cochrane Library, CINAHL, PsycINFO, Scopus and Lilacs databases were searched for articles published until 1 June 2022. The quality of cohort and case\u2013control studies was assessed with the Newcastle\u2013Ottawa Scale, and the MINCir scale was used to evaluate the methodological quality of therapy studies or the therapeutic procedures. Premature neonates without neurological conditions and those born at term with hyperbilirubinemia as the sole risk factor were included. Studies reporting one or more neurodevelopmental outcomes were included with an inter\u2010group comparison of a hyperbilirubinemia group versus a non\u2010hyperbilirubinemia or non\u2010pathological hyperbilirubinemia group. The main outcomes were auditory function, visual function, cognitive function, motor function, behavior, global development and neurological risk.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The search identified 951 studies, 19 of which (<jats:italic>n<\/jats:italic>\u2009=\u20092210 newborns) were finally included. Fifteen of the cohort and case\u2013control studies presented low risk of bias, and six studies showed high methodological quality. Within the preterm population, hyperbilirubinemia as the sole risk factor was not shown to affect neurodevelopment. Auditory, neurological and motor development alterations were found in the population of full\u2010term newborns with hyperbilirubinemia, which were more evident during the first year of life.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Elevated bilirubin levels may be a trigger for the onset of neurodevelopmental disorders in full\u2010term infants during the first year of life. More studies are warranted in the preterm population with hyperbilirubinemia to draw conclusions about its impact on their neurodevelopment.<\/jats:p><\/jats:sec>","DOI":"10.1111\/cch.13183","type":"journal-article","created":{"date-parts":[[2023,10,16]],"date-time":"2023-10-16T10:24:00Z","timestamp":1697451840000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":22,"title":["Neonatal hyperbilirubinemia and repercussions on neurodevelopment: A systematic review"],"prefix":"10.1111","volume":"50","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7647-0258","authenticated-orcid":false,"given":"Javier","family":"Merino\u2010Andr\u00e9s","sequence":"first","affiliation":[{"name":"Faculty of Physiotherapy and Nursing, Physiotherapy Research Group of Toledo (GITFO) Universidad de Castilla\u2010La Mancha  Toledo Spain"},{"name":"Physiotherapy Research Group of Toledo (GIFTO) Universidad de Castilla\u2010La Mancha  Toledo Spain"},{"name":"Centro Crecer  Toledo Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Soraya","family":"P\u00e9rez\u2010Nombela","sequence":"additional","affiliation":[{"name":"Faculty of Physiotherapy and Nursing, Physiotherapy Research Group of Toledo (GITFO) Universidad de Castilla\u2010La Mancha  Toledo Spain"},{"name":"Physiotherapy Research Group of Toledo (GIFTO) Universidad de Castilla\u2010La Mancha  Toledo Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Celia","family":"\u00c1lvarez\u2010Bueno","sequence":"additional","affiliation":[{"name":"Social and Health Care Research Center Universidad de Castilla\u2010La Mancha  Cuenca Spain"},{"name":"Universidad Polit\u00e9cnica y Art\u00edstica del Paraguay  Asunci\u00f3n Paraguay"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6294-7476","authenticated-orcid":false,"given":"\u00c1lvaro","family":"Hidalgo\u2010Robles","sequence":"additional","affiliation":[{"name":"Physiotherapy Research Group of Toledo (GIFTO) Universidad de Castilla\u2010La Mancha  Toledo Spain"},{"name":"Universidad Internacional de La Rioja  La Rioja Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Irene","family":"Ruiz\u2010Becerro","sequence":"additional","affiliation":[{"name":"Integrandes  Madrid Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Francisco Javier","family":"Fern\u00e1ndez\u2010Rego","sequence":"additional","affiliation":[{"name":"Physiotherapy Department University of Murcia  Murcia Spain"},{"name":"Early Care Research Group (GIAT) University of Murcia  Murcia Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2023,10,16]]},"reference":[{"issue":"6","key":"e_1_2_11_2_1","first-page":"513","article-title":"Brainstem auditory evoked response in newborns with hyperbilirubinemia","volume":"35","author":"Agrawal V. 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