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biological pathways, indexed by DNA methylation, between ODD trajectories and attention deficit hyperactivity disorder (ADHD); (c) genetic influence on DNA methylation; and (d) prenatal risk exposure associations. Methylome-wide significant associations were identified for the ODD and headstrong, but not for irritable. Overlap analysis indicated biological correlates between ODD, headstrong, and ADHD. DNA methylation in ODD and headstrong was (to a degree) genetically influenced. DNA methylation associated with prenatal risk exposures of maternal anxiety (headstrong) and cigarette smoking (ODD and headstrong).<\/jats:p>","DOI":"10.1111\/cdev.12957","type":"journal-article","created":{"date-parts":[[2017,9,20]],"date-time":"2017-09-20T02:28:41Z","timestamp":1505874521000},"page":"1839-1855","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":19,"title":["A Methylome-Wide Association Study of Trajectories of Oppositional Defiant Behaviors and Biological Overlap With Attention Deficit Hyperactivity Disorder"],"prefix":"10.1093","volume":"89","author":[{"given":"Edward D","family":"Barker","sequence":"first","affiliation":[{"name":"King's College London"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Esther","family":"Walton","sequence":"additional","affiliation":[{"name":"University of Bristol"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Charlotte A 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