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Analyses included 676 mother-child dyads, 393 of whom completed an observational caregiver sensitivity measure. Participants were primarily ethnic minorities (42.7% Black, 25.4% Hispanic); 22.1% of children had \u2265 1 wheezing episode. Higher adversity was associated with increased wheeze frequency and blunted diurnal cortisol slope. The indirect effect of adversity on wheezing through cortisol slope was significant for females, but not males. Higher caregiver sensitivity was protective against wheezing for males, but not females, with high cortisol. Findings suggest complex associations among adversity, cortisol, child sex, and caregiver sensitivity in predicting wheezing.<\/jats:p>","DOI":"10.1111\/cdev.13606","type":"journal-article","created":{"date-parts":[[2021,6,15]],"date-time":"2021-06-15T04:31:14Z","timestamp":1623731474000},"page":"e1260-e1274","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["Early Adverse Experiences and Repeated Wheezing From 6 to 30 Months of Age: Investigating the Roles of Hypothalamic\u2013Pituitary\u2013Adrenal Axis Functioning, Child Sex, and Caregiving Sensitivity"],"prefix":"10.1093","volume":"92","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4636-7687","authenticated-orcid":false,"given":"Allison","family":"Frost","sequence":"first","affiliation":[{"name":"University of North Carolina Chapel Hill"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michelle 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