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In Latin America, data on HCN are limited by the scarcity of population\u2010based cancer registries.<\/jats:p><\/jats:sec><jats:sec><jats:title>Objective<\/jats:title><jats:p>To describe survival and changes in the time trends of incidence and mortality rates of HCN with data from the Cali Cancer Population Registry (Colombia) during 1962\u20102018.<\/jats:p><\/jats:sec><jats:sec><jats:title>Method<\/jats:title><jats:p>Males and females of any age residing in Cali were included. The trends in incidence rates (1962\u20102016) and mortality (1984\u20102018) were analysed by calculating the mean annual percentage change (APC). Five\u2010year net survival was estimated for the four 5\u2010year periods of 1996\u20102015 using the Pohar\u2010Perme method.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>During 1962\u20102015, 5,110 new cases of HNC were recorded: 1,506 in the larynx, 1,377 in the oral cavity, 487 in the nose and paranasal sinuses, 643 in the oropharynx, 603 in the salivary glands and 360 in Naso\u2010Hypopharynx region. The incidence rates of HNC decreased significantly at all subsites, except in those associated with the human papillomavirus. Between 1984 and 2018, there were 1,941 deaths attributed to HNC, and the mortality rate decreased significantly. The 5\u2010year age\u2010standardized net survival was 43.2% in 1996\u20102000, remained stable during the following decade, and for 2011\u20102015 it was 50.9%.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>The incidence and mortality of HNC in Cali decreased significantly during the study period in both sexes.<\/jats:p><\/jats:sec>","DOI":"10.1111\/cdoe.12671","type":"journal-article","created":{"date-parts":[[2021,6,9]],"date-time":"2021-06-09T13:01:40Z","timestamp":1623243700000},"page":"292-299","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":11,"title":["Head and neck cancer in Cali, Colombia: Population\u2010based study"],"prefix":"10.1111","volume":"50","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4261-306X","authenticated-orcid":false,"given":"Natalia","family":"Arag\u00f3n","sequence":"first","affiliation":[{"name":"School of Dentistry Universidad del Valle Cali 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