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Studies that assessed the efficiency of PT versus no treatment or other dental treatments were included. Risk of bias was assessed using the Cochrane RoB 2, ROBINS\u2010I and ECOBIAS tools for the first stage of EE and the CHEERS checklist and NICE quality appraisal tool for overall EE. Qualitative and quantitative syntheses of the articles were conducted and assessed using the GRADE approach.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Eleven studies were included. PT reduces total healthcare costs, including inpatient and outpatient, diabetes\u2010related costs and other drug costs (low to moderate certainty). A total incremental net benefit of USD 12 348 (2022 currency, 95% CI 12 195\u201312 500) was estimated from three high\u2010quality model\u2010based cost\u2010utility analyses (high certainty).<\/jats:p><\/jats:sec><jats:sec><jats:title>Discussion<\/jats:title><jats:p>The inclusion of PT in the comprehensive treatment of patients with T2DM and periodontitis is cost\u2010effective. Future research is required to ensure the transferability of these findings and inform decision makers from different countries.<\/jats:p><\/jats:sec><jats:sec><jats:title>Registration<\/jats:title><jats:p>PROSPERO CRD42023443146.<\/jats:p><\/jats:sec>","DOI":"10.1111\/cdoe.12999","type":"journal-article","created":{"date-parts":[[2024,8,16]],"date-time":"2024-08-16T11:19:45Z","timestamp":1723807185000},"page":"135-151","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":9,"title":["Efficiency of periodontal treatment to improve type 2 diabetes mellitus outcomes: A systematic review and meta\u2010analysis of economic evaluations"],"prefix":"10.1111","volume":"53","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8959-3989","authenticated-orcid":false,"given":"Gustavo","family":"S\u00e1enz\u2010Ravello","sequence":"first","affiliation":[{"name":"Center for Surveillance and Epidemiology of Oral Diseases, Faculty of Dentistry 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