{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,23]],"date-time":"2026-08-23T16:04:39Z","timestamp":1787501079345,"version":"build-2736575974"},"reference-count":25,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2024,8,19]],"date-time":"2024-08-19T00:00:00Z","timestamp":1724025600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Comm Dent Oral Epid"],"published-print":{"date-parts":[[2025,2]]},"abstract":"Abstract<\/jats:title>\n \n Objective<\/jats:title>\n Dental caries is one of the most prevalent chronic non\u2010communicable diseases worldwide. There is a lack of evidence, especially in adult populations, documenting caries disease progression considering lesion severity, activity and tooth surface\u2010level characteristics. The study aimed to investigate the extent to which primary active caries lesions in adults affect caries lesions progression compared with inactive caries lesions over a 2\u2010year follow\u2010up period, considering their severity, surface and tooth type.<\/jats:p>\n <\/jats:sec>\n \n Methods<\/jats:title>\n A prospective study data set from a cohort of workers in a factory in Belarus were used. Participants aged 18\u201364\u2009years with 20 or more natural teeth were included in the study. The participants were clinically examined twice within an interval of 2\u2009years and completed a self\u2010reported questionnaire. One calibrated examiner evaluated caries lesions using the International Caries Detection and Assessment System (ICDAS) and the Nyvad system. The primary outcome was caries lesions' progression. The lesion was classified as \u2018progressed\u2019 if it turned to a more advanced severity stage, was restored or missing\/extracted due to caries. A multilevel Poisson regression was used to estimate the association between baseline caries lesions' characteristics and caries lesion progression.<\/jats:p>\n <\/jats:sec>\n \n Results<\/jats:title>\n \n Out of 495 participants, 322 people completed clinical examinations at baseline and 2\u2009years later, with an attrition rate of 35%. The prevalence of active DS1\u20106 and DS5\u20106 lesions at the baseline was 83.8% and 64.8%, respectively. In 2\u2009years, 24% of active non\u2010cavitated and 31% of active micro\u2010cavitated\/shadowed caries lesions progressed, while 15% of inactive caries lesions, non\u2010 or micro\u2010cavitated\/shadowed, progressed. The adjusted rate ratio (RR) for ICDAS\n 3\u2009+\u20094<\/jats:sub>\n caries lesions progression was 1.41 (CI 95% 1.16, 1.70) than ICDAS\n 1\u2009+\u20092<\/jats:sub>\n lesions. The RR for ICDAS\n 1\u2009+\u20092<\/jats:sub>\n , active and ICDAS\n 3\u2009+\u20094<\/jats:sub>\n , active lesions was 1.78 (CI 95%, 1.40, 2.27) and 1.97 (CI 95%, 1.53, 2.55), respectively than ICDAS\n 1\u2009+\u20092<\/jats:sub>\n , inactive lesions. The RR for caries lesions progression on proximal surfaces and on pits and fissures was 1.57 (CI 95%, 1.30, 1.89) and 1.37 (CI 95%, 1.11, 1.67), respectively than smooth surface lesions.\n <\/jats:p>\n <\/jats:sec>\n \n Conclusion<\/jats:title>\n In caries active adults over 2\u2009years, most non\u2010 and micro\u2010cavitated\/shadowed active and inactive caries lesions did not progress. Among caries lesions that showed progression, more severe lesions were more likely to progress than less severe lesions; active lesions were more likely to progress than inactive lesions. Pit and fissure caries lesions and proximal lesions were more likely to progress than smooth surface lesions.<\/jats:p>\n <\/jats:sec>","DOI":"10.1111\/cdoe.13005","type":"journal-article","created":{"date-parts":[[2024,8,20]],"date-time":"2024-08-20T00:29:21Z","timestamp":1724113761000},"page":"33-41","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["Caries lesions progression in adults: A prospective 2\u2010year cohort study"],"prefix":"10.1111","volume":"53","author":[{"given":"Hoda","family":"Abdalla","sequence":"first","affiliation":[{"name":"Faculty of Dental Medicine and Oral Health Sciences McGill University Montreal Quebec Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paul J.","family":"Allison","sequence":"additional","affiliation":[{"name":"Faculty of Dental Medicine and Oral Health Sciences McGill University Montreal Quebec Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9406-6518","authenticated-orcid":false,"given":"Sreenath A.","family":"Madathil","sequence":"additional","affiliation":[{"name":"Faculty of Dental Medicine and Oral Health Sciences McGill University Montreal Quebec Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jacques E.","family":"Veronneau","sequence":"additional","affiliation":[{"name":"Faculty of Dental Medicine and Oral Health Sciences McGill University Montreal Quebec Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Natallia","family":"Pustavoitava","sequence":"additional","affiliation":[{"name":"Department of Operative Dentistry Belarusian State Medical University Minsk Belarus"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3559-8538","authenticated-orcid":false,"given":"Svetlana","family":"Tikhonova","sequence":"additional","affiliation":[{"name":"Faculty of Dental Medicine and Oral Health Sciences McGill University Montreal Quebec Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2024,8,19]]},"reference":[{"key":"e_1_2_12_2_1","doi-asserted-by":"publisher","DOI":"10.1177\/0022034514531017"},{"issue":"01","key":"e_1_2_12_3_1","doi-asserted-by":"crossref","DOI":"10.1590\/1807-3107bor-2021.vol35.0055","article-title":"Management of dental caries lesions in Latin American and Caribbean countries","volume":"35","author":"Pozos\u2010Guill\u00e9n A","year":"2021","journal-title":"Braz Oral 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