{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T00:46:31Z","timestamp":1787013991692,"version":"build-2736575974"},"reference-count":91,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2024,10,22]],"date-time":"2024-10-22T00:00:00Z","timestamp":1729555200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001691","name":"Japan Society for the Promotion of Science","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001691","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Comm Dent Oral Epid"],"published-print":{"date-parts":[[2025,8]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>To systematically assess current evidence on the extent to which social relationships are associated with tooth loss in adults aged 60\u2009years and older.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>A systematic literature search was conducted on PubMed, Embase, Web of Science, CINAHL and The Cochrane Library databases to identify relevant studies published from 1966 up to March 2024. Cross\u2010sectional or cohort studies investigating the association between structural, functional and\/or combined (structural and functional) components of social relationships and the number of remaining teeth or edentulism among community\u2010dwelling or institutionalised older adults were included. Data were extracted on participants' and study characteristics, including study design, the type of measures used to assess social relationships (structural, functional, and combined), outcome measures and association estimates. The quality of the studies was assessed using the Newcastle\u2010Ottawa Scale (NOS) for cohort studies and the adapted NOS for cross\u2010sectional studies. The reported association between social relationships and the number of remaining teeth or edentulism was summarised using meta\u2010analysis with robust variance estimation.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Twenty studies were included in the review and 12 studies (125\u2009553 participants) in the meta\u2010analysis. Across the 12 studies, the average odds ratio (95% confidence interval) was 1.15 (1.01\u20131.32), indicating a 15% higher likelihood of having a lower number of teeth or edentulism for those with weaker social relationships. The GRADE certainty of the body of evidence was low.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Weak social relationships were associated with a lower number of teeth or edentulism in older adults. Our findings may inform potential public health approaches that target and modify social relationships to prevent and address older adults' oral diseases. Still, the directionality and the underlying mechanisms connecting social relationships and tooth loss need to be further explored by longitudinal studies with follow\u2010up long enough for oral health outcomes or changes in social relationships to occur.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Trial Registration<\/jats:title>\n                    <jats:p>Protocol Registration: PROSPERO (CRD42023417845)<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/cdoe.13011","type":"journal-article","created":{"date-parts":[[2024,10,22]],"date-time":"2024-10-22T08:39:20Z","timestamp":1729586360000},"page":"337-346","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["Social Relationships and Tooth Loss in Adults Aged 60\u2009Years and Older: A Systematic Review and Meta\u2010Analysis"],"prefix":"10.1111","volume":"53","author":[{"given":"Eiko","family":"Yoshida\u2010Kohno","sequence":"first","affiliation":[{"name":"Research Development Center Institute of Science Tokyo  Tokyo Japan"},{"name":"Institute of Global Health Policy Research (iGHP), Bureau of International Health Cooperation National Center for Global Health and Medicine  Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kenji","family":"Fueki","sequence":"additional","affiliation":[{"name":"Department of Masticatory Function and Health Science, Graduate School of Medical and Dental Sciences Institute of Science Tokyo  Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Amal A.","family":"Wanigatunga","sequence":"additional","affiliation":[{"name":"Department of Epidemiology Johns Hopkins Bloomberg School of Public Health  Baltimore Maryland USA"},{"name":"Center on Aging and Health Johns Hopkins University and Medical Institutions  Baltimore Maryland USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thomas K. 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