{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,12]],"date-time":"2026-06-12T10:35:36Z","timestamp":1781260536766,"version":"3.54.1"},"reference-count":31,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2025,8,19]],"date-time":"2025-08-19T00:00:00Z","timestamp":1755561600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Comm Dent Oral Epid"],"published-print":{"date-parts":[[2025,12]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Objectives<\/jats:title>\n                    <jats:p>To assess the effect of age\u2010period\u2010birth cohort on mortality rates related to lip\/oral and oropharyngeal cancer (LOOPC) in Brazil from 1980 to 2019 and to estimate the future mortality rate for 2042.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Materials and Methods<\/jats:title>\n                    <jats:p>Mortality rate per 100\u2009000 inhabitants, and age\u2010standardised mortality rate (ASR) per 100\u2009000 inhabitants were estimated. The Prais\u2010Winsten regression model was used to estimate the trends and the annual percent change (APC%). The age\u2010period\u2010cohort effects were calculated using the Poisson regression model. Lee\u2010Carter model was employed to perform projections.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      A total of 134\u2009941 deaths were observed. Prais\u2010Winsten regression model revealed a slight upward trend in lip and oral cancer mortality among men (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.04) and women (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.02), as well as in oropharyngeal cancer among men (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.02). Significant age\u2010period\u2010cohort was observed for\n                      <jats:styled-content style=\"fixed-case\">LOOPC<\/jats:styled-content>\n                      in both sexes (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.01). The risk ratio declined in recent cohorts for men (Both Cancers) but increased for women (Lip\/Oral Cancer). Period analysis showed a risk increase for lip\/oral cancer in recent periods in both sexes and a decrease for men and women for oropharyngeal cancer. In 2042, mortality projections decrease in lip\/oral cancer for men aged between 40 and 60\u2009years and oropharyngeal cancer in men between 35 and 60\u2009years. For women, no significant changes are projected. The model projections mortality rate reveal varied outcomes across the diverse regions of Brazil.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>A significant age\u2010period cohort was observed over the 40\u2009years assessed. Projections for 2042 indicated a significant decrease in LOOPC mortality rates for men and no change for women.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/cdoe.70014","type":"journal-article","created":{"date-parts":[[2025,8,20]],"date-time":"2025-08-20T03:59:01Z","timestamp":1755662341000},"page":"696-704","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Oral and Oropharyngeal Cancer Mortality in Brazil: Estimates and Projections up to 2042"],"prefix":"10.1111","volume":"53","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3695-0361","authenticated-orcid":false,"given":"Luiz Alexandre","family":"Chisini","sequence":"first","affiliation":[{"name":"Department of Restorative Dentistry, School of Dentistry Federal University of Pelotas  Pelotas Rio Grande do Sul Brazil"},{"name":"RadboudUMC  Nijmegen the Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5809-8272","authenticated-orcid":false,"given":"Luana Carla","family":"Salvi","sequence":"additional","affiliation":[{"name":"RadboudUMC  Nijmegen the Netherlands"},{"name":"Structural Genomics Laboratory, Technological Development Center Federal University of Pelotas  Pelotas Rio Grande do Sul Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Francine dos Santos","family":"Costa","sequence":"additional","affiliation":[{"name":"Federal University Pelotas  Pelotas Rio Grande do Sul Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rodrigo Varella","family":"de Carvalho","sequence":"additional","affiliation":[{"name":"Department of Dentristry Federal University of Juiz de Fora  Governador Valadares Minas Gerais Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6560-9536","authenticated-orcid":false,"given":"Ana Carolina Uchoa","family":"Vasconcelos","sequence":"additional","affiliation":[{"name":"School of Dentistry, Faculty of Pharmacy, Dentistry and Nursing, Federal University of Cear\u00e1  Fortaleza Brazil"},{"name":"Federal University of Cear\u00e1  Pelotas Rio Grande do Sul Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2025,8,19]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(22)01438-6"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1002\/ijc.31937"},{"key":"e_1_2_9_4_1","doi-asserted-by":"crossref","DOI":"10.1590\/1980-549720220034","article-title":"Trends of Incidence, Mortality, and Disability\u2010Adjusted Life Years of Oral Cancer in Latin America","volume":"25","author":"Serna B. 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