{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,9]],"date-time":"2026-09-09T05:26:22Z","timestamp":1788931582331,"version":"build-2803163510"},"reference-count":45,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2025,9,26]],"date-time":"2025-09-26T00:00:00Z","timestamp":1758844800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100008368","name":"Gigtforeningen","doi-asserted-by":"publisher","award":["R171\u2010A5894"],"award-info":[{"award-number":["R171\u2010A5894"]}],"id":[{"id":"10.13039\/100008368","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Comm Dent Oral Epid"],"published-print":{"date-parts":[[2025,12]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Objectives<\/jats:title>\n                    <jats:p>While regular periodontal care is advocated to reduce tooth loss considerably among periodontitis patients, evidence from observational studies is often limited to small single\u2010center studies. This study aims to quantify the effect of periodontal care on tooth extractions among 40\u2010year\u2010old new periodontitis patients over 20\u2009years.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>A nationwide register\u2010based cohort study was conducted, encompassing 40\u2010year\u2010old individuals with incident periodontitis in 2001, tracked through Danish registers until the end of 2021. Receiving any periodontal care was determined annually, and the number of tooth extractions served as the annually varying outcome. G\u2010estimation of structural nested mean models adjusted for time\u2010varying confounding and loss to follow\u2010up was employed to estimate the average treatment effect of periodontal therapy on subsequent tooth extractions.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>The study included 1251 40\u2010year\u2010olds with incident periodontitis in 2001. The average follow\u2010up from 2002 onwards was 19.1\u2009years and amounted to 23,878 person\u2010years. On average, participants received periodontal care in 12.1\u2009years (SD 6.3) and lost an average of 2.3 teeth (SD 3.5). G\u2010estimation showed that receiving periodontal therapy in a given year compared to not receiving any periodontal therapy reduced the number of teeth extracted in the following year by 0.04 (95% CI: 0.02; 0.06). Receiving periodontal therapy for 5\u2009years in a row compared to not receiving any periodontal therapy was associated with an average of 0.08 (95% CI: 0.04; 0.13) fewer extracted teeth, while on average 0.62 teeth were lost in a 5\u2010year period (0.12 per year).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Periodontal therapy resulted in a modest reduction in tooth extractions among 40\u2010year\u2010olds with incident periodontitis over 20\u2009years. The effectiveness of periodontal therapy against tooth loss seems to be considerably smaller than indicated by earlier clinical studies.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/cdoe.70026","type":"journal-article","created":{"date-parts":[[2025,9,27]],"date-time":"2025-09-27T06:40:18Z","timestamp":1758955218000},"page":"724-736","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["Assessing the Impact of Periodontal Therapy on Tooth Loss: A Register\u2010Based Longitudinal Study in Denmark"],"prefix":"10.1111","volume":"53","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9258-9355","authenticated-orcid":false,"given":"Eero","family":"Raittio","sequence":"first","affiliation":[{"name":"Department of Dentistry and Oral Health Aarhus University  Aarhus Denmark"},{"name":"Institute of Dentistry University of Eastern Finland  Kuopio Finland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2195-8053","authenticated-orcid":false,"given":"Vibeke","family":"Baelum","sequence":"additional","affiliation":[{"name":"Department of Dentistry and Oral Health Aarhus University  Aarhus 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