{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,1]],"date-time":"2026-08-01T09:15:55Z","timestamp":1785575755663,"version":"3.56.0"},"reference-count":40,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2012,10,29]],"date-time":"2012-10-29T00:00:00Z","timestamp":1351468800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Clin Experimental Allergy"],"published-print":{"date-parts":[[2012,11]]},"abstract":"Summary<\/jats:title>Background<\/jats:title>Specific food\u2010dependent exercise\u2010induced anaphylaxis (S<\/jats:styled-content>\u2010FDEIA<\/jats:styled-content>n) is a distinct form of food allergy in which symptoms are elicited by exercise performed after ingesting food to which the patient has become sensitised. Non\u2010specific FDEIA<\/jats:styled-content>n (NS<\/jats:styled-content>\u2010FDEIA<\/jats:styled-content>n) is a syndrome provoked by exercise performed after ingesting any food.<\/jats:p><\/jats:sec>Objective<\/jats:title>We sought to identify the culprit allergenic molecules in patients with FDEIA<\/jats:styled-content>n, combining \u2018classic\u2019 allergy testing with an allergenic molecule\u2010based microarray approach for I<\/jats:styled-content>gE<\/jats:styled-content> detection.<\/jats:p><\/jats:sec>Methods<\/jats:title>All subjects were evaluated who reported at least one episode of anaphylaxis in association with physical exercise performed within 4\u00a0h after a meal. We performed skin prick tests (SPT<\/jats:styled-content>) with commercial food extracts, prick plus prick tests (P<\/jats:styled-content>\u00a0+\u00a0P<\/jats:styled-content>) with fresh foods (P<\/jats:styled-content>\u00a0+\u00a0P<\/jats:styled-content>), and serum specific I<\/jats:styled-content>gE<\/jats:styled-content> assays by means of both the I<\/jats:styled-content>mmunoCAP<\/jats:styled-content> (CAP<\/jats:styled-content>) and the ISAC<\/jats:styled-content> 89 microarray system (ISAC<\/jats:styled-content>).<\/jats:p><\/jats:sec>Results<\/jats:title>Among our 82 FDEIA<\/jats:styled-content>n patients, the most frequent suspected foods were tomato, cereals, and peanut. SPT<\/jats:styled-content>, P<\/jats:styled-content>\u00a0<\/jats:italic>+\u00a0<\/jats:italic>P<\/jats:styled-content>, and CAP<\/jats:styled-content> displayed different degrees of sensitivity. Each test disclosed some positivities not discovered by others. Seventy\u2010nine subjects were positive to at least one food (49 to more than 20), whereas three were negative. All suspected foods were positive to at least one of SPT<\/jats:styled-content>, P<\/jats:styled-content>\u00a0<\/jats:italic>+\u00a0<\/jats:italic>P<\/jats:styled-content>, and CAP<\/jats:styled-content>. When tested using the ISAC<\/jats:styled-content>, 64 (78%) subjects were positive to P<\/jats:styled-content>ru p 3 [peach lipid transfer protein (LTP<\/jats:styled-content>)], 13 were positive to other food allergen molecules, and five displayed negative results to all food allergenic molecules. Overall, 79 patients probably had S<\/jats:styled-content>\u2010FDEIA<\/jats:styled-content>n and the other 3 NS<\/jats:styled-content>\u2010FDEIA<\/jats:styled-content>n.<\/jats:p><\/jats:sec>Conclusions<\/jats:title>Multiple food hypersensitivity represents a clinical hallmark of a large percentage of FDEIA<\/jats:styled-content>n patients. The very high prevalence of I<\/jats:styled-content>gE<\/jats:styled-content> to the LTP<\/jats:styled-content> suggests a role of this allergen group in causing S<\/jats:styled-content>\u2010FDEIA<\/jats:styled-content>n.<\/jats:p><\/jats:sec>","DOI":"10.1111\/cea.12011","type":"journal-article","created":{"date-parts":[[2012,10,29]],"date-time":"2012-10-29T16:47:36Z","timestamp":1351529256000},"page":"1643-1653","source":"Crossref","is-referenced-by-count":118,"title":["Lipid transfer proteins: the most frequent sensitizer in I<\/scp>talian subjects with food\u2010dependent exercise\u2010induced anaphylaxis"],"prefix":"10.1111","volume":"42","author":[{"given":"A.","family":"Romano","sequence":"first","affiliation":[{"name":"Allergy Unit Complesso Integrato Columbus Rome Italy"},{"name":"IRCCS Oasi Maria S.S. 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