{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,7]],"date-time":"2026-07-07T00:20:34Z","timestamp":1783383634770,"version":"3.54.6"},"reference-count":23,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2012,12,24]],"date-time":"2012-12-24T00:00:00Z","timestamp":1356307200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Clin Experimental Allergy"],"published-print":{"date-parts":[[2013,1]]},"abstract":"<jats:title>Summary<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Multiple Non\u2010steroidal anti\u2010inflammatory drugs <jats:bold>(<\/jats:bold><jats:styled-content style=\"fixed-case\">NSAID<\/jats:styled-content>)\u2010induced urticaria\/angioedema is the most common manifestation of hypersensitivity reactions to <jats:styled-content style=\"fixed-case\">NSAID<\/jats:styled-content>s. Diagnostic evaluation is based on the clinical history and a drug provocation test.<\/jats:p><\/jats:sec><jats:sec><jats:title>Objective<\/jats:title><jats:p>To evaluate the role of the clinical history in the diagnosis of multiple <jats:styled-content style=\"fixed-case\">NSAID<\/jats:styled-content>\u2010induced urticaria\/angioedema.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We studied a group of patients with an unequivocal history of urticaria and\/or angioedema after <jats:styled-content style=\"fixed-case\">NSAID<\/jats:styled-content> intake. Subjects had to have had at least two episodes of cutaneous symptoms with two different <jats:styled-content style=\"fixed-case\">COX<\/jats:styled-content>\u20101 inhibitors. The diagnosis was confirmed in all cases by a drug provocation test with acetyl salicylic acid (<jats:styled-content style=\"fixed-case\">ASA<\/jats:styled-content>). Multivariate analysis was done by analysing different variables, including number of drugs involved, episodes and time elapsed between drug intake and symptom onset.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Of the total group of 75 cases with multiple <jats:styled-content style=\"fixed-case\">NSAID<\/jats:styled-content>\u2010induced urticaria\/angioedema diagnosed according to the clinical history, 76% developed a positive drug provocation test with <jats:styled-content style=\"fixed-case\">ASA<\/jats:styled-content>. The risk for having hypersensitivity was 17 times higher in patients who developed symptoms within the first 60\u00a0min after drug intake, 13 times higher in those who experienced reactions with more than two non\u2010chemically related <jats:styled-content style=\"fixed-case\">NSAID<\/jats:styled-content>s, and 10 times higher in women.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Drug provocation testing with <jats:styled-content style=\"fixed-case\">ASA<\/jats:styled-content> confirms the diagnosis of multiple <jats:styled-content style=\"fixed-case\">NSAID<\/jats:styled-content>\u2010induced urticaria\/angioedema in up to 92% of cases with an unequivocal clinical history, when reactions occur within 1\u00a0h and more than two different <jats:styled-content style=\"fixed-case\">NSAID<\/jats:styled-content>s are involved.<\/jats:p><\/jats:sec>","DOI":"10.1111\/cea.12013","type":"journal-article","created":{"date-parts":[[2012,9,21]],"date-time":"2012-09-21T07:52:34Z","timestamp":1348213954000},"page":"85-91","source":"Crossref","is-referenced-by-count":67,"title":["Value of the clinical history in the diagnosis of urticaria\/angioedema induced by <scp>NSAID<\/scp>s with cross\u2010intolerance"],"prefix":"10.1111","volume":"43","author":[{"given":"N.","family":"Blanca\u2010Lopez","sequence":"first","affiliation":[{"name":"Allergy Service Infanta Leonor Hospital Madrid Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M.","family":"J. 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E.","family":"Seoane Reula","sequence":"additional","affiliation":[{"name":"Allergy Service Infanta Leonor Hospital Madrid Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M.","family":"Salas","sequence":"additional","affiliation":[{"name":"Allergy Service Carlos Haya Hospital Malaga Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"G.","family":"Canto","sequence":"additional","affiliation":[{"name":"Allergy Service Infanta Leonor Hospital Madrid Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M.","family":"Blanca","sequence":"additional","affiliation":[{"name":"Allergy Service Carlos Haya Hospital Malaga Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2012,12,24]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2222.2010.03651.x"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.all.0000173785.81024.33"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/B978-0-323-05659-5.00069-3"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1398-9995.2011.02557.x"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1398-9995.1987.tb00390.x"},{"key":"e_1_2_8_7_1","first-page":"295","article-title":"Angioedema and IgE antibodies to aspirin: a case report","volume":"62","author":"Blanca M","year":"1989","journal-title":"Ann Allergy"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1067\/mai.2003.163"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1067\/mai.2001.113241"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.1034\/j.1398-9995.2000.00562.x"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1081-1206(10)62580-X"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.mcna.2010.03.005"},{"key":"e_1_2_8_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1081-1206(10)62221-1"},{"key":"e_1_2_8_14_1","doi-asserted-by":"publisher","DOI":"10.1097\/ACI.0b013e32832db943"},{"key":"e_1_2_8_15_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2222.2009.03237.x"},{"key":"e_1_2_8_16_1","doi-asserted-by":"publisher","DOI":"10.1067\/mai.2002.120563"},{"key":"e_1_2_8_17_1","doi-asserted-by":"publisher","DOI":"10.1097\/ACI.0b013e32832d5311"},{"key":"e_1_2_8_18_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1398-9995.2005.00836.x"},{"key":"e_1_2_8_19_1","doi-asserted-by":"publisher","DOI":"10.1034\/j.1398-9995.2003.00279.x"},{"key":"e_1_2_8_20_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2222.2010.03648.x"},{"key":"e_1_2_8_21_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1398-9995.2007.01409.x"},{"key":"e_1_2_8_22_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2010.12.764"},{"key":"e_1_2_8_23_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1081-1206(10)60465-6"},{"key":"e_1_2_8_24_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1398-9995.2011.02684.x"}],"container-title":["Clinical &amp; Experimental Allergy"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fcea.12013","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/cea.12013","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,11,22]],"date-time":"2023-11-22T05:20:18Z","timestamp":1700630418000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/cea.12013"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2012,12,24]]},"references-count":23,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2013,1]]}},"alternative-id":["10.1111\/cea.12013"],"URL":"https:\/\/doi.org\/10.1111\/cea.12013","archive":["Portico"],"relation":{},"ISSN":["0954-7894","1365-2222"],"issn-type":[{"value":"0954-7894","type":"print"},{"value":"1365-2222","type":"electronic"}],"subject":[],"published":{"date-parts":[[2012,12,24]]}}}