{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,1]],"date-time":"2025-11-01T08:41:10Z","timestamp":1761986470702},"reference-count":21,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2013,3,21]],"date-time":"2013-03-21T00:00:00Z","timestamp":1363824000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Clin Experimental Allergy"],"published-print":{"date-parts":[[2013,4]]},"abstract":"<jats:title>Summary<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Systemic mastocytosis (<jats:styled-content style=\"fixed-case\">SM<\/jats:styled-content>) is a clonal proliferative disorder of mast cells (<jats:styled-content style=\"fixed-case\">MC<\/jats:styled-content>) that causes pathological accumulation of mast cells in various tissues, which results in clinical symptoms (e.g. diarrhoea, urticaria) due to <jats:styled-content style=\"fixed-case\">MC<\/jats:styled-content> mediator release. Previous studies have shown that up to fifty percent of rhinitis symptoms in <jats:styled-content style=\"fixed-case\">SM<\/jats:styled-content> patients are non\u2010allergic and it has been assumed that these nasal complaints in <jats:styled-content style=\"fixed-case\">SM<\/jats:styled-content> patients are due an increased nasal mast cell burden. Nevertheless, to date there are no data supporting this hypothesis.<\/jats:p><\/jats:sec><jats:sec><jats:title>Objective<\/jats:title><jats:p>The study aims to investigate if the presence of allergy\u2010suggesting nasal complaints in non\u2010allergic <jats:styled-content style=\"fixed-case\">SM<\/jats:styled-content> patients is correlated with objective measure of nasal mast cell burden.<\/jats:p><\/jats:sec><jats:sec><jats:title>Patients and methods<\/jats:title><jats:p>Eleven adult patients with systemic mastocytosis underwent a comprehensive rhinologic work\u2010up. All patients fulfilled the clinical <jats:styled-content style=\"fixed-case\">ARIA<\/jats:styled-content> criteria for rhinitis. The allergologic work\u2010up included serological allergy testing, determination of tryptase levels (serum and nasal secretion), skin prick testing, and nasal provocation testing.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Ten out of eleven <jats:styled-content style=\"fixed-case\">SM<\/jats:styled-content> patients with clinical persistent allergic rhinitis were found to be non\u2010allergic. In these patients, the most predominant symptoms were rhinorrhea, sneezing, and itching. All three symptoms were strongly correlated with the nasal tryptase level but not to the level of serum tryptase.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion and Clinical relevance<\/jats:title><jats:p>Non\u2010allergic persistent nasal complaints in systemic mastocytosis were significantly correlated with elevated nasal tryptase level as a measure of local <jats:styled-content style=\"fixed-case\">MC<\/jats:styled-content> burden. Furthermore, elevated nasal tryptase correlated with persistent <jats:italic>rhinorrhea<\/jats:italic>,<jats:italic> sneezing<\/jats:italic>, and <jats:italic>itching<\/jats:italic> as predominant symptoms, which seems to characterize a non\u2010allergic mastocytosis\u2010associated rhinitis (<jats:styled-content style=\"fixed-case\">NAMAR<\/jats:styled-content>) in systemic mastocytosis.<\/jats:p><\/jats:sec>","DOI":"10.1111\/cea.12053","type":"journal-article","created":{"date-parts":[[2012,11,5]],"date-time":"2012-11-05T06:26:06Z","timestamp":1352096766000},"page":"406-412","source":"Crossref","is-referenced-by-count":9,"title":["Non\u2010allergic, mastocytosis\u2010associated rhinitis"],"prefix":"10.1111","volume":"43","author":[{"given":"R.","family":"Dollner","sequence":"first","affiliation":[{"name":"Department of Otorhinolaryngology, Head and Neck Surgery Division for Surgery and Clinical Neuroscience Oslo University Hospital\u2010Rikshospitalet Oslo Norway"},{"name":"Department of Otorhinolaryngology, Head and Neck Surgery Mannheim Medical School University of Heidelberg Mannheim Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"E.","family":"Taraldsrud","sequence":"additional","affiliation":[{"name":"Department of Immunology Oslo University Hospital Oslo Norway"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"K.","family":"Iversen","sequence":"additional","affiliation":[{"name":"Center for Rare Disorders Oslo University Hospital\u2010Rikshospitalet Oslo Norway"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"T.","family":"Osnes","sequence":"additional","affiliation":[{"name":"Department of Otorhinolaryngology, Head and Neck Surgery Division for Surgery and Clinical Neuroscience Oslo University Hospital\u2010Rikshospitalet Oslo Norway"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"B.","family":"Kristensen","sequence":"additional","affiliation":[{"name":"Phadia AS Aller\u00f8d Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M. F.","family":"Kramer","sequence":"additional","affiliation":[{"name":"Department of Otorhinolaryngology, Head and Neck Surgery Ludwig\u2010Maximilian University Munich, Campus Grosshadern Munich Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2013,3,21]]},"reference":[{"key":"e_1_2_6_2_1","first-page":"195","article-title":"Mast Cells in Allergic Diseases and Mastocytosis","volume":"137","author":"Marquardt DL","year":"1982","journal-title":"West J Med"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.iac.2006.05.006"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1159\/000323763"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1097\/ACI.0b013e3282a6443e"},{"key":"e_1_2_6_6_1","doi-asserted-by":"crossref","first-page":"1547","DOI":"10.1111\/j.1365-2222.2007.02804.x","article-title":"Prevalence of allergy and anaphylactic symptoms in 210 adult and pediatric patients with mastocytosis in Spain: a study of the Spanish network on mastocytosis (REMA)","volume":"37","author":"Olano D","year":"2007","journal-title":"Clin Exp Allergy"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1398-9995.2007.01620.x"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/0091-6749(94)90349-2"},{"key":"e_1_2_6_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2008.06.003"},{"key":"e_1_2_6_10_1","doi-asserted-by":"publisher","DOI":"10.1055\/s-2003-38411"},{"key":"e_1_2_6_11_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2222.2004.01989.x"},{"key":"e_1_2_6_12_1","doi-asserted-by":"publisher","DOI":"10.1107\/S0907444909034854"},{"key":"e_1_2_6_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.iac.2006.05.010"},{"key":"e_1_2_6_14_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1398-9995.1990.tb00945.x"},{"key":"e_1_2_6_15_1","doi-asserted-by":"publisher","DOI":"10.1097\/ACI.0b013e328334f5fb"},{"key":"e_1_2_6_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2011.06.012"},{"key":"e_1_2_6_17_1","first-page":"305","article-title":"Histamine intolerance\u2010like symptoms in healthy volunteers after oral provocation with liquid histamine","volume":"25","author":"W\u00f6hrl S","year":"2004","journal-title":"Allergy Asthma Proc"},{"key":"e_1_2_6_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.pharmthera.2011.01.003"},{"key":"e_1_2_6_19_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1610-0387.2011.07585.x"},{"key":"e_1_2_6_20_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2222.2006.02537.x"},{"key":"e_1_2_6_21_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2222.2007.02686.x"},{"key":"e_1_2_6_22_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.npep.2005.07.003"}],"container-title":["Clinical &amp; Experimental Allergy"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fcea.12053","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/cea.12053","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,11,22]],"date-time":"2023-11-22T04:32:06Z","timestamp":1700627526000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/cea.12053"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2013,3,21]]},"references-count":21,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2013,4]]}},"alternative-id":["10.1111\/cea.12053"],"URL":"https:\/\/doi.org\/10.1111\/cea.12053","archive":["Portico"],"relation":{},"ISSN":["0954-7894","1365-2222"],"issn-type":[{"value":"0954-7894","type":"print"},{"value":"1365-2222","type":"electronic"}],"subject":[],"published":{"date-parts":[[2013,3,21]]}}}