{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,4]],"date-time":"2026-10-04T06:47:43Z","timestamp":1791096463018,"version":"4.1.0"},"reference-count":38,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2013,3,21]],"date-time":"2013-03-21T00:00:00Z","timestamp":1363824000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Clin Experimental Allergy"],"published-print":{"date-parts":[[2013,4]]},"abstract":"<jats:title>Summary<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Hereditary angioedema attacks can be induced or worsened by oral contraceptive containing oestrogens.<\/jats:p><\/jats:sec><jats:sec><jats:title>Objectives<\/jats:title><jats:p>The purpose of this study was to assess the impact of progestin contraceptives on angioedema attacks.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We conducted a French retrospective, multi\u2010centre study of progestin contraception in women with non\u2010allergic angioedema, including hereditary angioedema type I, <jats:styled-content style=\"fixed-case\">II<\/jats:styled-content> and <jats:styled-content style=\"fixed-case\">III<\/jats:styled-content> and idiopathic angioedema. Patients were classified into four groups according to frequency of attacks. We evaluated the effects of progestin on the mean number of attacks and compared the number of patients in each group before and under progestin contraception. The influence of hormonal factors on the course of angioedema was also assessed.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Fifty\u2010five women were included: mean age was 32.1\u00a0years (16\u201352) and mean follow\u2010up 32.4\u00a0months (<jats:styled-content style=\"fixed-case\">SD<\/jats:styled-content>:29). Fourteen women were classified as type I (25.4%), two as type <jats:styled-content style=\"fixed-case\">II<\/jats:styled-content> (3.6%) and 19 as type <jats:styled-content style=\"fixed-case\">III<\/jats:styled-content> (34%) and 20 were idiopathic (36%). Seventeen patients were taking a low dose progestin\u2010only pill (<jats:styled-content style=\"fixed-case\">POP<\/jats:styled-content>), 24 antigonadotropic progestins (<jats:styled-content style=\"fixed-case\">AGP<\/jats:styled-content>) and 14 both successively. Total or partial improvement was observed in 81.8% (45\/55) of the patients and more frequently in those on an <jats:styled-content style=\"fixed-case\">AGP<\/jats:styled-content> agent (34 patients, 89.5%) than on <jats:styled-content style=\"fixed-case\">POP<\/jats:styled-content> (19 patients, 61.3%) (<jats:italic>P<\/jats:italic>\u00a0=\u00a00.013).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions &amp; Clinical Relevance<\/jats:title><jats:p>This is the first study evaluating the interest of antigonadotropic progestin contraception in a series of women with non\u2010allergic angioedema. Progestins, especially antigonadotropic progestins, appear to convey a marked benefit in most cases. Antigonadotropic progestins could thus be recommended as adjuvant treatment in childbearing women with non\u2010allergic angioedema.<\/jats:p><\/jats:sec>","DOI":"10.1111\/cea.12055","type":"journal-article","created":{"date-parts":[[2012,11,7]],"date-time":"2012-11-07T11:26:12Z","timestamp":1352287572000},"page":"475-482","source":"Crossref","is-referenced-by-count":76,"title":["Benefits of progestin contraception in non\u2010allergic angioedema"],"prefix":"10.1111","volume":"43","author":[{"given":"C.","family":"Saule","sequence":"first","affiliation":[{"name":"Gynaecological Endocrinology Unit Paris Descartes University Port Royal Cochin APHP Paris France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"I.","family":"Boccon\u2010Gibod","sequence":"additional","affiliation":[{"name":"Internal Medicine Department University Hospital of Grenoble Grenoble France"},{"name":"Centre National des Angioed\u00e8mes \u00e0 kinines (CREAK) University Hospital of Grenoble 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