{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,19]],"date-time":"2026-01-19T10:35:56Z","timestamp":1768818956064,"version":"3.49.0"},"reference-count":35,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2013,1,18]],"date-time":"2013-01-18T00:00:00Z","timestamp":1358467200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Clin Experimental Allergy"],"published-print":{"date-parts":[[2013,2]]},"abstract":"<jats:title>Summary<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Wasp venom allergy is a potentially life\u2010threatening condition with serious consequences of diagnostic error.<\/jats:p><\/jats:sec><jats:sec><jats:title>Objective<\/jats:title><jats:p>To assess whether component\u2010resolved diagnosis, using non\u2010glycosylated recombinant allergen components from yellow jacket can add to the diagnosis of wasp venom allergy.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>In total, 148 patients with a wasp (yellow jacket) allergy were included, 91 with unequivocal tests, 26 with double positivity of serum\u2010specific IgE (sIgE) to both venoms, 21 with discrepant sIgE and skin test results and finally 10 having their diagnosis only confirmed by basophil activation test (negative sIgE and skin test results). Specific IgE to recombinant species\u2010specific allergen components Ves v 1 and Ves v 5 from yellow jacket, Api m 1 from honeybee and Ves v 5 complemented wasp venom were tested by ImmunoCAP.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Overall, combined use of sIgE to <jats:styled-content style=\"fixed-case\">rV<\/jats:styled-content>es v 1 and <jats:styled-content style=\"fixed-case\">rV<\/jats:styled-content>es v 5 allowed correct diagnosis in 139 of the 148 patients (94%) and <jats:styled-content style=\"fixed-case\">rA<\/jats:styled-content>pi m 1 was demonstrable in only one patient. Supplementing the traditional yellow jacket allergosorbent with <jats:styled-content style=\"fixed-case\">rV<\/jats:styled-content>es v 5 allowed to correctly diagnose wasp allergy in patients sensitized to Ves v 5 but demonstrating a negative sIgE to wasp venom.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Component\u2010resolved diagnoses with the wasp\u2010specific recombinant allergen components Ves v 1 and Ves v 5 is a reliable method to diagnose yellow jacket allergy and can help to take out the sting of difficult cases. However, as the number of patients with doubt after conventional tests is small, larger collaborative studies are needed to draw more definitive conclusions. Whether the <jats:styled-content style=\"fixed-case\">rV<\/jats:styled-content>es v 5 supplemented yellow jacket allergosorbent constitutes an asset in the diagnostic management of wasp venom allergy remains to be further established.<\/jats:p><\/jats:sec>","DOI":"10.1111\/cea.12057","type":"journal-article","created":{"date-parts":[[2012,11,8]],"date-time":"2012-11-08T08:26:32Z","timestamp":1352363192000},"page":"255-261","source":"Crossref","is-referenced-by-count":55,"title":["Component\u2010resolved diagnosis of wasp (yellow jacket) venom allergy"],"prefix":"10.1111","volume":"43","author":[{"given":"D. G.","family":"Ebo","sequence":"first","affiliation":[{"name":"Faculty of Medicine and Health Science Department of Immunology Allergology Rheumatology University of Antwerp Antwerpen (Belgium) and Antwerp University Hospital Antwerpen Belgium"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M.","family":"Faber","sequence":"additional","affiliation":[{"name":"Faculty of Medicine and Health Science Department of Immunology Allergology Rheumatology University of Antwerp Antwerpen (Belgium) and Antwerp University Hospital Antwerpen Belgium"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"V.","family":"Sabato","sequence":"additional","affiliation":[{"name":"Faculty of Medicine and Health Science Department of Immunology Allergology Rheumatology University of Antwerp Antwerpen (Belgium) and Antwerp University Hospital Antwerpen Belgium"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J.","family":"Leysen","sequence":"additional","affiliation":[{"name":"Faculty of Medicine and Health Science Department of Immunology Allergology Rheumatology University of Antwerp Antwerpen (Belgium) and Antwerp University Hospital Antwerpen Belgium"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"C. 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