{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,13]],"date-time":"2026-05-13T19:50:25Z","timestamp":1778701825444,"version":"3.51.4"},"reference-count":15,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2013,1,18]],"date-time":"2013-01-18T00:00:00Z","timestamp":1358467200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Clin Experimental Allergy"],"published-print":{"date-parts":[[2013,2]]},"abstract":"<jats:title>Summary<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>The Sabin vaccine is used world\u2010wide, and most children with food allergies receive it without incident. However, in the 2009 vaccination campaign conducted in Argentina, four children experienced immediate\u2010type hypersensitivity reactions following vaccination.<\/jats:p><\/jats:sec><jats:sec><jats:title>Objective<\/jats:title><jats:p>We aimed to review the medical history of the affected children, study their allergic condition after the episodes and analyse the presence of allergenic vaccine components.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Patients were selected based on their immediate allergic reactions following vaccination. They were assessed for allergies to cow's milk and hen's egg. The presence of cow's milk proteins in the vaccine was tested by various immunoassays involving cow's milk\u2010 or \u03b1\u2010lactalbumin\u2010specific polyclonal rabbit antiserum and patient sera.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>All of the patients had a history of milk allergy, and no history or current evidence of egg hypersensitivity was found. Levels of cow's milk\u2010 and Sabin vaccine\u2010specific IgE were increased, and the result of a skin prick test with cow's milk proteins or the Sabin vaccine was positive in each patient. In addition, an <jats:styled-content style=\"fixed-case\">ELISA<\/jats:styled-content> using specific rabbit antiserum detected \u03b1\u2010lactalbumin in the Sabin vaccine. When \u03b1\u2010lactalbumin was employed as a soluble inhibitor in a competitive <jats:styled-content style=\"fixed-case\">ELISA<\/jats:styled-content>, binding to vaccine\u2010coated plates by cow's milk\u2010 or \u03b1\u2010lactalbumin\u2010specific rabbit antiserum or by patient serum containing IgE was inhibited.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>We have demonstrated that these patients were allergic to cow's milk, and had circulating and mast cell\u2010bound IgE antibodies specific to cow's milk proteins. We found that the Sabin vaccine contained \u03b1\u2010lactalbumin, which may have been responsible for the reactions elicited following vaccination with the Sabin and dual viral vaccines in combination.<\/jats:p><\/jats:sec>","DOI":"10.1111\/cea.12059","type":"journal-article","created":{"date-parts":[[2012,11,15]],"date-time":"2012-11-15T22:55:45Z","timestamp":1353020145000},"page":"249-254","source":"Crossref","is-referenced-by-count":36,"title":["Hypersensitivity reactions to the Sabin vaccine in children with cow's milk allergy"],"prefix":"10.1111","volume":"43","author":[{"given":"C. A. S.","family":"Parisi","sequence":"first","affiliation":[{"name":"Secci\u00f3n de Alergia Pedi\u00e1trica Servicio de Cl\u00ednica Pedi\u00e1trica Secci\u00f3n Alergia Adultos Servicio de Cl\u00ednica M\u00e9dica Hospital Italiano de Buenos Aires Buenos Aires Argentina"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"P. L.","family":"Smaldini","sequence":"additional","affiliation":[{"name":"Laboratorio de Investigaciones del Sistema Inmune Facultad de Ciencias Exactas Universidad Nacional de La Plata La Plata Argentina"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M. E.","family":"Gervasoni","sequence":"additional","affiliation":[{"name":"Hospital de Ni\u00f1os V\u00edctor J Vilela Servicio de Alergia e Inmunolog\u00eda Rosario Argentina"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J. F.","family":"Maspero","sequence":"additional","affiliation":[{"name":"Fundaci\u00f3n CIDEA Buenos Aires Argentina"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"G. H.","family":"Docena","sequence":"additional","affiliation":[{"name":"Laboratorio de Investigaciones del Sistema Inmune Facultad de Ciencias Exactas Universidad Nacional de La Plata La Plata Argentina"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2013,1,18]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1097\/00006454-200012000-00002"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1542\/peds.112.4.815"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.3109\/07853899908995890"},{"issue":"2","key":"e_1_2_6_5_1","doi-asserted-by":"crossref","first-page":"S116","DOI":"10.1016\/j.jaci.2009.08.028","article-title":"Food allergy","volume":"125","author":"Sicherer SH","year":"2010","journal-title":"J Allergy Clin Immunol"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1651-2227.2011.02165.x"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2249.2002.t01-1-01935.x"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.1034\/j.1398-9995.2002.1o3219.x"},{"key":"e_1_2_6_9_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2222.2008.03062.x"},{"key":"e_1_2_6_10_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2222.2000.00836.x"},{"key":"e_1_2_6_11_1","doi-asserted-by":"publisher","DOI":"10.1586\/erv.09.40"},{"key":"e_1_2_6_12_1","doi-asserted-by":"publisher","DOI":"10.1136\/jcp.2006.037457"},{"key":"e_1_2_6_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.vaccine.2011.04.026"},{"key":"e_1_2_6_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2011.04.046"},{"key":"e_1_2_6_15_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1398-9995.1996.tb04639.x"},{"key":"e_1_2_6_16_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2222.2010.03557.x"}],"container-title":["Clinical &amp; Experimental Allergy"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fcea.12059","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/cea.12059","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,11,22]],"date-time":"2023-11-22T04:25:31Z","timestamp":1700627131000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/cea.12059"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2013,1,18]]},"references-count":15,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2013,2]]}},"alternative-id":["10.1111\/cea.12059"],"URL":"https:\/\/doi.org\/10.1111\/cea.12059","archive":["Portico"],"relation":{},"ISSN":["0954-7894","1365-2222"],"issn-type":[{"value":"0954-7894","type":"print"},{"value":"1365-2222","type":"electronic"}],"subject":[],"published":{"date-parts":[[2013,1,18]]}}}