{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,3]],"date-time":"2026-10-03T14:36:36Z","timestamp":1791038196644,"version":"4.1.0"},"reference-count":25,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2013,2,17]],"date-time":"2013-02-17T00:00:00Z","timestamp":1361059200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Clin Experimental Allergy"],"published-print":{"date-parts":[[2013,3]]},"abstract":"<jats:title>Summary<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Few studies have focused on pollen exposure and asthma in children. None have examined associations between persistent exposure to pollen in infancy and aeroallergen sensitisation and asthma in childhood.<\/jats:p><\/jats:sec><jats:sec><jats:title>Objectives<\/jats:title><jats:p>To examine the association between higher ambient levels of pollen in the first 3\u20136\u00a0months of life and risk of eczema, sensitization to food and aeroallergens at 2\u00a0years and asthma or hayfever at age 6\u20137\u00a0years combined.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Using a birth cohort of 620 infants with a family history of allergic disease born between 1990 and 1994, we examined risk of eczema or allergic sensitization (<jats:styled-content style=\"fixed-case\">SPT<\/jats:styled-content> &gt;\u00a03\u00a0mm to at least one of cow's milk, egg white, peanut, house dust\u2010mite, rye grass, and cat dander) by age 2 and asthma or hayfever at age 6\u20137. Daily ambient levels of pollen were measured during this period.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Cumulative exposure to pollen concentrations up to 6\u00a0months was associated with aeroallergen sensitization with the highest risk occurring at 3\u00a0months (<jats:styled-content style=\"fixed-case\">aOR<\/jats:styled-content>\u00a0=\u00a01.34, 95% CI 1.06\u20131.72). Cumulative exposure to pollen up to 3\u00a0months was also associated with hayfever (<jats:styled-content style=\"fixed-case\">aOR<\/jats:styled-content>\u00a0=\u00a01.14, 95% CI 1.009\u20131.29) and between 4 and 6\u00a0months exposure with asthma only (<jats:styled-content style=\"fixed-case\">aOR<\/jats:styled-content>=1.35, 95% CI 1.07\u20131.72).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Persistent pollen exposure in infancy appears to increase the risk of asthma and hayfever in children. These results support the hypothesis that there is a critical window of opportunity in early development which may be important for modification of allergic outcomes.<\/jats:p><\/jats:sec>","DOI":"10.1111\/cea.12071","type":"journal-article","created":{"date-parts":[[2012,12,13]],"date-time":"2012-12-13T13:50:28Z","timestamp":1355406628000},"page":"337-343","source":"Crossref","is-referenced-by-count":44,"title":["Persistent pollen exposure during infancy is associated with increased risk of subsequent childhood asthma and hayfever"],"prefix":"10.1111","volume":"43","author":[{"given":"B.","family":"Erbas","sequence":"first","affiliation":[{"name":"School of Public Health La Trobe University Melbourne VIC Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A. J.","family":"Lowe","sequence":"additional","affiliation":[{"name":"Centre for Molecular, Environmental, Genetic &amp; Analytic Epidemiology School of Population Health The University of Melbourne Melbourne VIC Australia"},{"name":"Murdoch Children's Research Institute Royal Children's Hospital Melbourne VIC Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C. J.","family":"Lodge","sequence":"additional","affiliation":[{"name":"Centre for Molecular, Environmental, Genetic &amp; Analytic Epidemiology School of Population Health The University of Melbourne Melbourne VIC Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M. C.","family":"Matheson","sequence":"additional","affiliation":[{"name":"Centre for Molecular, Environmental, Genetic &amp; Analytic Epidemiology School of Population Health The University of Melbourne Melbourne VIC Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C. S.","family":"Hosking","sequence":"additional","affiliation":[{"name":"Department of Paediatrics John Hunter Children's Hospital Newcastle NSW Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"D. J.","family":"Hill","sequence":"additional","affiliation":[{"name":"Murdoch Children's Research Institute Royal Children's Hospital Melbourne VIC Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"D.","family":"Vicendese","sequence":"additional","affiliation":[{"name":"School of Public Health La Trobe University Melbourne VIC Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"K. J.","family":"Allen","sequence":"additional","affiliation":[{"name":"Murdoch Children's Research Institute Royal Children's Hospital Melbourne VIC Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M. J.","family":"Abramson","sequence":"additional","affiliation":[{"name":"Department of Epidemiology and Preventive Medicine Monash University Melbourne VIC Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S. 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