{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,12]],"date-time":"2026-01-12T08:57:26Z","timestamp":1768208246980,"version":"3.49.0"},"reference-count":15,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2013,6,21]],"date-time":"2013-06-21T00:00:00Z","timestamp":1371772800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Clin Experimental Allergy"],"published-print":{"date-parts":[[2013,7]]},"abstract":"Summary<\/jats:title>Background<\/jats:title>Although the treatment of allergic rhinitis (AR<\/jats:styled-content>) is now well established, its impact on severity has not yet been evaluated.<\/jats:p><\/jats:sec>Objective<\/jats:title>The aim was to analyse specialist\u2010based treatment on AR<\/jats:styled-content> severity, nasal symptoms and quality of life.<\/jats:p><\/jats:sec>Methods<\/jats:title>A longitudinal observational, prospective, multi\u2010centre study with 4\u00a0weeks of follow\u2010up was carried out by 141 allergologists and ENT<\/jats:styled-content> specialists in Spain. Selection criteria were adult patients with AR<\/jats:styled-content>, clinically diagnosed at least 2\u00a0years before, with a total nasal symptom score (TNSS<\/jats:styled-content>) \u22655, not receiving either antihistamines within the previous week or nasal corticosteroids during the 2 previous weeks. Disease severity using both original Allergic Rhinitis and its Impact on Asthma (o\u2010ARIA<\/jats:styled-content>) and modified (m\u2010ARIA<\/jats:styled-content>) classifications, nasal symptoms, and Quality of Life (ESPRINT<\/jats:styled-content>\u201015), were measured at baseline and after 4\u00a0weeks of treatment.<\/jats:p><\/jats:sec>Results<\/jats:title>Among the recruited AR<\/jats:styled-content> patients (n<\/jats:italic>\u00a0=\u00a0707, 58% women), 39.3% were intermittent and 60.7% persistent, 40.2% had asthma and 61.4% conjunctivitis. Most patients were treated with second generation antihistamines in monotherapy (63.2%) or in combination with intranasal corticosteroids (31.5%). While using o\u2010ARIA<\/jats:styled-content>, 96.9% of patients had \u2018moderate\/severe\u2019 AR<\/jats:styled-content>, the m\u2010ARIA<\/jats:styled-content> discriminated between \u2018moderate\u2019 (55.4%) and severe (41.5%) AR<\/jats:styled-content>, at baseline. After 4\u00a0weeks of treatment, improvement was found on disease severity (P<\/jats:italic>\u00a0<\u00a00.0001), TNSS<\/jats:styled-content> (8.2\u00a0\u00b1\u00a01.8 vs. 3.5\u00a0\u00b1\u00a02.3, P<\/jats:italic>\u00a0<\u00a00.0001) and Quality of Life (ESPRINT<\/jats:styled-content>\u201015 global score: 3.0\u00a0\u00b1\u00a01.2 vs. 1.1\u00a0\u00b1\u00a01.0, P<\/jats:italic>\u00a0<\u00a00.0001).<\/jats:p><\/jats:sec>Conclusions<\/jats:title>Specialist\u2010based treatment reduces AR<\/jats:styled-content> severity, evaluated using the m\u2010ARIA<\/jats:styled-content> classification for the first time, in addition to the improvement of nasal symptoms and quality of life.<\/jats:p><\/jats:sec>Clinical relevance<\/jats:title>Specialist\u2010based treatment improves AR<\/jats:styled-content> severity, in addition to nasal symptoms and quality of life. However, no matter the treatment option some AR<\/jats:styled-content> patients remain severe and need further follow\u2010up.<\/jats:p><\/jats:sec>","DOI":"10.1111\/cea.12081","type":"journal-article","created":{"date-parts":[[2013,1,7]],"date-time":"2013-01-07T19:47:10Z","timestamp":1357588030000},"page":"723-729","source":"Crossref","is-referenced-by-count":16,"title":["Specialist\u2010based treatment reduces the severity of allergic rhinitis"],"prefix":"10.1111","volume":"43","author":[{"given":"J.","family":"Mullol","sequence":"first","affiliation":[{"name":"Unitat de Rinologia i Clinica de l'Olfacte Servei d'Otorinolaringologia Hospital Cl\u00ednic Barcelona Catalonia Spain"},{"name":"Immunoal.l\u00e8rgia Respirat\u00f2ria Cl\u00ednica i Experimental (IRCE) Institut d'Investigacions Biom\u00e8diques August Pi i Sunyer (IDIBAPS) Barcelona Catalonia Spain"},{"name":"Centro de Investigaci\u00f3n Biom\u00e9dica en Red en Enfermedades Respiratorias (CIBERES) Barcelona Catalonia Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J.","family":"Bartra","sequence":"additional","affiliation":[{"name":"Unitat d'Al.l\u00e8rgia Servei de Pneumologia i Al.l\u00e8rgia Respirat\u00f2ria Hospital Cl\u00ednic Barcelona Catalonia Spain"},{"name":"Immunoal.l\u00e8rgia Respirat\u00f2ria Cl\u00ednica i Experimental (IRCE) Institut d'Investigacions Biom\u00e8diques August Pi i Sunyer (IDIBAPS) Barcelona Catalonia Spain"},{"name":"Centro de Investigaci\u00f3n Biom\u00e9dica en Red en Enfermedades Respiratorias (CIBERES) Barcelona Catalonia Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A.","family":"del Cuvillo","sequence":"additional","affiliation":[{"name":"Secci\u00f3n de Rinolog\u00eda UGC ORL Hospital de J\u00e9rez C\u00e1diz Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"I.","family":"Izquierdo","sequence":"additional","affiliation":[{"name":"Unidad de Desarrollo Clinico J Uriach y C\u00eda SA Palau\u2010Solit\u00e0 i Plegamans Barcelona Catalonia Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"R.","family":"Mu\u00f1oz\u2010Cano","sequence":"additional","affiliation":[{"name":"Unitat d'Al.l\u00e8rgia Servei de Pneumologia i Al.l\u00e8rgia Respirat\u00f2ria Hospital Cl\u00ednic Barcelona Catalonia Spain"},{"name":"Immunoal.l\u00e8rgia Respirat\u00f2ria Cl\u00ednica i Experimental (IRCE) Institut d'Investigacions Biom\u00e8diques August Pi i Sunyer (IDIBAPS) Barcelona Catalonia Spain"},{"name":"Centro de Investigaci\u00f3n Biom\u00e9dica en Red en Enfermedades Respiratorias (CIBERES) Barcelona Catalonia Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A.","family":"Valero","sequence":"additional","affiliation":[{"name":"Unitat d'Al.l\u00e8rgia Servei de Pneumologia i Al.l\u00e8rgia Respirat\u00f2ria Hospital Cl\u00ednic Barcelona Catalonia Spain"},{"name":"Immunoal.l\u00e8rgia Respirat\u00f2ria Cl\u00ednica i Experimental (IRCE) Institut d'Investigacions Biom\u00e8diques August Pi i Sunyer (IDIBAPS) Barcelona Catalonia Spain"},{"name":"Centro de Investigaci\u00f3n Biom\u00e9dica en Red en Enfermedades Respiratorias (CIBERES) Barcelona Catalonia Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2013,6,21]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1398-9995.2007.01620.x"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1034\/j.1398-9995.2003.00076.x"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2006.05.015"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1398-9995.2010.02374.x"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1398-9995.2006.01276.x"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2007.04.006"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1398-9995.2010.02410.x"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1081-1206(10)62160-6"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1524-4733.2007.00202.x"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1398-9995.2007.01552.x"},{"key":"e_1_2_7_12_1","first-page":"396","article-title":"Reference values for facilitating the interpretation of the ESPRINT\u201015 Questionnaire (Spanish version)","volume":"19","author":"Valero A","year":"2009","journal-title":"J Investig Allergol Clin Immunol"},{"key":"e_1_2_7_13_1","first-page":"201","article-title":"Validation of ARIA duration and severity classifications in Spanish allergic rhinitis patients \u2010 The ADRIAL cohort study","volume":"48","author":"Cuvillo A","year":"2010","journal-title":"Rhinology"},{"key":"e_1_2_7_14_1","first-page":"35","article-title":"Prevalence and characteristics of rhinitis in asthmatic patients attended in primary care in spain (RINOASMAIR Study)","volume":"48","author":"Castillo JA","year":"2010","journal-title":"Rhinology"},{"key":"e_1_2_7_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2009.06.027"},{"key":"e_1_2_7_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2010.06.034"}],"container-title":["Clinical & Experimental 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