{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T03:25:57Z","timestamp":1791257157954,"version":"4.1.0"},"reference-count":21,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2013,5,28]],"date-time":"2013-05-28T00:00:00Z","timestamp":1369699200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Clin Experimental Allergy"],"published-print":{"date-parts":[[2013,6]]},"abstract":"<jats:title>Summary<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>The administration of biological agents is potentially affected by IgE\u2010mediated infusion reactions.<\/jats:p><\/jats:sec><jats:sec><jats:title>Objective<\/jats:title><jats:p>The aim of the study was to evaluate the utility of skin testing in patients who have experienced infliximab (<jats:styled-content style=\"fixed-case\">IFX<\/jats:styled-content>)\u2010related reactions.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Thirty patients with previous immediate hypersensitivity reaction to <jats:styled-content style=\"fixed-case\">IFX<\/jats:styled-content>, 20 disease\u2010matched non exposed subjects, 15 <jats:styled-content style=\"fixed-case\">IFX<\/jats:styled-content>\u2010treated disease\u2010matched tolerant patients and 15 <jats:styled-content style=\"fixed-case\">IFX<\/jats:styled-content> non\u2010responder patients were enrolled. Non\u2010isotype\u2010specific and IgE anti\u2010drug antibodies (<jats:styled-content style=\"fixed-case\">ADA<\/jats:styled-content>s) were measured by a double\u2010capture <jats:styled-content style=\"fixed-case\">ELISA<\/jats:styled-content> kit and Immuno<jats:styled-content style=\"fixed-case\">CAP<\/jats:styled-content> assay, respectively. Prick and intra\u2010dermal tests were carried out with the commercial <jats:styled-content style=\"fixed-case\">IFX<\/jats:styled-content> preparation serially diluted.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Skin testing, performed in 23 of 30 reactive patients, resulted positive in 7 of them (30.4%), whereas no positivity was found in other groups of patients. The majority of reactive patients displayed non\u2010isotype\u2010specific <jats:styled-content style=\"fixed-case\">ADA<\/jats:styled-content>s (23\/30, 76.6%) and the presence of anti\u2010<jats:styled-content style=\"fixed-case\">IFX<\/jats:styled-content> IgE antibodies was detected in 6 of them (26%). All 6 IgE\u2010positive reactive patients showed skin testing positivity. One reactive <jats:styled-content style=\"fixed-case\">ADA<\/jats:styled-content>s\u2010positive patient who resulted skin test positive, with no detectable serum <jats:styled-content style=\"fixed-case\">IFX<\/jats:styled-content>\u2010specific IgE <jats:styled-content style=\"fixed-case\">ADA<\/jats:styled-content>s, was also found. Skin testing positivity was associated with severe and early reactions (within the 3<jats:sup>rd<\/jats:sup> dose). No unexpected adverse reactions to skin testing were recorded.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions and Clinical Relevance<\/jats:title><jats:p>This study shows that about 30% of reactive patients display skin testing positivity. They usually develop severe reactions, mainly during the first administrations of <jats:styled-content style=\"fixed-case\">IFX<\/jats:styled-content>. The specificity and the safety of skin testing procedure for this biological agent are also confirmed.<\/jats:p><\/jats:sec>","DOI":"10.1111\/cea.12098","type":"journal-article","created":{"date-parts":[[2013,2,14]],"date-time":"2013-02-14T16:25:06Z","timestamp":1360859106000},"page":"659-664","source":"Crossref","is-referenced-by-count":66,"title":["Allergological <i>in vitro<\/i> and <i>in vivo<\/i> evaluation of patients with hypersensitivity reactions to infliximab"],"prefix":"10.1111","volume":"43","author":[{"given":"A.","family":"Matucci","sequence":"first","affiliation":[{"name":"Immunoallergology Unit Azienda Ospedaliero\u2010Universitaria Careggi Florence Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S.","family":"Pratesi","sequence":"additional","affiliation":[{"name":"Center for Research, Transfer and High Education DENOTHE University of Florence Florence Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"G.","family":"Petroni","sequence":"additional","affiliation":[{"name":"Center for Research, Transfer and High Education DENOTHE University of Florence Florence Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"F.","family":"Nencini","sequence":"additional","affiliation":[{"name":"Center for Research, Transfer and High Education DENOTHE University of Florence Florence Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"G.","family":"Virgili","sequence":"additional","affiliation":[{"name":"Oto\u2010Neuro\u2010Ophthalmological Surgical Sciences Unit Azienda Ospedaliero\u2010Universitaria Careggi Florence Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M.","family":"Milla","sequence":"additional","affiliation":[{"name":"Gastroenterology Unit Azienda Ospedaliero\u2010Universitaria Careggi Florence Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"E.","family":"Maggi","sequence":"additional","affiliation":[{"name":"Center for Research, Transfer and High Education DENOTHE University of Florence Florence Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A.","family":"Vultaggio","sequence":"additional","affiliation":[{"name":"Immunoallergology Unit Azienda Ospedaliero\u2010Universitaria Careggi Florence Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2013,5,28]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaut.2011.08.002"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1093\/rheumatology\/ker124"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa074943"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1398-9995.2009.02280.x"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1159\/000336839"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.clinthera.2010.07.021"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2010.05.004"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2009.09.009"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2004.04.029"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpba.2008.09.020"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2004.12.1131"},{"key":"e_1_2_7_13_1","doi-asserted-by":"publisher","DOI":"10.1586\/eci.10.90"},{"key":"e_1_2_7_14_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1398-9995.2004.00532.x"},{"key":"e_1_2_7_15_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2222.2009.03361.x"},{"key":"e_1_2_7_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2010.11.047"},{"key":"e_1_2_7_17_1","doi-asserted-by":"publisher","DOI":"10.1093\/rheumatology\/kem261"},{"key":"e_1_2_7_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2007.07.033"},{"key":"e_1_2_7_19_1","doi-asserted-by":"publisher","DOI":"10.1097\/ACI.0b013e3283464bcd"},{"key":"e_1_2_7_20_1","doi-asserted-by":"publisher","DOI":"10.1136\/ard.2006.057406"},{"key":"e_1_2_7_21_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1398-9995.2008.01713.x"},{"key":"e_1_2_7_22_1","doi-asserted-by":"publisher","DOI":"10.1177\/039463200802100214"}],"container-title":["Clinical &amp; 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