{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,13]],"date-time":"2026-06-13T14:13:39Z","timestamp":1781360019515,"version":"3.54.1"},"reference-count":34,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2013,7,29]],"date-time":"2013-07-29T00:00:00Z","timestamp":1375056000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Clin Experimental Allergy"],"published-print":{"date-parts":[[2013,8]]},"abstract":"<jats:title>Summary<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Interleukin\u201023 (<jats:styled-content style=\"fixed-case\">IL<\/jats:styled-content>\u201023) and <jats:styled-content style=\"fixed-case\">IL<\/jats:styled-content>\u201017 may be involved in the pathogenesis of allergic rhinitis (<jats:styled-content style=\"fixed-case\">AR<\/jats:styled-content>). However, a differentiation of the role of <jats:styled-content style=\"fixed-case\">IL<\/jats:styled-content>\u201023 and <jats:styled-content style=\"fixed-case\">IL<\/jats:styled-content>\u201017 has not been performed yet.<\/jats:p><\/jats:sec><jats:sec><jats:title>Objective<\/jats:title><jats:p>The aim of this study was therefore to investigate the immunomodulatory effects of <jats:styled-content style=\"fixed-case\">IL<\/jats:styled-content>\u201023 and <jats:styled-content style=\"fixed-case\">IL<\/jats:styled-content>\u201017, using a mouse model of <jats:styled-content style=\"fixed-case\">AR<\/jats:styled-content>.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Anti\u2010<jats:styled-content style=\"fixed-case\">IL<\/jats:styled-content>\u201023p19 and anti\u2010<jats:styled-content style=\"fixed-case\">IL<\/jats:styled-content>\u201017 Abs were administrated intranasally during rechallenge in ovalbumin (<jats:styled-content style=\"fixed-case\">OVA<\/jats:styled-content>)\u2010induced <jats:styled-content style=\"fixed-case\">AR<\/jats:styled-content> in <jats:styled-content style=\"fixed-case\">BALB<\/jats:styled-content>\/c mice. Immunomodulatory effects were evaluated by measuring nasal rubbing and sneezing occurrences, serum <jats:styled-content style=\"fixed-case\">OVA<\/jats:styled-content>\u2010specific antibodies, Th2 responses (i.e. expression of <jats:styled-content style=\"fixed-case\">IL<\/jats:styled-content>\u20104, <jats:styled-content style=\"fixed-case\">IL<\/jats:styled-content>\u20105, <jats:styled-content style=\"fixed-case\">IL<\/jats:styled-content>\u201013 and <jats:styled-content style=\"fixed-case\">IFN<\/jats:styled-content>\u2010\u03b3 genes in nasal mucosa, <jats:styled-content style=\"fixed-case\">IL<\/jats:styled-content>\u20104<jats:sup>+<\/jats:sup>\u00a0<jats:styled-content style=\"fixed-case\">CD<\/jats:styled-content>4<jats:sup>+<\/jats:sup> T cells percentages in superficial cervical lymph nodes (<jats:styled-content style=\"fixed-case\">LN<\/jats:styled-content>s) and <jats:styled-content style=\"fixed-case\">IL<\/jats:styled-content>\u20104 production in <jats:styled-content style=\"fixed-case\">LN<\/jats:styled-content>s stimulated with <jats:styled-content style=\"fixed-case\">OVA <\/jats:styled-content><jats:italic>in vitro<\/jats:italic>), and neutrophil, eosinophil and mast cell recruitment into the nasal mucosa.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The effect of <jats:styled-content style=\"fixed-case\">IL<\/jats:styled-content>\u201017 antagonism was limited to attenuating the Th2 responses and neutrophil and eosinophil infiltration. In contrast, treatment with anti\u2010<jats:styled-content style=\"fixed-case\">IL<\/jats:styled-content>\u201023p19 Abs markedly reduced nasal rubbing and sneezing events, Th2 responses, serum <jats:styled-content style=\"fixed-case\">OVA<\/jats:styled-content>\u2010specific IgE and IgG1 levels, as well as mucosal neutrophil, eosinophil and mast cell infiltration.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion and Clinical Relevance<\/jats:title><jats:p><jats:styled-content style=\"fixed-case\">IL<\/jats:styled-content>\u201017 and <jats:styled-content style=\"fixed-case\">IL<\/jats:styled-content>\u201023 may play a pathogenic role in an established <jats:styled-content style=\"fixed-case\">AR<\/jats:styled-content> mouse model; with a more pronounced contribution of <jats:styled-content style=\"fixed-case\">IL<\/jats:styled-content>\u201023 than <jats:styled-content style=\"fixed-case\">IL<\/jats:styled-content>\u201017.<\/jats:p><\/jats:sec>","DOI":"10.1111\/cea.12123","type":"journal-article","created":{"date-parts":[[2013,4,8]],"date-time":"2013-04-08T15:29:12Z","timestamp":1365434952000},"page":"956-966","source":"Crossref","is-referenced-by-count":49,"title":["Immunomodulatory effects of <scp>IL<\/scp>\u201023 and <scp>IL<\/scp>\u201017 in a mouse model of allergic rhinitis"],"prefix":"10.1111","volume":"43","author":[{"given":"M.","family":"Wang","sequence":"first","affiliation":[{"name":"Department of Otolaryngology Head and Neck Surgery Beijing TongRen Hospital Capital Medical University Beijing China"},{"name":"Key Laboratory of Otolaryngology Head and Neck Surgery (Ministry of Education of China) Beijing Institute of Otolaryngology Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"W.","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology Head and Neck Surgery Beijing 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