{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T19:31:45Z","timestamp":1790710305465,"version":"4.1.0"},"reference-count":37,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2013,8,20]],"date-time":"2013-08-20T00:00:00Z","timestamp":1376956800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Clin Experimental Allergy"],"published-print":{"date-parts":[[2013,9]]},"abstract":"Summary<\/jats:title>\n \n Background<\/jats:title>\n \n The role of probiotics in prevention of allergic disease is still not clear; efficacy may depend on the timing, dose, duration, and specific probiotic used. Using a double\u2010blind randomized placebo\u2010controlled trial (Australian New Zealand Clinical Trials Registry:\n ACTRN<\/jats:styled-content>\n 12607000518460), we have shown that in a high\u2010risk birth cohort, maternal supplementation from 35\u00a0weeks gestation until 6\u00a0months if breastfeeding and infant supplementation from birth until 2\u00a0years with\n Lactobacillus rhamnosus<\/jats:italic>\n HN<\/jats:styled-content>\n 001 (\n HN<\/jats:styled-content>\n 001) (6\u00a0\u00d7\u00a010\n 9<\/jats:sup>\n \u00a0cfu\/day) halved the cumulative prevalence of eczema at 2 and 4\u00a0years.\n Bifidobacterium animalis<\/jats:italic>\n subsp\n lactis<\/jats:italic>\n HN<\/jats:styled-content>\n 019 (\n HN<\/jats:styled-content>\n 019) (9\u00a0\u00d7\u00a010\n 9<\/jats:sup>\n \u00a0cfu\/day) had no significant effect.\n <\/jats:p>\n <\/jats:sec>\n \n Objective<\/jats:title>\n \n To determine whether differences in effects of\n HN<\/jats:styled-content>\n 001 and\n HN<\/jats:styled-content>\n 019 on eczema persist to age 6\u00a0years, and to investigate effects on sensitization.\n <\/jats:p>\n <\/jats:sec>\n \n Methods<\/jats:title>\n \n Standard procedures were used to assess eczema (The\n UK<\/jats:styled-content>\n Working Party's Criteria), eczema severity (\n SCORAD<\/jats:styled-content>\n ), atopic sensitization [skin prick tests (\n SPT<\/jats:styled-content>\n ), total and specific IgE] and standard questions used for asthma, wheeze, and rhinoconjunctivitis.\n <\/jats:p>\n <\/jats:sec>\n \n Results<\/jats:title>\n \n HN<\/jats:styled-content>\n 001 was associated with significantly lower cumulative prevalence of eczema (\n HR<\/jats:styled-content>\n \u00a0=\u00a00.56, 95%\n CI<\/jats:styled-content>\n 0.39\u20130.80),\n SCORAD<\/jats:styled-content>\n \u00a0\u2265\u00a010 (\n HR<\/jats:styled-content>\n \u00a0=\u00a00.69, 0.49\u20130.98) and\n SPT<\/jats:styled-content>\n sensitization (\n HR<\/jats:styled-content>\n \u00a0=\u00a00.69, 95%\n CI<\/jats:styled-content>\n 0.48\u20130.99). The point prevalence of eczema (\n RR<\/jats:styled-content>\n \u00a0=\u00a00.66, 95%\n CI<\/jats:styled-content>\n 0.44\u20131.00),\n SCORAD<\/jats:styled-content>\n \u00a0\u2265\u00a010 (\n RR<\/jats:styled-content>\n \u00a0=\u00a00.62, 95%\n CI<\/jats:styled-content>\n 0.38\u20131.01) and\n SPT<\/jats:styled-content>\n sensitization (\n RR<\/jats:styled-content>\n \u00a0=\u00a00.72, 95%\n CI<\/jats:styled-content>\n 0.53\u20131.00) were also reduced among children taking\n HN<\/jats:styled-content>\n 001.\n HN<\/jats:styled-content>\n 019 had no significant effect on any outcome.\n <\/jats:p>\n <\/jats:sec>\n \n Conclusion and Clinical Relevance<\/jats:title>\n \n This study provides evidence for the efficacy of the probiotic\n L. rhamnosus<\/jats:italic>\n HN<\/jats:styled-content>\n 001 in preventing the development of eczema and possibly also atopic sensitization in high risk infants to age 6\u00a0years. The absence of a similar effect for\n HN<\/jats:styled-content>\n 019 indicates that benefits may be species specific.\n <\/jats:p>\n <\/jats:sec>","DOI":"10.1111\/cea.12154","type":"journal-article","created":{"date-parts":[[2013,6,5]],"date-time":"2013-06-05T14:00:07Z","timestamp":1370440807000},"page":"1048-1057","source":"Crossref","is-referenced-by-count":107,"title":["Early supplementation with\n Lactobacillus rhamnosus<\/i>\n \u00a0\n HN<\/scp>\n 001 reduces eczema prevalence to 6\u00a0years: does it also reduce atopic sensitization?"],"prefix":"10.1111","volume":"43","author":[{"given":"K.","family":"Wickens","sequence":"first","affiliation":[{"name":"Wellington Asthma Research Group Wellington School of Medicine and Health Sciences University of Otago Wellington New Zealand"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"T. V.","family":"Stanley","sequence":"additional","affiliation":[{"name":"Department of Paediatrics Wellington School of Medicine and Health Sciences University of Otago Wellington New Zealand"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"E. A.","family":"Mitchell","sequence":"additional","affiliation":[{"name":"Department of Paediatrics University of Auckland Auckland New Zealand"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C.","family":"Barthow","sequence":"additional","affiliation":[{"name":"Wellington Asthma Research Group Wellington School of Medicine and Health Sciences University of Otago Wellington New Zealand"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"P.","family":"Fitzharris","sequence":"additional","affiliation":[{"name":"Immunology Department Auckland Hospital Auckland New Zealand"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"G.","family":"Purdie","sequence":"additional","affiliation":[{"name":"Dean's Department Wellington School of Medicine and Health Sciences University of Otago Wellington New Zealand"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"R.","family":"Siebers","sequence":"additional","affiliation":[{"name":"Wellington Asthma Research Group Wellington School of Medicine and Health Sciences University of Otago Wellington New Zealand"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"P. N.","family":"Black","sequence":"additional","affiliation":[{"name":"Department of Pharmacology & Clinical Pharmacology University of Auckland Auckland New Zealand"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J.","family":"Crane","sequence":"additional","affiliation":[{"name":"Wellington Asthma Research Group Wellington School of Medicine and Health Sciences University of Otago Wellington New Zealand"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2013,8,20]]},"reference":[{"key":"e_1_2_7_2_1","volume-title":"The prolongation of life: optimistic studies","author":"Metchnikoff E","year":"1908"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.299.6710.1259"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2008.07.011"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2222.2012.03975.x"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1399-3038.2010.01079.x"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1398-9995.2010.02507.x"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1017\/S0954422411000102"},{"key":"e_1_2_7_9_1","first-page":"CD006475","article-title":"Probiotics in infants for prevention of allergic disease and food hypersensitivity (Review)","volume":"17","author":"Osborn D","year":"2007","journal-title":"Cochr Database of Syst Rev"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1159\/000334150"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2133.1994.tb08530.x"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.1159\/000247298"},{"key":"e_1_2_7_13_1","unstructured":"ASCIA skin prick testing working party.Skin prick testing for the diagnosis of allergic disease. 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