{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,23]],"date-time":"2026-08-23T15:51:04Z","timestamp":1787500264585,"version":"build-2736575974"},"reference-count":28,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2013,9,16]],"date-time":"2013-09-16T00:00:00Z","timestamp":1379289600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Clin Experimental Allergy"],"published-print":{"date-parts":[[2013,10]]},"abstract":"<jats:title>Summary<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Little is known about time trend of prevalence of asthma and the association between the changing prevalence and allergen sensitization in Chinese children.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>To determine the changes in prevalence of asthma and allergen sensitization in schoolchildren over a period of 15\u00a0years.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      A total of 6928 schoolchildren aged 13\u201314\u00a0years in 2009 were recruited for the study using the Phase\n                      <jats:styled-content style=\"fixed-case\">III<\/jats:styled-content>\n                      Protocol of the International Study of Asthma and Allergic disease in Childhood (\n                      <jats:styled-content style=\"fixed-case\">ISAAC<\/jats:styled-content>\n                      ) and 2531 of them underwent skin prick test for seven common aeroallergens. The results were compared with those obtained in the Phase I (1994\/95) and\n                      <jats:styled-content style=\"fixed-case\">III<\/jats:styled-content>\n                      (2001\/02)\n                      <jats:styled-content style=\"fixed-case\">ISAAC<\/jats:styled-content>\n                      studies.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      The prevalence of asthma ever and current wheeze increased from 3.9% and 3.4% in 1994, to 4.6% and 4.8% in 2001 (\n                      <jats:italic>P<\/jats:italic>\n                      &lt;0.001), and to 6.9% and 6.1% in 2009 (\n                      <jats:italic>P\u00a0<\/jats:italic>\n                      \u2264\u00a00.008). The prevalence of higher degree of skin response to house dust mites (\n                      <jats:styled-content style=\"fixed-case\">HDM<\/jats:styled-content>\n                      s) and cat, and atopic index increased significantly in all children in 2010 when compared with those in 2002 (\n                      <jats:italic>P<\/jats:italic>\n                      &lt;0.001). Prevalence of wheeze remained unchanged in subjects without sensitization to any tested allergen including\n                      <jats:styled-content style=\"fixed-case\">HDM<\/jats:styled-content>\n                      s (\n                      <jats:italic>P\u00a0<\/jats:italic>\n                      &gt;\u00a00.05). Sensitization to\n                      <jats:styled-content style=\"fixed-case\">HDM<\/jats:styled-content>\n                      s, especially\n                      <jats:italic>Dermatophagoides Pteronyssinus<\/jats:italic>\n                      was associated with increase in prevalence of wheeze.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>\n                      The prevalence of wheeze and sensitization to common aeroallergens in secondary schoolchildren in Guangzhou China has increased significantly since 1994. Sensitization to\n                      <jats:styled-content style=\"fixed-case\">HDM<\/jats:styled-content>\n                      s is an important risk factor associated with the increase in prevalence of wheeze in this group of population in Guangzhou city.\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/cea.12157","type":"journal-article","created":{"date-parts":[[2013,6,18]],"date-time":"2013-06-18T10:50:15Z","timestamp":1371552615000},"page":"1171-1179","source":"Crossref","is-referenced-by-count":59,"title":["House dust mite sensitization is the main risk factor for the increase in prevalence of wheeze in 13\u2010 to 14\u2010year\u2010old schoolchildren in Guangzhou city, China"],"prefix":"10.1111","volume":"43","author":[{"given":"J.","family":"Li","sequence":"first","affiliation":[{"name":"State Key Laboratory of Respiratory Disease The First Affiliated Hospital Guangzhou Medical College Guangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"H.","family":"Wang","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Respiratory Disease The First Affiliated Hospital Guangzhou Medical College Guangzhou China"},{"name":"Department of Medicine Firestone Institute for Respiratory Health St. Joseph's Healthcare McMaster University Hamilton ON Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Y.","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine Guangdong Pharmaceutical University Guangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J.","family":"Zheng","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Respiratory Disease The First Affiliated Hospital Guangzhou Medical College Guangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"G. 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K.","family":"Wong","sequence":"additional","affiliation":[{"name":"Department of Paediatrics Prince of Wales Hospital The Chinese University of Hong Kong Hong Kong China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"N.","family":"Zhong","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Respiratory Disease The First Affiliated Hospital Guangzhou Medical College Guangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2013,9,16]]},"reference":[{"key":"e_1_2_8_2_1","volume-title":"Phase Three manual of the International Study of Asthma and Allergies in Childhood (ISAAC)","author":"ISAAC Steering Committee","year":"2000"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(97)07302-9"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1399-3038.2006.00504.x"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1399-3038.2010.01008.x"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1651-2227.2006.00145.x"},{"key":"e_1_2_8_7_1","first-page":"1014","article-title":"Time trends in the prevalence of asthma and allergic diseases over 7\u00a0years among adolescents in Guangzhou city","volume":"86","author":"Wang HY","year":"2006","journal-title":"Zhonghua yi xue za zhi"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(08)61447-6"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2222.2006.02489.x"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa022363"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(06)69286-6"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1398-9995.2009.01967.x"},{"key":"e_1_2_8_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.imlet.2004.01.016"},{"key":"e_1_2_8_14_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2222.1998.028s5052.x"},{"key":"e_1_2_8_15_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2222.1997.tb00742.x"},{"key":"e_1_2_8_16_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2222.1987.tb02017.x"},{"key":"e_1_2_8_17_1","doi-asserted-by":"publisher","DOI":"10.1034\/j.1398-9995.2001.00834.x"},{"key":"e_1_2_8_18_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2222.2004.02084.x"},{"key":"e_1_2_8_19_1","doi-asserted-by":"publisher","DOI":"10.1136\/adc.2003.031112"},{"key":"e_1_2_8_20_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2222.2004.02064.x"},{"key":"e_1_2_8_21_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.rmed.2005.12.007"},{"key":"e_1_2_8_22_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1398-9995.2009.02244.x"},{"key":"e_1_2_8_23_1","doi-asserted-by":"publisher","DOI":"10.1093\/ije\/31.6.1098"},{"key":"e_1_2_8_24_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1398-9995.2010.02465.x"},{"key":"e_1_2_8_25_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0668.2009.00611.x"},{"key":"e_1_2_8_26_1","first-page":"14","volume-title":"China daily\/business","author":"Andrews M","year":"2011"},{"key":"e_1_2_8_27_1","doi-asserted-by":"publisher","DOI":"10.1183\/09031936.97.10020354"},{"key":"e_1_2_8_28_1","doi-asserted-by":"publisher","DOI":"10.1183\/09031936.02.002319.02"},{"key":"e_1_2_8_29_1","doi-asserted-by":"publisher","DOI":"10.1186\/1465-9921-12-95"}],"container-title":["Clinical &amp; Experimental Allergy"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fcea.12157","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/cea.12157","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,3]],"date-time":"2023-10-03T10:46:51Z","timestamp":1696330011000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/cea.12157"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2013,9,16]]},"references-count":28,"journal-issue":{"issue":"10","published-print":{"date-parts":[[2013,10]]}},"alternative-id":["10.1111\/cea.12157"],"URL":"https:\/\/doi.org\/10.1111\/cea.12157","archive":["Portico"],"relation":{},"ISSN":["0954-7894","1365-2222"],"issn-type":[{"value":"0954-7894","type":"print"},{"value":"1365-2222","type":"electronic"}],"subject":[],"published":{"date-parts":[[2013,9,16]]}}}