{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T08:13:31Z","timestamp":1791274411204,"version":"4.1.0"},"reference-count":49,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2013,9,16]],"date-time":"2013-09-16T00:00:00Z","timestamp":1379289600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Clin Experimental Allergy"],"published-print":{"date-parts":[[2013,10]]},"abstract":"<jats:title>Summary<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Atopic dermatitis (<jats:styled-content style=\"fixed-case\">AD<\/jats:styled-content>) is common in children; however, persistence of <jats:styled-content style=\"fixed-case\">AD<\/jats:styled-content> with or without asthma is less common. Longitudinal studies remain limited in their ability to characterize how IgE antibody responses evolve in <jats:styled-content style=\"fixed-case\">AD<\/jats:styled-content>, and their relationship with asthma.<\/jats:p><\/jats:sec><jats:sec><jats:title>Objective<\/jats:title><jats:p>To use a cross\u2010sectional study design of children with active <jats:styled-content style=\"fixed-case\">AD<\/jats:styled-content> to analyse age\u2010related differences in IgE antibodies and relation to wheeze.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>IgE antibodies to food and inhalant allergens were measured in children with active <jats:styled-content style=\"fixed-case\">AD<\/jats:styled-content> (5\u00a0months to 15\u00a0years of age, <jats:italic>n<\/jats:italic>\u00a0=\u00a066), with and without history of wheeze.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Whereas IgE antibodies to foods persisted at a similar prevalence and titre throughout childhood, IgE antibodies to all aeroallergens rose sharply into adolescence. From birth, the chance of sensitization for any aeroallergen increased for each 12\u2010month increment in age (<jats:styled-content style=\"fixed-case\">OR<\/jats:styled-content>\u00a0\u2265\u00a01.21, <jats:italic>P<\/jats:italic>\u00a0&lt;\u00a00.01), with the largest effect observed for dust mite (<jats:styled-content style=\"fixed-case\">OR<\/jats:styled-content>\u00a0=\u00a01.56, <jats:italic>P<\/jats:italic>\u00a0&lt;\u00a00.001). A steeper age\u2010related rise in IgE antibody titre to dust mite, but no other allergen was associated with more severe disease. Despite this, sensitization to cat was more strongly associated with wheeze (<jats:styled-content style=\"fixed-case\">OR<\/jats:styled-content>\u00a0=\u00a04.5, <jats:italic>P<\/jats:italic>\u00a0&lt;\u00a00.01), and linked to Fel d 1 and Fel d 4, but not Fel d 2. Comparison of cat allergic children with <jats:styled-content style=\"fixed-case\">AD<\/jats:styled-content> to those without, revealed higher IgE levels to Fel d 2 and Fel d 4 (<jats:italic>P<\/jats:italic>\u00a0&lt;\u00a00.05), but not Fel d 1.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions and Clinical Relevance<\/jats:title><jats:p>Differences in sensitization to cat and dust mite among young children with <jats:styled-content style=\"fixed-case\">AD<\/jats:styled-content> may aid in identifying those at increased risk for disease progression and development of asthma. Early sensitization to cat and risk for wheeze among children with <jats:styled-content style=\"fixed-case\">AD<\/jats:styled-content> may be linked to an increased risk for sensitization to a broader spectrum of allergen components from early life. Collectively, our findings argue for early intervention strategies designed to mitigate skin inflammation in children with <jats:styled-content style=\"fixed-case\">AD<\/jats:styled-content>.<\/jats:p><\/jats:sec>","DOI":"10.1111\/cea.12169","type":"journal-article","created":{"date-parts":[[2013,7,3]],"date-time":"2013-07-03T20:56:30Z","timestamp":1372884990000},"page":"1160-1170","source":"Crossref","is-referenced-by-count":59,"title":["Sensitization to food and inhalant allergens in relation to age and wheeze among children with atopic dermatitis"],"prefix":"10.1111","volume":"43","author":[{"given":"J. A.","family":"Wisniewski","sequence":"first","affiliation":[{"name":"Asthma and Allergic Diseases Center University of Virginia Health System Charlottesville VA USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"R.","family":"Agrawal","sequence":"additional","affiliation":[{"name":"Asthma and Allergic Diseases Center University of Virginia Health System Charlottesville VA USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S.","family":"Minnicozzi","sequence":"additional","affiliation":[{"name":"Asthma and Allergic Diseases Center University of Virginia Health System Charlottesville VA USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"W.","family":"Xin","sequence":"additional","affiliation":[{"name":"Department of Public Health Sciences University of Virginia Health System Charlottesville VA USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J.","family":"Patrie","sequence":"additional","affiliation":[{"name":"Department of Public Health Sciences University of Virginia Health System Charlottesville VA USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"P. W.","family":"Heymann","sequence":"additional","affiliation":[{"name":"Asthma and Allergic Diseases Center University of Virginia Health System Charlottesville VA USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"L.","family":"Workman","sequence":"additional","affiliation":[{"name":"Asthma and Allergic Diseases Center University of Virginia Health System Charlottesville VA USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"T. A.","family":"Platts\u2010Mills","sequence":"additional","affiliation":[{"name":"Asthma and Allergic Diseases Center University of Virginia Health System Charlottesville VA USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"T. 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