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However, the ability of <jats:styled-content style=\"fixed-case\">HRV<\/jats:styled-content> infections to trigger exacerbations, and the link between allergic status and <jats:styled-content style=\"fixed-case\">HRV<\/jats:styled-content> responsiveness, remains incompletely understood. Whilst the receptors on human airway cells that detect and are utilized by most HRV group A and B, but not C serotypes are known, how endosomal pattern recognition receptors (<jats:styled-content style=\"fixed-case\">PRR<\/jats:styled-content>s) detect <jats:styled-content style=\"fixed-case\">HRV<\/jats:styled-content> replication products that are generated within the cytoplasm remains somewhat of an enigma. In this article, we explore a role for autophagy, a cellular homeostatic process that allows the cell to encapsulate its own cytosolic constituents, as the crucial mechanism controlling this process and regulating the innate immune response of airway epithelial cells to viral infection. We will also briefly describe some of the recent insights into the immune responses of the airway to <jats:styled-content style=\"fixed-case\">HRV<\/jats:styled-content>, focusing on neutrophilic inflammation that is a potentially unwanted feature of the acute response to viral infection, and the roles of <jats:styled-content style=\"fixed-case\">IL<\/jats:styled-content>\u20101 and Pellinos in the regulation of responses to <jats:styled-content style=\"fixed-case\">HRV<\/jats:styled-content>.<\/jats:p>","DOI":"10.1111\/cea.12182","type":"journal-article","created":{"date-parts":[[2013,7,31]],"date-time":"2013-07-31T08:48:26Z","timestamp":1375260506000},"page":"20-28","source":"Crossref","is-referenced-by-count":11,"title":["Rhinoviral infection and asthma: the detection and management of rhinoviruses by airway epithelial cells"],"prefix":"10.1111","volume":"44","author":[{"given":"L. 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