{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T09:47:26Z","timestamp":1791280046404,"version":"4.1.0"},"reference-count":32,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2014,1,22]],"date-time":"2014-01-22T00:00:00Z","timestamp":1390348800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Clin Experimental Allergy"],"published-print":{"date-parts":[[2014,2]]},"abstract":"<jats:title>Summary<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Cross\u2010sectional and longitudinal reports show that obese adults have more asthma than non\u2010obese adults. A proposed mechanism is via effects of adipokines (leptin and adiponectin) on the immune system.<\/jats:p><\/jats:sec><jats:sec><jats:title>Objective<\/jats:title><jats:p>We wished to measure the associations of asthma and other atopic diseases with serum adipokine levels and to find whether the associations with asthma were strong enough to rule out the possibility that they are secondary to the association of fatness measures with asthma.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>The <jats:styled-content style=\"fixed-case\">G<\/jats:styled-content>lobal <jats:styled-content style=\"fixed-case\">A<\/jats:styled-content>sthma and <jats:styled-content style=\"fixed-case\">A<\/jats:styled-content>llergy <jats:styled-content style=\"fixed-case\">N<\/jats:styled-content>etwork of <jats:styled-content style=\"fixed-case\">E<\/jats:styled-content>xcellence (<jats:styled-content style=\"fixed-case\">GA<\/jats:styled-content><jats:sup>2<\/jats:sup><jats:styled-content style=\"fixed-case\">LEN<\/jats:styled-content>) clinical follow\u2010up survey is a clinical survey, embedded in a larger multi\u2010centre cross\u2010sectional postal survey, involving, with a case\/control design, enrichment of the sample with subjects with asthma and chronic rhinosinusitis (<jats:styled-content style=\"fixed-case\">CRS<\/jats:styled-content>). We recorded serum leptin or adiponectin in 845 men and 1110 women in 15 centres and also anthropometric measures of fatness including body mass index and waist\/hip ratio, current asthma, and specific skin prick and <jats:styled-content style=\"fixed-case\">I<\/jats:styled-content>g<jats:styled-content style=\"fixed-case\">E<\/jats:styled-content> sensitisation. We used inverse sampling\u2010probability\u2010weighted rank and regression statistics to measure population associations of disease outcomes with adipokines in males and females, adjusting for confounders (area, age, smoking history, and number of elder siblings) and also mutually adjusting associations with adipokines and fatness measures.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>One thousand nine hundred and fifty\u2010five subjects aged 16\u201377\u00a0years had information on leptin or adiponectin levels. Leptin and leptin\/adiponectin ratio were positively associated with the level of asthma, especially in females (<jats:styled-content style=\"fixed-case\">S<\/jats:styled-content>omers\u2019 <jats:italic><jats:styled-content style=\"fixed-case\">D<\/jats:styled-content><\/jats:italic> of leptin by asthma score, 0.20; 95% <jats:styled-content style=\"fixed-case\">CI<\/jats:styled-content>, 0.08\u20130.30; <jats:italic>P<\/jats:italic>\u00a0=\u00a00.00079). These associations were attenuated after adjusting for confounders and became non\u2010significant after additionally adjusting for fatness measures and multiple comparisons.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions and Clinical Relevance<\/jats:title><jats:p>Asthma levels are positively associated with serum leptin. However, we cannot rule out the possibility that this association is secondary to associations of both with fatness measures.<\/jats:p><\/jats:sec>","DOI":"10.1111\/cea.12221","type":"journal-article","created":{"date-parts":[[2013,10,21]],"date-time":"2013-10-21T13:32:47Z","timestamp":1382362367000},"page":"250-260","source":"Crossref","is-referenced-by-count":38,"title":["The association of asthma, nasal allergies, and positive skin prick tests with obesity, leptin, and adiponectin"],"prefix":"10.1111","volume":"44","author":[{"given":"R. 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M.","family":"Toskala","sequence":"additional","affiliation":[{"name":"Skin and Allergy Hospital Helsinki University Helsinki Finland"},{"name":"Department of ORL\u2010HNS Temple University Philadelphia PA USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A.","family":"Al\u2010Kalemji","sequence":"additional","affiliation":[{"name":"Odense University Hospital Odense University Odense Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M. L.","family":"Kowalski","sequence":"additional","affiliation":[{"name":"Department of Immunology, Rheumatology and Allergy Medical University of Lodz Lodz Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"B.","family":"Rymarczyk","sequence":"additional","affiliation":[{"name":"Department of Allergology and Clinical Immunology Medical University of Silesia Katowice Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"E. 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M.","family":"van Drunen","sequence":"additional","affiliation":[{"name":"Department of Otorhinolaryngology Academic Medical Center Amsterdam The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C.","family":"Bachert","sequence":"additional","affiliation":[{"name":"University of Ghent Ghent Belgium"},{"name":"Division of Ear, Nose, and Throat Diseases Karolinska Institute CLINTEC Stockholm Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"T.","family":"Wehrend","sequence":"additional","affiliation":[{"name":"Department of Pediatric Pneumonology and Immunology Charit\u00e9\u2010Universit\u00e4tsmedizin Berlin Berlin Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"U.","family":"Kr\u00e4mer","sequence":"additional","affiliation":[{"name":"IUF \u2013 Leibniz Research Institute for Environmental Medicine D\u00fcsseldorf 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