{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,27]],"date-time":"2026-09-27T10:30:24Z","timestamp":1790505024436,"version":"4.1.0"},"reference-count":26,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2014,1,22]],"date-time":"2014-01-22T00:00:00Z","timestamp":1390348800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Clin Experimental Allergy"],"published-print":{"date-parts":[[2014,2]]},"abstract":"<jats:title>Summary<\/jats:title><jats:sec><jats:label\/><jats:p>Anaesthetic hypersensitivity reactions can be <jats:styled-content style=\"fixed-case\">I<\/jats:styled-content>g<jats:styled-content style=\"fixed-case\">E<\/jats:styled-content>\u2010 or not <jats:styled-content style=\"fixed-case\">I<\/jats:styled-content>g<jats:styled-content style=\"fixed-case\">E<\/jats:styled-content>\u2010mediated and are a challenge to find the causal agent. Histamine and tryptase determination are classically considered useful in the diagnosis of these reactions. The aim of our study was to assess the diagnostic usefulness of plasma histamine and different cut\u2010off points of serum tryptase.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Patients suffering a reaction suggestive of hypersensitivity during general anaesthesia in <jats:styled-content style=\"fixed-case\">C<\/jats:styled-content>l\u00ednica <jats:styled-content style=\"fixed-case\">U<\/jats:styled-content>niversidad de <jats:styled-content style=\"fixed-case\">N<\/jats:styled-content>avarra (2008\u20132012) were included. Serum tryptase and plasma histamine were measured at the time of the reaction and 2\u00a0h later. Baseline tryptase was also determined. Four to eight weeks after the reaction an allergological study was performed to all the drugs or products involved in the reaction.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Sixty\u2010five patients suffered an immediate hypersensitivity reaction during the period of the study. Thirty\u2010seven patients (20 male) with median age 48\u00a0years (12\u201379) were included because they completed allergological study, and histamine and tryptase were correctly obtained. Elevated plasma histamine was observed in 34 cases (92%). Tryptase exceeded twice the basal values in 10 patients (31%). Using different cut\u2010off points of tryptase, the number of patients with elevated tryptase would be 15 patients (41%) for a cut\u2010off point of 5\u00a0\u03bcg\/L; 12 patients (32%) for a cut\u2010off point of 8.23\u00a0\u03bcg\/L; nine patients (24%) for 10.5\u00a0\u03bcg\/L; and eight patients (22%) for 11.4\u00a0\u03bcg\/L. The median tryptase level for the <jats:styled-content style=\"fixed-case\">I<\/jats:styled-content>g<jats:styled-content style=\"fixed-case\">E<\/jats:styled-content>\u2010mediated reactions was 9.0\u00a0\u03bcg\/L (2\u201370\u00a0\u03bcg\/L) and 4.0\u00a0\u03bcg\/L (3\u201313\u00a0\u03bcg\/L) in non\u2010<jats:styled-content style=\"fixed-case\">I<\/jats:styled-content>g<jats:styled-content style=\"fixed-case\">E<\/jats:styled-content>\u2010mediated reactions (<jats:italic>P<\/jats:italic>\u00a0&lt;\u00a00.01). Median tryptase levels were higher in more severe reactions (grade 2 or 3) in comparison with grade 1. The best ratio for serum\u2010tryptase\u2010during\u2010reaction\/basal\u2010serum\u2010tryptase to discriminate between <jats:styled-content style=\"fixed-case\">I<\/jats:styled-content>g<jats:styled-content style=\"fixed-case\">E<\/jats:styled-content> and non\u2010<jats:styled-content style=\"fixed-case\">I<\/jats:styled-content>g<jats:styled-content style=\"fixed-case\">E<\/jats:styled-content> reactions was 2.0.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>The best criterion for discriminating <jats:styled-content style=\"fixed-case\">I<\/jats:styled-content>g<jats:styled-content style=\"fixed-case\">E<\/jats:styled-content>\u2010 and non <jats:styled-content style=\"fixed-case\">I<\/jats:styled-content>g<jats:styled-content style=\"fixed-case\">E<\/jats:styled-content>\u2010mediated hypersensitivity reactions in anaesthesia was a tryptase value exceeding twice the basal one.<\/jats:p><\/jats:sec>","DOI":"10.1111\/cea.12237","type":"journal-article","created":{"date-parts":[[2013,11,18]],"date-time":"2013-11-18T06:15:36Z","timestamp":1384755336000},"page":"270-277","source":"Crossref","is-referenced-by-count":37,"title":["The usefulness of plasma histamine and different tryptase cut\u2010off points in the diagnosis of peranaesthetic hypersensitivity reactions"],"prefix":"10.1111","volume":"44","author":[{"given":"F.","family":"Berroa","sequence":"first","affiliation":[{"name":"Departamento de Alergolog\u00eda e Inmunolog\u00eda Cl\u00ednica Cl\u00ednica Universidad de Navarra Pamplona Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A.","family":"Lafuente","sequence":"additional","affiliation":[{"name":"Departamento de Anestesiolog\u00eda Cl\u00ednica Universidad de Navarra Pamplona Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"G.","family":"Javaloyes","sequence":"additional","affiliation":[{"name":"Departamento de Alergolog\u00eda e Inmunolog\u00eda Cl\u00ednica Cl\u00ednica Universidad de Navarra Pamplona Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M.","family":"Ferrer","sequence":"additional","affiliation":[{"name":"Departamento de Alergolog\u00eda e Inmunolog\u00eda Cl\u00ednica Cl\u00ednica Universidad de Navarra Pamplona Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"R.","family":"Moncada","sequence":"additional","affiliation":[{"name":"Departamento de Anestesiolog\u00eda Cl\u00ednica Universidad de Navarra Pamplona Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M. 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