{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,23]],"date-time":"2026-09-23T13:18:22Z","timestamp":1790169502621,"version":"4.1.0"},"reference-count":24,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2014,2,22]],"date-time":"2014-02-22T00:00:00Z","timestamp":1393027200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/3.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Clin Experimental Allergy"],"published-print":{"date-parts":[[2014,3]]},"abstract":"Summary<\/jats:title>Background<\/jats:title>Within a large prospective study, the G<\/jats:styled-content>lobal A<\/jats:styled-content>sthma and A<\/jats:styled-content>llergy E<\/jats:styled-content>uropean N<\/jats:styled-content>etwork (GA<\/jats:styled-content>2<\/jats:sup>LEN<\/jats:styled-content>) has collected skin prick test (SPT<\/jats:styled-content>) data throughout E<\/jats:styled-content>urope to make recommendations for SPT in clinical settings.<\/jats:p><\/jats:sec>Objective<\/jats:title>To improve clinical interpretation of SPT<\/jats:styled-content> results for inhalant allergens by providing quantitative decision points.<\/jats:p><\/jats:sec>Methods<\/jats:title>The GA<\/jats:styled-content>2<\/jats:sup>LEN SPT<\/jats:styled-content> study with 3068 valid data sets was used to investigate the relationship between SPT results and patient\u2010reported clinical relevance for each of the 18 inhalant allergens as well as SPT wheal size and physician\u2010diagnosed allergy (rhinitis, asthma, atopic dermatitis, food allergy). The effects of age, gender, and geographical area on SPT results were assessed. For each allergen, the wheal size in mm with an 80% positive predictive value (PPV) for being clinically relevant was calculated.<\/jats:p><\/jats:sec>Results<\/jats:title>Depending on the allergen, from 40% (blatella) to 87\u201389% (grass, mites) of the positive SPT reactions (wheal size\u00a0\u2265\u00a03\u00a0mm) were associated with patient\u2010reported clinical symptoms when exposed to the respective allergen. The risk of allergic symptoms increased significantly with larger wheal sizes for 17 of the 18 allergens tested. Children with positive SPT reactions had a smaller risk of sensitizations being clinically relevant compared with adults. The 80% PPV varied from 3 to 10\u00a0mm depending on the allergen.<\/jats:p><\/jats:sec>Conclusion<\/jats:title>These \u2018reading keys\u2019 for 18 inhalant allergens can help interpret SPT results with respect to their clinical significance. A SPT<\/jats:styled-content> form with the standard allergens including mm decision points for each allergen is offered for clinical use.<\/jats:p><\/jats:sec>","DOI":"10.1111\/cea.12240","type":"journal-article","created":{"date-parts":[[2013,11,27]],"date-time":"2013-11-27T15:32:49Z","timestamp":1385566369000},"page":"407-416","source":"Crossref","is-referenced-by-count":67,"title":["Clinical relevance is associated with allergen\u2010specific wheal size in skin prick testing"],"prefix":"10.1111","volume":"44","author":[{"given":"T.","family":"Haahtela","sequence":"first","affiliation":[{"name":"Skin and Allergy Hospital Helsinki University Hospital Helsinki Finland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"G. 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