{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2023,10,18]],"date-time":"2023-10-18T23:28:04Z","timestamp":1697671684856},"reference-count":33,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2014,2,22]],"date-time":"2014-02-22T00:00:00Z","timestamp":1393027200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Clin Experimental Allergy"],"published-print":{"date-parts":[[2014,3]]},"abstract":"<jats:title>Summary<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Almost a quarter of the world population suffers from <jats:styled-content style=\"fixed-case\">I<\/jats:styled-content>g<jats:styled-content style=\"fixed-case\">E<\/jats:styled-content>\u2010mediated allergies. <jats:styled-content style=\"fixed-case\">T<\/jats:styled-content> cells and <jats:styled-content style=\"fixed-case\">I<\/jats:styled-content>g<jats:styled-content style=\"fixed-case\">G<\/jats:styled-content>\u2010producing <jats:styled-content style=\"fixed-case\">B<\/jats:styled-content> cells can produce protection, but treatment for disease is laborious with unsatisfactory patient compliance.<\/jats:p><\/jats:sec><jats:sec><jats:title>Objective<\/jats:title><jats:p>We sought to identify whether paediatric allergy vaccines affected later allergen sensitization and onset of disease when used prophylactically.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>A murine model of anaphylaxis was applied. Mice were first immunized with monovalent or multivalent allergy vaccines that also contained aluminium hydroxide and <jats:styled-content style=\"fixed-case\">C<\/jats:styled-content>p<jats:styled-content style=\"fixed-case\">G<\/jats:styled-content> oligodeoxynucleotide as adjuvants. Later, the mice were sensitized by multiple low\u2010dose injections of aluminium\u2010adsorbed allergen. After a dormant period, the mice were challenged systemically with high\u2010dose allergen, and the clinical signs of anaphylaxis were recorded. Throughout the immunization and sensitization periods, blood was collected for serological testing.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Immunization with allergy vaccines produced antigen\u2010specific protection against sensitization as measured by systemic anaphylaxis in mice. The long\u2010term effect was observed both after juvenile (5\u20136\u00a0weeks) and neonatal (7\u00a0days) vaccination. Monovalent and pentavalent vaccines were protective to a similar level. Protection was associated with increased secretion of <jats:styled-content style=\"fixed-case\">I<\/jats:styled-content>g<jats:styled-content style=\"fixed-case\">G<\/jats:styled-content>2a and production of <jats:styled-content style=\"fixed-case\">IFN<\/jats:styled-content>\u2010\u03b3. Protection could also be transferred to sensitized mice via serum or via <jats:styled-content style=\"fixed-case\">CD<\/jats:styled-content>25\u2010positive <jats:styled-content style=\"fixed-case\">CD<\/jats:styled-content>4 <jats:styled-content style=\"fixed-case\">T<\/jats:styled-content> cells.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion and clinical relevance<\/jats:title><jats:p>Prophylactic and multivalent allergy vaccines in juvenile and neonatal mice protected against later sensitization and anaphylaxis. Such treatment may provide a rational measure for future management of allergen\u2010related diseases and their strong socio\u2010economic impact on daily life.<\/jats:p><\/jats:sec>","DOI":"10.1111\/cea.12245","type":"journal-article","created":{"date-parts":[[2013,11,29]],"date-time":"2013-11-29T04:57:08Z","timestamp":1385701028000},"page":"429-437","source":"Crossref","is-referenced-by-count":2,"title":["Multivalent paediatric allergy vaccines protect against allergic anaphylaxis in mice"],"prefix":"10.1111","volume":"44","author":[{"given":"Y.","family":"Waeckerle\u2010Men","sequence":"first","affiliation":[{"name":"Department of Dermatology University Hospital Zurich Zurich Switzerland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Y.","family":"Liang","sequence":"additional","affiliation":[{"name":"Department of Dermatology University Hospital Zurich Zurich Switzerland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"S.","family":"von Moos","sequence":"additional","affiliation":[{"name":"Department of Dermatology University Hospital Zurich Zurich Switzerland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"T. 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