{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,5]],"date-time":"2025-12-05T12:11:40Z","timestamp":1764936700520},"reference-count":25,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2014,5,24]],"date-time":"2014-05-24T00:00:00Z","timestamp":1400889600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Clin Experimental Allergy"],"published-print":{"date-parts":[[2014,6]]},"abstract":"<jats:title>Summary<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Mouse models of atopic march suggest that systemic, skin\u2010derived thymic stromal lymphopoietin (<jats:styled-content style=\"fixed-case\">TSLP<\/jats:styled-content>) mediates progression from eczema to asthma.<\/jats:p><\/jats:sec><jats:sec><jats:title>Objective<\/jats:title><jats:p>We investigated whether circulating <jats:styled-content style=\"fixed-case\">TSLP<\/jats:styled-content> is associated with eczema, allergic sensitization, or recurrent wheezing in young children.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>A prospective analysis of the relationship between plasma levels of <jats:styled-content style=\"fixed-case\">TSLP<\/jats:styled-content> to allergic sensitization and recurrent wheezing was conducted in the birth cohort from the Urban Environment and Childhood Asthma (<jats:styled-content style=\"fixed-case\">URECA<\/jats:styled-content>) study. Plasma <jats:styled-content style=\"fixed-case\">TSLP<\/jats:styled-content> levels were measured at 1, 2, and 3\u00a0years of age and analysed for correlation with clinical parameters in each of the three years. Only those children with consecutive samples for all three years were included in this analysis.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>We detected <jats:styled-content style=\"fixed-case\">TSLP<\/jats:styled-content> in 33% of 236 children for whom plasma samples were available for all three years. Overall, a consistently significant association was not found between <jats:styled-content style=\"fixed-case\">TSLP<\/jats:styled-content> and eczema or allergic sensitization. With regard to recurrent wheezing, children with detectable <jats:styled-content style=\"fixed-case\">TSLP<\/jats:styled-content> at one year of age were significantly less likely to experience recurrent wheezing by 3\u00a0years compared with those children without detectable <jats:styled-content style=\"fixed-case\">TSLP<\/jats:styled-content>, but this was only seen in children without aeroallergen sensitization at 3\u00a0years (<jats:italic>P<\/jats:italic>\u00a0&lt;\u00a00.01).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions and Clinical Relevance<\/jats:title><jats:p>Contrary to our expectations, circulating <jats:styled-content style=\"fixed-case\">TSLP<\/jats:styled-content> was not significantly associated with eczema, allergen sensitization, or recurrent wheezing during the first three years of life. Early presence of circulating <jats:styled-content style=\"fixed-case\">TSLP<\/jats:styled-content> was significantly associated with reduced incidence of recurrent wheeze in those children not sensitized to aeroallergen. These findings suggest a possible underlying distinction between pathogenesis of developing atopic vs. non\u2010atopic recurrent wheeze.<\/jats:p><\/jats:sec>","DOI":"10.1111\/cea.12270","type":"journal-article","created":{"date-parts":[[2014,1,7]],"date-time":"2014-01-07T14:02:43Z","timestamp":1389103363000},"page":"851-857","source":"Crossref","is-referenced-by-count":13,"title":["Circulating <scp>TSLP<\/scp> associates with decreased wheezing in non\u2010atopic preschool children: data from the <scp>URECA<\/scp> birth cohort"],"prefix":"10.1111","volume":"44","author":[{"given":"S.","family":"Demehri","sequence":"first","affiliation":[{"name":"Washington University School of Medicine St. Louis MO USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"L. J.","family":"Yockey","sequence":"additional","affiliation":[{"name":"Washington University School of Medicine St. Louis MO USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"C. M.","family":"Visness","sequence":"additional","affiliation":[{"name":"Rho Federal Systems Division, Inc. Chapel Hill NC USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"K. F.","family":"Jaffee","sequence":"additional","affiliation":[{"name":"Rho Federal Systems Division, Inc. Chapel Hill NC USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A.","family":"Turkoz","sequence":"additional","affiliation":[{"name":"Washington University School of Medicine St. Louis MO USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"R. A.","family":"Wood","sequence":"additional","affiliation":[{"name":"Johns Hopkins University School of Medicine Baltimore MD USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"G. T.","family":"O'Connor","sequence":"additional","affiliation":[{"name":"Boston University School of Medicine Boston MA USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M.","family":"Kattan","sequence":"additional","affiliation":[{"name":"Columbia University School of Medicine New York NY USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J. E.","family":"Gern","sequence":"additional","affiliation":[{"name":"University of Wisconsin School of Medicine and Public Health Madison WI USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"P. J.","family":"Gergen","sequence":"additional","affiliation":[{"name":"Division of Allergy, Immunology, and Transplantation National Institutes of Health Bethesda MD USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M.","family":"Holtzman","sequence":"additional","affiliation":[{"name":"Washington University School of Medicine St. Louis MO USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"G.","family":"Bloomberg","sequence":"additional","affiliation":[{"name":"Washington University School of Medicine St. Louis MO USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"R.","family":"Kopan","sequence":"additional","affiliation":[{"name":"Washington University School of Medicine St. Louis MO USA"},{"name":"Division of Developmental Biology Cincinnati Children's Hospital Medical Center University of Cincinnati College of Medicine Cincinnati OH USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2014,5,24]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pbio.0060123"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0009258"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1084\/jem.20082242"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1172\/JCI28521"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0801532105"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1084\/jem.20051745"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1038\/ni805"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1084\/jem.20041503"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1038\/ni.1852"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.182.3.1641"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.1038\/ni1247"},{"key":"e_1_2_7_13_1","doi-asserted-by":"publisher","DOI":"10.1165\/rcmb.2008-0041OC"},{"key":"e_1_2_7_14_1","doi-asserted-by":"publisher","DOI":"10.1165\/rcmb.2009-0418OC"},{"key":"e_1_2_7_15_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1398-9995.2010.02415.x"},{"key":"e_1_2_7_16_1","doi-asserted-by":"publisher","DOI":"10.1093\/hmg\/ddh094"},{"key":"e_1_2_7_17_1","doi-asserted-by":"publisher","DOI":"10.1186\/1471-2350-10-59"},{"key":"e_1_2_7_18_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0812668106"},{"key":"e_1_2_7_19_1","doi-asserted-by":"publisher","DOI":"10.1038\/jid.2008.232"},{"key":"e_1_2_7_20_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0604575103"},{"key":"e_1_2_7_21_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pbio"},{"key":"e_1_2_7_22_1","doi-asserted-by":"publisher","DOI":"10.1186\/1471-2466-9-17"},{"key":"e_1_2_7_23_1","doi-asserted-by":"publisher","DOI":"10.1034\/j.1600-0625.2001.100102.x"},{"key":"e_1_2_7_24_1","doi-asserted-by":"publisher","DOI":"10.1038\/mi.2012.14"},{"key":"e_1_2_7_25_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1399-3038.2009.00919.x"},{"key":"e_1_2_7_26_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2010.06.032"}],"container-title":["Clinical &amp; Experimental Allergy"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fcea.12270","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/cea.12270","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,3]],"date-time":"2023-10-03T04:05:01Z","timestamp":1696305901000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/cea.12270"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2014,5,24]]},"references-count":25,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2014,6]]}},"alternative-id":["10.1111\/cea.12270"],"URL":"https:\/\/doi.org\/10.1111\/cea.12270","archive":["Portico"],"relation":{},"ISSN":["0954-7894","1365-2222"],"issn-type":[{"value":"0954-7894","type":"print"},{"value":"1365-2222","type":"electronic"}],"subject":[],"published":{"date-parts":[[2014,5,24]]}}}