{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,5]],"date-time":"2026-03-05T23:06:36Z","timestamp":1772751996403,"version":"3.50.1"},"reference-count":49,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2014,5,24]],"date-time":"2014-05-24T00:00:00Z","timestamp":1400889600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Clin Experimental Allergy"],"published-print":{"date-parts":[[2014,6]]},"abstract":"<jats:title>Summary<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Exercise\u2010induced bronchospasm (<jats:styled-content style=\"fixed-case\">EIB<\/jats:styled-content>) is frequent among asthmatic children. However, opinions differ on the relation between <jats:styled-content style=\"fixed-case\">EIB<\/jats:styled-content> and rhinitis in the absence of asthma.<\/jats:p><\/jats:sec><jats:sec><jats:title>Objectives<\/jats:title><jats:p>We assessed the relationship between <jats:styled-content style=\"fixed-case\">EIB<\/jats:styled-content> and various phenotypes of rhinitis according to asthmatic status at the general population level in the Six Cities Study.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Of 7781 schoolchildren with a mean age of 10\u00a0years underwent an <jats:styled-content style=\"fixed-case\">EIB<\/jats:styled-content> test and skin prick test to assess allergic sensitization. Their parents completed a standardized questionnaire recording asthma\u2010like symptoms and past\u2010year rhinoconjunctivitis, ever hay fever (EHF), and a score for allergic rhinitis (<jats:styled-content style=\"fixed-case\">SFAR<\/jats:styled-content>) \u22657 as a marker of \u2018past\u2010year allergic rhinitis\u2019. Exercise\u2010induced bronchospasm was defined as a fall in peak expiratory flow rate \u226515% after exercise.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Of the 6813 schoolchildren retained for analysis, 227 (3.33%) experienced <jats:styled-content style=\"fixed-case\">EIB<\/jats:styled-content> after exercise. Odds ratios [95% confidence intervals] between <jats:styled-content style=\"fixed-case\">EIB<\/jats:styled-content> and allergic rhinitis phenotypes in the absence of asthma were 1.56 [0.92\u20132.63] for EHF, 1.97 [1.16\u20133.35] for past\u2010year rhinoconjunctivitis, and 1.84 [1.16\u20132.91] for a <jats:styled-content style=\"fixed-case\">SFAR<\/jats:styled-content> \u22657. Results were unchanged after adjustment for confounders. Multiple correspondence analysis showed that <jats:styled-content style=\"fixed-case\">EIB<\/jats:styled-content>, although related to asthma, constitutes a separate entity. Exercise\u2010induced bronchospasm was not significantly related to familial history of asthma.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>In our large population\u2010based sample of children, different phenotypes of atopic rhinitis were associated with <jats:styled-content style=\"fixed-case\">EIB<\/jats:styled-content>, independently of asthma. Exercise\u2010induced bronchospasm, although related to asthma, seems to constitute a separate entity.<\/jats:p><\/jats:sec><jats:sec><jats:title>Clinical relevance<\/jats:title><jats:p>In this large (6813) sample of 10\u2010year children drawn from the general population, EIB is associated with rhinitis phenotypes in the absence of asthma. Furthermore, it constitutes an entity independent from asthma and is not related to a familial history of asthma. Thus, investigating these symptoms could be important in this disease, as a specific nasal treatment might improve <jats:styled-content style=\"fixed-case\">EIB<\/jats:styled-content> in these children.<\/jats:p><\/jats:sec>","DOI":"10.1111\/cea.12310","type":"journal-article","created":{"date-parts":[[2014,3,25]],"date-time":"2014-03-25T16:54:52Z","timestamp":1395766492000},"page":"858-866","source":"Crossref","is-referenced-by-count":16,"title":["Exercise\u2010induced bronchospasm related to different phenotypes of rhinitis without asthma in primary schoolchildren: the French Six Cities Study"],"prefix":"10.1111","volume":"44","author":[{"given":"D.","family":"Caillaud","sequence":"first","affiliation":[{"name":"Service de Pneumologie CHU Gabriel Montpied Universit\u00e9 d'Auvergne Clermont\u2010Ferrand France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"K.","family":"Horo","sequence":"additional","affiliation":[{"name":"Service de Pneumologie CHU Gabriel Montpied Universit\u00e9 d'Auvergne Clermont\u2010Ferrand France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"N.","family":"Baiz","sequence":"additional","affiliation":[{"name":"INSERM Equipe Epid\u00e9miologie des allergies et des maladies respiratoires UMR\u2010S 707 Paris France"},{"name":"EPAR Facult\u00e9 de M\u00e9decine Saint\u2010Antoine UPMC Paris France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"S.","family":"Banerjee","sequence":"additional","affiliation":[{"name":"INSERM Equipe Epid\u00e9miologie des allergies et des maladies respiratoires UMR\u2010S 707 Paris France"},{"name":"EPAR Facult\u00e9 de M\u00e9decine Saint\u2010Antoine UPMC Paris France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"D.","family":"Charpin","sequence":"additional","affiliation":[{"name":"Service de Pneumologie CHU Marseille France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"F.","family":"Lavaud","sequence":"additional","affiliation":[{"name":"Service de Pneumologie CHU Reims France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"F.","family":"de Blay","sequence":"additional","affiliation":[{"name":"Service de Pneumologie CHU Strasbourg France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"C.","family":"Raherison","sequence":"additional","affiliation":[{"name":"Service de Pneumologie CHU Bordeaux France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"I.","family":"Annesi\u2010Maesano","sequence":"additional","affiliation":[{"name":"INSERM Equipe Epid\u00e9miologie des allergies et des maladies respiratoires UMR\u2010S 707 Paris France"},{"name":"EPAR Facult\u00e9 de M\u00e9decine Saint\u2010Antoine UPMC Paris France"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2014,5,24]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2007.02.041"},{"key":"e_1_2_9_3_1","doi-asserted-by":"crossref","first-page":"666","DOI":"10.1016\/0091-6749(84)90302-6","article-title":"Methods of exercise challenge","volume":"73","author":"Eggleston PA","year":"1984","journal-title":"J Allergy Clin Immunol"},{"key":"e_1_2_9_4_1","doi-asserted-by":"crossref","first-page":"S94","DOI":"10.1016\/j.jaci.2007.09.029","article-title":"Expert panel report 3 (epr\u20103): guidelines for the diagnosis and management of asthma\u2010summary report 2007","volume":"120","author":"National Heart, Lung and Blood Institute, National Asthma Education and Prevention program","year":"2007","journal-title":"J Allergy Clin Immunol"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1136\/thx.2005.045682"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1136\/thx.46.6.405"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1136\/bjsports-2011-090810"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199405123301907"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.1378\/chest.105.4.1127"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1399-3038.2005.00327.x"},{"key":"e_1_2_9_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0301-0546(04)79266-6"},{"key":"e_1_2_9_12_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1398-9995.2009.02210.x"},{"key":"e_1_2_9_13_1","doi-asserted-by":"publisher","DOI":"10.1136\/thoraxjnl-2011-200391"},{"key":"e_1_2_9_14_1","doi-asserted-by":"publisher","DOI":"10.1034\/j.1398-9995.2002.1o3170.x"},{"key":"e_1_2_9_15_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2222.2011.03832.x"},{"key":"e_1_2_9_16_1","doi-asserted-by":"publisher","DOI":"10.1164\/rccm.200703-427OC"},{"key":"e_1_2_9_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(08)61446-4"},{"key":"e_1_2_9_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0091-6749(99)70370-2"},{"key":"e_1_2_9_19_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1398-9995.2007.01620.x"},{"key":"e_1_2_9_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/0091-6749(76)90188-3"},{"key":"e_1_2_9_21_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1398-9995.1995.tb02497.x"},{"key":"e_1_2_9_22_1","first-page":"278","article-title":"Exercise\u2010induced bronchoconstriction in rhinitis children without asthma","volume":"29","author":"Rakkhong K","year":"2011","journal-title":"Asian Pac J Allergy Immunol"},{"key":"e_1_2_9_23_1","doi-asserted-by":"publisher","DOI":"10.1164\/ajrccm\/147.5.1112"},{"key":"e_1_2_9_24_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0091-6749(98)70329-X"},{"key":"e_1_2_9_25_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0091-6749(05)80215-5"},{"key":"e_1_2_9_26_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.0905-6157.2003.00067.x"},{"key":"e_1_2_9_27_1","doi-asserted-by":"crossref","first-page":"851","DOI":"10.1542\/peds.56.5S.851","article-title":"Exercise\u2010induced bronchial lability in wheezy children and their families","volume":"56","author":"Godfrey S","year":"1975","journal-title":"Pediatrics"},{"key":"e_1_2_9_28_1","first-page":"73","article-title":"Effect of exercise on pulmonary function tests in normal first degree relations of asthmatic subjects","volume":"33","author":"Jain AK","year":"1991","journal-title":"Indian J Chest Dis Allied Sci"},{"key":"e_1_2_9_29_1","first-page":"73","article-title":"Bronchial responsiveness in normal first\u2010degree relatives of asthmatics and patients of allergic rhinitis","volume":"33","author":"Daga M","year":"2007","journal-title":"J Indian Acad Clin Med"},{"key":"e_1_2_9_30_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2008.05.001"},{"key":"e_1_2_9_31_1","doi-asserted-by":"publisher","DOI":"10.1067\/mai.2001.113046"},{"key":"e_1_2_9_32_1","doi-asserted-by":"crossref","first-page":"1488","DOI":"10.1183\/09031936.95.08091488","article-title":"Effect of regular inhaled beclomethasone on exercise and methacholine airway responses in school children with recurrent wheeze","volume":"8","author":"Freezer NJ","year":"1995","journal-title":"Eur Respir J"},{"key":"e_1_2_9_33_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0091-6749(96)70150-1"},{"key":"e_1_2_9_34_1","doi-asserted-by":"publisher","DOI":"10.1034\/j.1399-3038.2002.01051.x"},{"key":"e_1_2_9_35_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2004.04.042"},{"key":"e_1_2_9_36_1","doi-asserted-by":"publisher","DOI":"10.1164\/ajrccm.159.6.9805093"},{"key":"e_1_2_9_37_1","doi-asserted-by":"publisher","DOI":"10.1002\/ppul.1950170509"},{"key":"e_1_2_9_38_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2005.05.025"},{"key":"e_1_2_9_39_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pmed.0040070"},{"key":"e_1_2_9_40_1","doi-asserted-by":"publisher","DOI":"10.1164\/ajrccm.154.6.8970347"},{"key":"e_1_2_9_41_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1398-9995.1986.tb00335.x"},{"key":"e_1_2_9_42_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1081-1206(10)62963-8"},{"key":"e_1_2_9_43_1","doi-asserted-by":"publisher","DOI":"10.1136\/adc.49.12.923"},{"key":"e_1_2_9_44_1","doi-asserted-by":"publisher","DOI":"10.1136\/adc.64.10.1452"},{"key":"e_1_2_9_45_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(01)06521-7"},{"key":"e_1_2_9_46_1","doi-asserted-by":"publisher","DOI":"10.1002\/ppul.22620"},{"key":"e_1_2_9_47_1","doi-asserted-by":"publisher","DOI":"10.1136\/thx.53.11.919"},{"key":"e_1_2_9_48_1","doi-asserted-by":"crossref","first-page":"161","DOI":"10.1136\/thx.52.2.161","article-title":"Exercise induced bronchospasm in Ghana: differences in prevalence between urban and rural schoolchildren","volume":"52","author":"AddoYobo EO","year":"1997","journal-title":"Thorax"},{"key":"e_1_2_9_49_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2222.1979.tb02489.x"},{"key":"e_1_2_9_50_1","doi-asserted-by":"publisher","DOI":"10.1136\/thx.46.8.549"}],"container-title":["Clinical &amp; Experimental Allergy"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fcea.12310","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/cea.12310","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,3]],"date-time":"2023-10-03T04:04:51Z","timestamp":1696305891000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/cea.12310"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2014,5,24]]},"references-count":49,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2014,6]]}},"alternative-id":["10.1111\/cea.12310"],"URL":"https:\/\/doi.org\/10.1111\/cea.12310","archive":["Portico"],"relation":{},"ISSN":["0954-7894","1365-2222"],"issn-type":[{"value":"0954-7894","type":"print"},{"value":"1365-2222","type":"electronic"}],"subject":[],"published":{"date-parts":[[2014,5,24]]}}}