{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T22:18:13Z","timestamp":1790720293485,"version":"4.1.0"},"reference-count":37,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2014,12,26]],"date-time":"2014-12-26T00:00:00Z","timestamp":1419552000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"ALK"},{"name":"Glaxosmithkline world wide epidemiology"},{"DOI":"10.13039\/501100009772","name":"Norrbotten County Council","doi-asserted-by":"crossref","id":[{"id":"10.13039\/501100009772","id-type":"DOI","asserted-by":"crossref"}]},{"name":"Swedish Heart Lung Foundation"},{"name":"The Swedish Asthma and Allergy Associations Research Foundation"},{"name":"The Swedish Foundation for Health Care Science and Allergy Research (V\u00ef\u00bf\u00bdrdal)"},{"DOI":"10.13039\/501100001862","name":"The Swedish Research Council","doi-asserted-by":"crossref","id":[{"id":"10.13039\/501100001862","id-type":"DOI","asserted-by":"crossref"}]},{"name":"ThermoFisher"},{"name":"Visare Norr"},{"name":"V\u00ef\u00bf\u00bdsterbotten county council"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Clin Experimental Allergy"],"published-print":{"date-parts":[[2015,1]]},"abstract":"<jats:title>Summary<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Asthma is common among adolescents, but there are few population\u2010based studies on the risk factors for incident asthma and wheeze at this age group.<\/jats:p><\/jats:sec><jats:sec><jats:title>Objective<\/jats:title><jats:p>To study risk factors for incident asthma and wheeze in adolescence.<\/jats:p><\/jats:sec><jats:sec><jats:title>Method<\/jats:title><jats:p>Within the Obstructive Lung Disease In Northern Sweden (<jats:styled-content style=\"fixed-case\">OLIN<\/jats:styled-content>) studies, a cohort of 3430 school children (age 7\u20138\u00a0year) was recruited in 1996. In the present study, this cohort was followed from age 12\u201319\u00a0year. At baseline (age 12\u00a0year), 3151 participated and skin prick tests (<jats:styled-content style=\"fixed-case\">SPT<\/jats:styled-content>) were performed. The cohort was resurveyed annually, and risk factors for the cumulative incidence of asthma and wheeze from age 12\u201319\u00a0year were analysed using multivariate Cox regression.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Female sex (wheeze: <jats:styled-content style=\"fixed-case\">HR<\/jats:styled-content> 1.4 95%<jats:styled-content style=\"fixed-case\">CI<\/jats:styled-content> 1.2\u20131.6; asthma: <jats:styled-content style=\"fixed-case\">HR<\/jats:styled-content> 1.8 95%<jats:styled-content style=\"fixed-case\">CI<\/jats:styled-content> 1.2\u20132.5) and a positive <jats:styled-content style=\"fixed-case\">SPT<\/jats:styled-content> to cat, dog or horse at baseline (wheeze: <jats:styled-content style=\"fixed-case\">HR<\/jats:styled-content> 1.6 95%<jats:styled-content style=\"fixed-case\">CI<\/jats:styled-content> 1.2\u20132.1; asthma: <jats:styled-content style=\"fixed-case\">HR<\/jats:styled-content> 2.3 95%<jats:styled-content style=\"fixed-case\">CI<\/jats:styled-content> 1.4\u20134.0) were significantly associated with the cumulative incidence of wheeze and asthma. Increasing numbers of siblings were inversely related to the incidence of wheeze (<jats:styled-content style=\"fixed-case\">HR<\/jats:styled-content> 0.9 95%<jats:styled-content style=\"fixed-case\">CI<\/jats:styled-content> 0.8\u20130.97) and asthma (<jats:styled-content style=\"fixed-case\">HR<\/jats:styled-content> 0.8 95%<jats:styled-content style=\"fixed-case\">CI<\/jats:styled-content> 0.7\u20130.97). Parental asthma was related to the incidence of asthma (<jats:styled-content style=\"fixed-case\">HR<\/jats:styled-content> 1.8 95%<jats:styled-content style=\"fixed-case\">CI<\/jats:styled-content> 1.2\u20132.6) while ever smoking (<jats:styled-content style=\"fixed-case\">HR<\/jats:styled-content> 2.0 95%<jats:styled-content style=\"fixed-case\">CI<\/jats:styled-content> 1.6\u20132.4) and house dampness (<jats:styled-content style=\"fixed-case\">HR<\/jats:styled-content> 1.3 95%<jats:styled-content style=\"fixed-case\">CI<\/jats:styled-content> 1.1\u20131.6) were risk factors for the incidence of wheeze. Maternal <jats:styled-content style=\"fixed-case\">ETS<\/jats:styled-content> exposure increased the risk of incident asthma in non\u2010sensitized subjects (<jats:styled-content style=\"fixed-case\">HR<\/jats:styled-content> 1.9 95%<jats:styled-content style=\"fixed-case\">CI<\/jats:styled-content> 1.0\u20133.7).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion and clinical relevance<\/jats:title><jats:p>Several environmental risk factors related to the incidence of asthma and wheeze in adolescence were identified and may be possible targets for intervention and prevention.<\/jats:p><\/jats:sec>","DOI":"10.1111\/cea.12335","type":"journal-article","created":{"date-parts":[[2014,4,28]],"date-time":"2014-04-28T16:30:22Z","timestamp":1398702622000},"page":"184-191","source":"Crossref","is-referenced-by-count":18,"title":["Environmental risk factors related to the incidence of wheeze and asthma in adolescence"],"prefix":"10.1111","volume":"45","author":[{"given":"L.","family":"Hedman","sequence":"first","affiliation":[{"name":"Department of Public Health and Clinical Medicine Division for Occupational and Environmental Medicine The OLIN Unit Ume\u00e5 University Ume\u00e5 Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M.","family":"Andersson","sequence":"additional","affiliation":[{"name":"Department of Public Health and Clinical Medicine Division for Occupational and Environmental Medicine The OLIN Unit Ume\u00e5 University Ume\u00e5 Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A.","family":"Bjerg","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine and Clinical Nutrition Krefting Research Centre University of Gothenburg Gothenburg Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"B.","family":"Forsberg","sequence":"additional","affiliation":[{"name":"Department of Public Health and Clinical Medicine Division for Occupational and Environmental Medicine The OLIN Unit Ume\u00e5 University Ume\u00e5 Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"B.","family":"Lundb\u00e4ck","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine and Clinical Nutrition Krefting Research Centre University of Gothenburg Gothenburg Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"E.","family":"R\u00f6nmark","sequence":"additional","affiliation":[{"name":"Department of Public Health and Clinical Medicine Division for Occupational and Environmental Medicine The OLIN Unit Ume\u00e5 University Ume\u00e5 Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2014,12,26]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1136\/thx.47.7.537"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1398-9995.1998.tb03770.x"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1136\/thx.2005.051227"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(08)61447-6"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2008.05.018"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1034\/j.1399-3038.2003.00047.x"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1186\/2045-7022-2-1"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2007.07.020"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1378\/chest.127.6.1928"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.1093\/aje\/kwr484"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2222.2012.04056.x"},{"key":"e_1_2_7_13_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM200008243430803"},{"key":"e_1_2_7_14_1","doi-asserted-by":"publisher","DOI":"10.1289\/ehp.0901232"},{"key":"e_1_2_7_15_1","doi-asserted-by":"publisher","DOI":"10.1097\/00001648-200205000-00009"},{"key":"e_1_2_7_16_1","doi-asserted-by":"publisher","DOI":"10.1136\/thx.50.3.260"},{"key":"e_1_2_7_17_1","doi-asserted-by":"publisher","DOI":"10.1053\/rmed.2002.1391"},{"key":"e_1_2_7_18_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1398-9995.2006.01027.x"},{"key":"e_1_2_7_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2009.05.011"},{"key":"e_1_2_7_20_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1752-699X.2008.00081.x"},{"key":"e_1_2_7_21_1","doi-asserted-by":"publisher","DOI":"10.1183\/09031936.95.08030483"},{"key":"e_1_2_7_22_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jclinepi.2009.08.017"},{"key":"e_1_2_7_23_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1399-3038.2005.00231.x"},{"issue":"10","key":"e_1_2_7_24_1","first-page":"1","article-title":"Skin tests used in type 1 allergy testing. 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