{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,30]],"date-time":"2026-04-30T02:58:00Z","timestamp":1777517880253,"version":"3.51.4"},"reference-count":39,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2014,12,26]],"date-time":"2014-12-26T00:00:00Z","timestamp":1419552000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100003793","name":"Hj\u00e4rt-Lungfonden","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100003793","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Astma- och allergif\u00ef\u00bf\u00bdrbundet"},{"name":"VBG group"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Clin Experimental Allergy"],"published-print":{"date-parts":[[2015,1]]},"abstract":"<jats:title>Summary<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Population\u2010based studies on aspirin\u2010intolerant asthma (AIA) are very few, and no previous population study has investigated risk factors for the condition.<\/jats:p><\/jats:sec><jats:sec><jats:title>Objective<\/jats:title><jats:p>To investigate the prevalence and risk factors of AIA in the general population.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>A questionnaire on respiratory health was mailed to 30\u00a0000 randomly selected subjects aged 16\u201375\u00a0years in West Sweden, 29\u00a0218 could be traced and 18\u00a0087 (62%) responded. The questionnaire included questions on asthma, respiratory symptoms, aspirin\u2010induced dyspnoea and possible determinants.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The prevalence of AIA was 0.5%, 0.3% in men and 0.6% in women (<jats:italic>P<\/jats:italic>\u00a0=\u00a00.014). Sick leave, emergency visits due to asthma and all investigated lower respiratory symptoms were more common in AIA than in aspirin\u2010tolerant asthma (ATA). Obesity was a strong risk factor for AIA (<jats:styled-content style=\"fixed-case\">BMI<\/jats:styled-content> &gt;\u00a035: odds ratio (<jats:styled-content style=\"fixed-case\">OR<\/jats:styled-content>) 12.1; 95% <jats:styled-content style=\"fixed-case\">CI<\/jats:styled-content> 2.49\u201358.5), and there was a dose\u2010response relationship between increasing body mass index (BMI) and risk of AIA. Obesity, airborne occupational exposure and visible mould at home were considerably stronger risk factors for AIA than for ATA. Current smoking was a risk factor for AIA (<jats:styled-content style=\"fixed-case\">OR<\/jats:styled-content> 2.55; 95% <jats:styled-content style=\"fixed-case\">CI<\/jats:styled-content> 1.47\u20134.42), but not ATA.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Aspirin\u2010intolerant asthma identified in the general population was associated with a high burden of symptoms, uncontrolled disease and a high morbidity. Increasing BMI increased the risk of AIA in a dose\u2010response manner. A number of risk factors, including obesity and current smoking, were considerably stronger for AIA than for ATA.<\/jats:p><\/jats:sec>","DOI":"10.1111\/cea.12359","type":"journal-article","created":{"date-parts":[[2014,6,24]],"date-time":"2014-06-24T20:10:10Z","timestamp":1403640610000},"page":"211-219","source":"Crossref","is-referenced-by-count":20,"title":["Aspirin\u2010intolerant asthma in the population: prevalence and important determinants"],"prefix":"10.1111","volume":"45","author":[{"given":"J.","family":"Eriksson","sequence":"first","affiliation":[{"name":"Department of Internal Medicine and Clinical Nutrition Sahlgrenska Academy University of Gothenburg Gothenburg Sweden"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"L.","family":"Ekerljung","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine and Clinical Nutrition Sahlgrenska Academy University of Gothenburg Gothenburg 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