{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,14]],"date-time":"2026-04-14T16:43:42Z","timestamp":1776185022956,"version":"3.50.1"},"reference-count":42,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2014,9,22]],"date-time":"2014-09-22T00:00:00Z","timestamp":1411344000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Clin Experimental Allergy"],"published-print":{"date-parts":[[2014,10]]},"abstract":"<jats:title>Summary<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Adherence to controller therapy in allergic diseases is low. Telemonitoring has been proposed to improve adherence to treatment in chronic diseases. However, this strategy has never been tested in allergic rhinoconjunctivitis.<\/jats:p><\/jats:sec><jats:sec><jats:title>Objective<\/jats:title><jats:p>To test whether Internet\u2010based telemonitoring during the grass\u2010pollen season of children with allergic rhinoconjunctivitis may enhance adherence to treatment.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Children and adolescents, 5\u201318\u00a0years old, with moderate\u2010to\u2010severe seasonal allergic rhinoconjunctivitis to grass pollen requiring daily administration of nasal corticosteroid (<jats:styled-content style=\"fixed-case\">NCS<\/jats:styled-content>) (mometasone) were recruited (<jats:styled-content style=\"fixed-case\">A<\/jats:styled-content>pril 2013) in a paediatric allergy practice. Participants were randomized to Internet\u2010based monitoring (<jats:styled-content style=\"fixed-case\">A<\/jats:styled-content>llergy<jats:styled-content style=\"fixed-case\">M<\/jats:styled-content>onitor<jats:sup>\u2122<\/jats:sup>, <jats:styled-content style=\"fixed-case\">AM<\/jats:styled-content>) or to usual care (no diary at all, controls) and followed from 13 <jats:styled-content style=\"fixed-case\">M<\/jats:styled-content>ay (<jats:styled-content style=\"fixed-case\">T<\/jats:styled-content>0) to 15 <jats:styled-content style=\"fixed-case\">J<\/jats:styled-content>une 2013 (<jats:styled-content style=\"fixed-case\">T<\/jats:styled-content>2). An intermediate visit (<jats:styled-content style=\"fixed-case\">T<\/jats:styled-content>1) was performed between 31 <jats:styled-content style=\"fixed-case\">M<\/jats:styled-content>ay and 2 June. Optimal adherence to therapy was expressed as the use of at least 0.190\u00a0g\/day of mometasone, corresponding to 1\u00a0puff\/nostril\/day, and it was measured by canister weights during (<jats:styled-content style=\"fixed-case\">T<\/jats:styled-content>1) and at the end (<jats:styled-content style=\"fixed-case\">T<\/jats:styled-content>2) of the study period. Main secondary outcomes included the reported disease severity (validated self\u2010questionnaire) and quality of life (<jats:styled-content style=\"fixed-case\">A<\/jats:styled-content>do<jats:styled-content style=\"fixed-case\">IRQLQ<\/jats:styled-content> questionnaire), disease knowledge (multiple\u2010choice questionnaire), nasal flow and resistance at baseline and at <jats:styled-content style=\"fixed-case\">T<\/jats:styled-content>2.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The use of mometasone, expressed as both optimal adherence rate (48.4% vs. 12.5%; <jats:italic>P<\/jats:italic>\u00a0=\u00a00.002) and average daily use (0.20\u00a0\u00b1\u00a00.12\u00a0g\/day vs. 0.15\u00a0\u00b1\u00a00.07\u00a0g\/day; <jats:italic>P<\/jats:italic>\u00a0=\u00a00.037), was higher in the <jats:styled-content style=\"fixed-case\">AM<\/jats:styled-content> group (<jats:italic>n<\/jats:italic>\u00a0=\u00a031) than among controls (<jats:italic>n<\/jats:italic>\u00a0=\u00a032). Disease knowledge improved among the patients using <jats:styled-content style=\"fixed-case\">AM<\/jats:styled-content> (83.3% vs. 68.3%; <jats:italic>P<\/jats:italic>\u00a0&lt;\u00a00.001) but not among controls (68.2% vs. 67.7% right answers; <jats:italic>P<\/jats:italic>\u00a0&gt;\u00a00.05). No differences were observed in the reported severity of disease, nasal flow and resistance and quality of life both at baseline and at follow\u2010up visits.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Internet\u2010based telemonitoring improves adherence to <jats:styled-content style=\"fixed-case\">NCS<\/jats:styled-content> treatment and disease knowledge among children and adolescents with seasonal allergic rhinoconjunctivitis.<\/jats:p><\/jats:sec>","DOI":"10.1111\/cea.12386","type":"journal-article","created":{"date-parts":[[2014,8,8]],"date-time":"2014-08-08T18:07:44Z","timestamp":1407521264000},"page":"1246-1254","source":"Crossref","is-referenced-by-count":58,"title":["The impact of telemonitoring on adherence to nasal corticosteroid treatment in children with seasonal allergic rhinoconjunctivitis"],"prefix":"10.1111","volume":"44","author":[{"given":"A.","family":"Pizzulli","sequence":"first","affiliation":[{"name":"Department of Paediatric Pneumology and Immunology Charit\u00e9 Medical University Berlin Germany"},{"name":"Practice for Pediatric Allergy and Pneumology Berlin Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"S.","family":"Perna","sequence":"additional","affiliation":[{"name":"Department of Paediatric Pneumology and Immunology Charit\u00e9 Medical University Berlin Germany"},{"name":"Department of Statistical Sciences University \u2018La Sapienza\u2019 Rome Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J.","family":"Florack","sequence":"additional","affiliation":[{"name":"Department of Paediatric Pneumology and Immunology Charit\u00e9 Medical University Berlin Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A.","family":"Pizzulli","sequence":"additional","affiliation":[{"name":"Practice for Pediatric Allergy and Pneumology Berlin Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"P.","family":"Giordani","sequence":"additional","affiliation":[{"name":"Department of Statistical Sciences University \u2018La Sapienza\u2019 Rome Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"S.","family":"Tripodi","sequence":"additional","affiliation":[{"name":"Pediatric Department and Pediatric Allergology Unit SandroPertini Hospital Rome Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"S.","family":"Pelosi","sequence":"additional","affiliation":[{"name":"TPS Production srl Rome Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"P. M.","family":"Matricardi","sequence":"additional","affiliation":[{"name":"Department of Paediatric Pneumology and Immunology Charit\u00e9 Medical University Berlin Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2014,9,22]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1440-1754.2010.01779.x"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.2500\/ajra.2013.27.3965"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2009.05.013"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.2165\/00019053-200422060-00002"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.2500\/aap.2007.28.3013"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1398-9995.2006.01057.x"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2010.06.047"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1398-9995.2010.02439.x"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2009.10.064"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2012.07.053"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.1159\/000355953"},{"key":"e_1_2_7_13_1","first-page":"16","article-title":"Insights on allergic rhinoconjunctivitis from the patient perspective","volume":"61","author":"Fromer LM","year":"2012","journal-title":"J Fam Pract"},{"key":"e_1_2_7_14_1","doi-asserted-by":"publisher","DOI":"10.2147\/PROM.S19195"},{"key":"e_1_2_7_15_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.38875.675486.55"},{"key":"e_1_2_7_16_1","doi-asserted-by":"publisher","DOI":"10.1186\/1745-6215-14-431"},{"key":"e_1_2_7_17_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11096-013-9862-0"},{"key":"e_1_2_7_18_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.mlr.0000163641.86870.af"},{"key":"e_1_2_7_19_1","doi-asserted-by":"publisher","DOI":"10.18553\/jmcp.2014.20.1.22"},{"key":"e_1_2_7_20_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1755-6686.2013.12037.x"},{"key":"e_1_2_7_21_1","doi-asserted-by":"publisher","DOI":"10.1097\/ACI.0b013e32832b4651"},{"key":"e_1_2_7_22_1","doi-asserted-by":"publisher","DOI":"10.4065\/mcp.2010.0575"},{"key":"e_1_2_7_23_1","doi-asserted-by":"publisher","DOI":"10.1136\/adc.2009.175125"},{"key":"e_1_2_7_24_1","doi-asserted-by":"publisher","DOI":"10.1186\/1472-6963-8-75"},{"key":"e_1_2_7_25_1","doi-asserted-by":"crossref","first-page":"418","DOI":"10.1542\/peds.2013-0684","article-title":"Improving outcomes for underserved adolescents with asthma","volume":"133","author":"Britto MT","year":"2014","journal-title":"Pediatrics"},{"key":"e_1_2_7_26_1","doi-asserted-by":"publisher","DOI":"10.2500\/aap.2011.32.3455"},{"key":"e_1_2_7_27_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2222.2012.04052.x"},{"key":"e_1_2_7_28_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.326.7402.1308"},{"key":"e_1_2_7_29_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2009.01.053"},{"key":"e_1_2_7_30_1","doi-asserted-by":"publisher","DOI":"10.1089\/ped.2012.0150"},{"key":"e_1_2_7_31_1","doi-asserted-by":"publisher","DOI":"10.1164\/rccm.201003-0429OC"},{"key":"e_1_2_7_32_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.d120"},{"key":"e_1_2_7_33_1","doi-asserted-by":"publisher","DOI":"10.1258\/jtt.2012.120219"},{"key":"e_1_2_7_34_1","doi-asserted-by":"publisher","DOI":"10.1002\/14651858.CD007717.pub2"},{"key":"e_1_2_7_35_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.e1756"},{"key":"e_1_2_7_36_1","doi-asserted-by":"publisher","DOI":"10.1542\/peds.2006-1884"},{"key":"e_1_2_7_37_1","doi-asserted-by":"publisher","DOI":"10.1089\/tmj.2011.0218"},{"key":"e_1_2_7_38_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2222.2007.02708.x"},{"key":"e_1_2_7_39_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2222.2011.03734.x"},{"key":"e_1_2_7_40_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0091-6749(98)70380-X"},{"key":"e_1_2_7_41_1","doi-asserted-by":"publisher","DOI":"10.1590\/S1806-37132008000800012"},{"key":"e_1_2_7_42_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1399-3038.2012.01317.x"},{"key":"e_1_2_7_43_1","doi-asserted-by":"publisher","DOI":"10.1159\/000356317"}],"container-title":["Clinical &amp; Experimental Allergy"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fcea.12386","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/cea.12386","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,3]],"date-time":"2023-10-03T08:31:07Z","timestamp":1696321867000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/cea.12386"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2014,9,22]]},"references-count":42,"journal-issue":{"issue":"10","published-print":{"date-parts":[[2014,10]]}},"alternative-id":["10.1111\/cea.12386"],"URL":"https:\/\/doi.org\/10.1111\/cea.12386","archive":["Portico"],"relation":{},"ISSN":["0954-7894","1365-2222"],"issn-type":[{"value":"0954-7894","type":"print"},{"value":"1365-2222","type":"electronic"}],"subject":[],"published":{"date-parts":[[2014,9,22]]}}}