{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,25]],"date-time":"2026-03-25T05:59:53Z","timestamp":1774418393175,"version":"3.50.1"},"reference-count":35,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2014,10,21]],"date-time":"2014-10-21T00:00:00Z","timestamp":1413849600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Clin Experimental Allergy"],"published-print":{"date-parts":[[2014,11]]},"abstract":"<jats:title>Summary<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Atopy is the familial or personal propensity to develop immunoglobulin E (IgE) antibodies against common environmental allergens and is associated with high risk of allergic disease. It has been proposed that atopy may have effects on risk of cardiovascular disease and cancer.<\/jats:p><\/jats:sec><jats:sec><jats:title>Objectives<\/jats:title><jats:p>We investigated the association of atopy with all\u2010cause and cause\u2010specific mortality.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We included a total of 14\u00a0849 individuals from five Danish population\u2010based cohorts with measurements of atopy defined as serum\u2010specific IgE positivity against inhalant allergens. Participants were followed by linkage to the Danish Registry of Causes of Death to obtain information on mortality status and cause of death (median follow\u2010up time 11.3\u00a0years). The relative mortality risk was estimated by Cox regression and expressed as hazard ratios, HRs (95% confidence intervals, CIs).<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>A total of 1776 person died during follow\u2010up. The mortality risk for atopics vs. non\u2010atopics was: for all\u2010cause mortality (HR\u00a0=\u00a01.03, 95% CI: 0.90, 1.17); neoplasms (HR\u00a0=\u00a00.86, 95% CI: 0.69, 1.06); endocrine, nutritional and metabolic disorders (HR\u00a0=\u00a01.48, 95% CI: 0.71, 3.08); mental and behavioural disorders (HR\u00a0=\u00a02.26, 95% CI: 1.18, 4.30); diseases of the nervous system (HR\u00a0=\u00a01.36, 95% CI: 0.65, 2.87); diseases of the circulatory system (HR\u00a0=\u00a01.00, 95% CI: 0.78, 1.29); diseases of the respiratory system (HR\u00a0=\u00a00.94, 95% CI: 0.55, 1.60); and diseases of the digestive system (HR\u00a0=\u00a01.75, 95% CI: 1.03, 2.98).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions &amp; Clinical Relevance<\/jats:title><jats:p>We found no statistically significant association between atopy and all\u2010cause mortality. However, atopy was associated with a significantly higher risk of dying from mental and behavioural disorders and gastrointestinal diseases, particularly liver diseases, and a lower risk of dying from breast cancer, but these associations were not statistically significant when applying the Bonferroni adjusted significance level. Further studies are needed to confirm our findings.<\/jats:p><\/jats:sec>","DOI":"10.1111\/cea.12408","type":"journal-article","created":{"date-parts":[[2014,9,15]],"date-time":"2014-09-15T02:45:13Z","timestamp":1410749113000},"page":"1361-1370","source":"Crossref","is-referenced-by-count":16,"title":["Atopy and cause\u2010specific mortality"],"prefix":"10.1111","volume":"44","author":[{"given":"T.","family":"Skaaby","sequence":"first","affiliation":[{"name":"Research Centre for Prevention and Health Glostrup University Hospital Glostrup Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"L. L. 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H.","family":"Thuesen","sequence":"additional","affiliation":[{"name":"Research Centre for Prevention and Health Glostrup University Hospital Glostrup Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"L.","family":"Hammer\u2010Helmich","sequence":"additional","affiliation":[{"name":"Research Centre for Prevention and Health Glostrup University Hospital Glostrup Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A.","family":"Linneberg","sequence":"additional","affiliation":[{"name":"Research Centre for Prevention and Health Glostrup University Hospital Glostrup Denmark"},{"name":"Department of Clinical Experimental Research Glostrup University Hospital Glostrup Denmark"},{"name":"Department of Clinical Medicine Faculty of Health and Medical Sciences University of Copenhagen Copenhagen Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2014,10,21]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2003.12.591"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.immuni.2012.07.007"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.gtc.2008.02.003"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1590-8658(00)80354-0"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1186\/1465-9921-14-10"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10552-009-9334-y"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1398-9995.2005.00813.x"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2009.10.045"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1159\/000112729"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jad.2013.11.009"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.1093\/ije\/dyq041"},{"key":"e_1_2_7_13_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.hjr.0000096541.30533.82"},{"key":"e_1_2_7_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2011.08.045"},{"key":"e_1_2_7_15_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1530-0277.2008.00780.x"},{"key":"e_1_2_7_16_1","doi-asserted-by":"publisher","DOI":"10.1080\/14034940600607616"},{"key":"e_1_2_7_17_1","doi-asserted-by":"publisher","DOI":"10.1159\/000236004"},{"key":"e_1_2_7_18_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1398-9995.2006.00968.x"},{"key":"e_1_2_7_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.clinbiochem.2004.06.010"},{"key":"e_1_2_7_20_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1398-9995.2010.02378.x"},{"key":"e_1_2_7_21_1","first-page":"354","article-title":"The Danish registers of causes of death","volume":"46","author":"Juel K","year":"1999","journal-title":"Dan Med Bull"},{"key":"e_1_2_7_22_1","doi-asserted-by":"publisher","DOI":"10.1177\/1403494810387965"},{"key":"e_1_2_7_23_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12020-014-0321-z"},{"key":"e_1_2_7_24_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2222.2000.00971.x"},{"key":"e_1_2_7_25_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1398-9995.1995.tb01212.x"},{"key":"e_1_2_7_26_1","first-page":"161","article-title":"Cancer incidence in 13811 patients skin tested for allergy","volume":"15","author":"Eriksson NE","year":"2005","journal-title":"J Investig Allergol Clin Immunol"},{"key":"e_1_2_7_27_1","first-page":"1709","article-title":"Breast cancer risk in relation to most prevalent IgE specific antibodies: a case control study in Greece","volume":"27","author":"Petridou ET","year":"2007","journal-title":"Anticancer Res"},{"key":"e_1_2_7_28_1","doi-asserted-by":"publisher","DOI":"10.1002\/ijc.21883"},{"key":"e_1_2_7_29_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0068582"},{"key":"e_1_2_7_30_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0027912"},{"key":"e_1_2_7_31_1","doi-asserted-by":"publisher","DOI":"10.1586\/17474124.2014.881716"},{"key":"e_1_2_7_32_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1530-0277.2008.00655.x"},{"key":"e_1_2_7_33_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2222.2003.01515.x"},{"key":"e_1_2_7_34_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10654-010-9427-7"},{"key":"e_1_2_7_35_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.ede.0000220549.14177.60"},{"key":"e_1_2_7_36_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.b2393"}],"container-title":["Clinical &amp; 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