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The study of potential predictive biomarkers in various media, ranging from invasive sampling (e.g. bronchoscopy) to non\u2010invasive sampling (lung function testing and exhaled breath analysis), was comprehensively reviewed. The evolution in biomarker discovery has resulted in an \u2018omics\u2019 approach, in which hundreds of biomarkers in the field of genomics, proteomics, metabolomics, and \u2018breath\u2010omics\u2019 can be simultaneously studied. First, results on gene expression and exhaled breath profiles in predicting an early asthma diagnosis are promising. However, many hurdles need to be overcome before clinical implementation is possible. To reliably predict asthma in a wheezing child, probably a holistic approach is needed, combining clinical information with blood sampling, lung function tests, and potentially exhaled breath analysis. The further development of predictive, non\u2010invasive biomarkers may eventually improve an early asthma diagnosis in wheezing preschool children and assist clinicians in early treatment decision\u2010making.<\/jats:p>","DOI":"10.1111\/cea.12460","type":"journal-article","created":{"date-parts":[[2014,11,20]],"date-time":"2014-11-20T07:38:32Z","timestamp":1416469112000},"page":"1040-1050","source":"Crossref","is-referenced-by-count":26,"title":["Biomarkers to predict asthma in wheezing preschool children"],"prefix":"10.1111","volume":"45","author":[{"given":"M. A. G. E.","family":"Bannier","sequence":"first","affiliation":[{"name":"Department of Paediatric Respiratory Medicine School for Public Health and Primary Care (CAPHRI) Maastricht University Medical Centre Maastricht The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"K. D. 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