{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,26]],"date-time":"2026-08-26T23:15:23Z","timestamp":1787786123890,"version":"build-2784847793"},"reference-count":53,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2015,10,15]],"date-time":"2015-10-15T00:00:00Z","timestamp":1444867200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100000272","name":"National Institute for Health Research","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100000272","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Clin Experimental Allergy"],"published-print":{"date-parts":[[2015,11]]},"abstract":"<jats:title>Summary<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Food allergy is a common cause of anaphylaxis, but the incidence of anaphylaxis in food allergic people is unknown.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We undertook a systematic review and meta\u2010analysis, using the inverse variance method. Two authors selected studies by consensus, independently extracted data and assessed study quality using the Newcastle\u2013Ottawa assessment scale. We searched Medline, Embase, PsychInfo, <jats:styled-content style=\"fixed-case\">CINAHL<\/jats:styled-content>, Web of Science, <jats:styled-content style=\"fixed-case\">LILACS<\/jats:styled-content> and <jats:styled-content style=\"fixed-case\">AMED<\/jats:styled-content> between January 1946 and September 2012 and recent conference abstracts. We included registries, databases or cohort studies which described the number of food anaphylaxis cases in a defined population and time period and applied an assumed population prevalence of food allergy.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>We included data from 34 studies. There was high heterogeneity between study results, possibly due to variation in study populations, anaphylaxis definition and data collection methods. In food allergic people, medically coded food anaphylaxis had an incidence rate of 0.14 per 100 person\u2010years (95% <jats:styled-content style=\"fixed-case\">CI<\/jats:styled-content> 0.05, 0.35; range 0.01, 1.28). In sensitivity analysis using different estimated food allergy prevalence, the incidence varied from 0.11 to 0.21 per 100 person\u2010years. At age 0\u201319, the incidence rate for anaphylaxis in food allergic people was 0.20 (95% <jats:styled-content style=\"fixed-case\">CI<\/jats:styled-content> 0.09, 0.43; range 0.01, 2.55; sensitivity analysis 0.08, 0.39). At age 0\u20134, an incidence rate of up to 7.00 per 100 person\u2010years has been reported. In food allergic people, hospital admission due to food anaphylaxis had an incidence rate of 0.09 (95% <jats:styled-content style=\"fixed-case\">CI<\/jats:styled-content> 0.01, 0.67; range 0.02, 0.81) per 1000 person\u2010years; 0.20 (95% <jats:styled-content style=\"fixed-case\">CI<\/jats:styled-content> 0.10, 0.43; range 0.04, 2.25) at age 0\u201319 and 0.50 (0.26, 0.93; range 0.08, 2.82) at age 0\u20134.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>In food allergic people, the incidence of food allergic reactions which are coded as anaphylaxis by healthcare systems is low at all ages, but appears to be highest in young children.<\/jats:p><\/jats:sec>","DOI":"10.1111\/cea.12477","type":"journal-article","created":{"date-parts":[[2014,12,11]],"date-time":"2014-12-11T15:36:42Z","timestamp":1418312202000},"page":"1621-1636","source":"Crossref","is-referenced-by-count":77,"title":["Incidence of food anaphylaxis in people with food allergy: a systematic review and meta\u2010analysis"],"prefix":"10.1111","volume":"45","author":[{"given":"T.","family":"Umasunthar","sequence":"first","affiliation":[{"name":"Department of Paediatrics Imperial College London UK"},{"name":"Imperial College Healthcare NHS Trust St Mary's Hospital London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J.","family":"Leonardi\u2010Bee","sequence":"additional","affiliation":[{"name":"Division of Epidemiology and Public Health University of Nottingham Nottingham UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"P. 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