{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,31]],"date-time":"2026-03-31T12:35:56Z","timestamp":1774960556676,"version":"3.50.1"},"reference-count":19,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2015,4,16]],"date-time":"2015-04-16T00:00:00Z","timestamp":1429142400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001804","name":"Canada Research Chairs program","doi-asserted-by":"crossref","id":[{"id":"10.13039\/501100001804","id-type":"DOI","asserted-by":"crossref"}]},{"name":"Canada Foundation for Innovation"},{"name":"McMaster University\/GSK Chair in Lung Immunology at St. Joseph's Healthcare"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Clin Experimental Allergy"],"published-print":{"date-parts":[[2015,5]]},"abstract":"<jats:title>Summary<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Cat\u2010<jats:styled-content style=\"fixed-case\">PAD<\/jats:styled-content>, the first in a new class of synthetic peptide immuno\u2010regulatory epitopes (<jats:styled-content style=\"fixed-case\">SPIRE<\/jats:styled-content>s), was shown to significantly improve rhinoconjunctivitis symptoms in subjects with cat allergy up to 1\u00a0year after the start of a short course of treatment.<\/jats:p><\/jats:sec><jats:sec><jats:title>Objective<\/jats:title><jats:p>To evaluate the long\u2010term effects of Cat\u2010<jats:styled-content style=\"fixed-case\">PAD<\/jats:styled-content> on rhinoconjunctivitis symptoms following standardized allergen challenge 2\u00a0years after treatment.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>In a randomized, double\u2010blind, placebo\u2010controlled, parallel group study, subjects were exposed to cat allergen in an environmental exposure chamber (<jats:styled-content style=\"fixed-case\">EEC<\/jats:styled-content>) before and after treatment with two regimens of Cat\u2010<jats:styled-content style=\"fixed-case\">PAD<\/jats:styled-content> (either eight doses of 3\u00a0nmol or four doses of 6\u00a0nmol) given intradermally over a 3\u2010month period. In this follow\u2010up study, changes from baseline in rhinoconjunctivitis symptoms were reassessed 2\u00a0years after the start of treatment.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The primary endpoint showed a mean reduction in total rhinoconjunctivitis symptom scores of 3.85 units in the 4\u00a0\u00d7\u00a06\u00a0nmol Cat\u2010<jats:styled-content style=\"fixed-case\">PAD<\/jats:styled-content> group compared to placebo 2\u00a0years after the start of treatment (<jats:italic>P<\/jats:italic>\u00a0=\u00a00.13), and this difference was statistically significant in the secondary endpoint at the end of day 4 when the cumulative allergen challenge was greatest (<jats:italic>P<\/jats:italic>\u00a0=\u00a00.02). Consistent reductions in nasal symptoms of between 2 and 3 units were observed for 4\u00a0\u00d7\u00a06\u00a0nmol Cat\u2010<jats:styled-content style=\"fixed-case\">PAD<\/jats:styled-content> compared to placebo between the 2 and 3\u00a0h time points on days 1\u20134 of <jats:styled-content style=\"fixed-case\">EEC<\/jats:styled-content> challenge at 2\u00a0years (<jats:italic>P<\/jats:italic>\u00a0&lt;\u00a00.05). The 8\u00a0\u00d7\u00a03\u00a0nmol dose did not show a meaningful effect in this study.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion and Clinical Relevance<\/jats:title><jats:p>A persistent, clinically meaningful reduction in rhinoconjunctivitis symptoms was observed on <jats:styled-content style=\"fixed-case\">EEC<\/jats:styled-content> challenge 2\u00a0years after the start of a short course of treatment with 4\u00a0\u00d7\u00a06\u00a0nmol Cat\u2010<jats:styled-content style=\"fixed-case\">PAD<\/jats:styled-content>. This study is the first to provide evidence of a long\u2010term therapeutic effect with this new class of <jats:styled-content style=\"fixed-case\">SPIRE<\/jats:styled-content>s.<\/jats:p><\/jats:sec>","DOI":"10.1111\/cea.12488","type":"journal-article","created":{"date-parts":[[2015,1,20]],"date-time":"2015-01-20T12:21:50Z","timestamp":1421756510000},"page":"974-981","source":"Crossref","is-referenced-by-count":105,"title":["Fel d 1\u2010derived synthetic peptide immuno\u2010regulatory epitopes show a long\u2010term treatment effect in cat allergic subjects"],"prefix":"10.1111","volume":"45","author":[{"given":"P.","family":"Couroux","sequence":"first","affiliation":[{"name":"Cetero Research Mississauga ON Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"D.","family":"Patel","sequence":"additional","affiliation":[{"name":"Cetero Research Mississauga ON Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"K.","family":"Armstrong","sequence":"additional","affiliation":[{"name":"Adiga Life Sciences Inc. Hamilton ON Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M.","family":"Larch\u00e9","sequence":"additional","affiliation":[{"name":"Clinical Immunology &amp; Allergy and Respirology Divisions Department of Medicine and Firestone Institute for Respiratory Health McMaster University Hamilton ON Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"R. P.","family":"Hafner","sequence":"additional","affiliation":[{"name":"Circassia Limited Oxford UK"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2015,4,16]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2007.07.056"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2005.05.017"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-3164.2010.00882.x"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2010.11.029"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1038\/nm1226"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2013.03.013"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199908123410702"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2011.12.973"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1177\/039463200301600111"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.1097\/MLG.0b013e31804f8141"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.1186\/2045-7022-2-8"},{"key":"e_1_2_7_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2012.07.028"},{"key":"e_1_2_7_14_1","doi-asserted-by":"publisher","DOI":"10.1067\/mai.2001.113672"},{"key":"e_1_2_7_15_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2222.2005.00099.x"},{"issue":"83","key":"e_1_2_7_16_1","first-page":"118","article-title":"An environmental exposure chamber \u2010specific rhinoconjunctivitis quality of life questionnaire: the symptoms of seasonal allergic rhinitis correlate with the quality of life of patients with ragweed allergy in the chamber","volume":"62","author":"Salapatek AM","year":"2007","journal-title":"Allergy"},{"key":"e_1_2_7_17_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2222.1997.tb01225.x"},{"key":"e_1_2_7_18_1","first-page":"A105","article-title":"Tolerability and efficacy of sublingual immunotherapy in cat allergic subjects studied in an environmental exposure chamber","volume":"107","author":"Patel D","year":"2011","journal-title":"Ann Allergy Asthma Immunol"},{"key":"e_1_2_7_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1081-1206(10)61243-4"},{"key":"e_1_2_7_20_1","doi-asserted-by":"publisher","DOI":"10.1517\/13543784.2013.827661"}],"container-title":["Clinical &amp; Experimental Allergy"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fcea.12488","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fcea.12488","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/cea.12488","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,24]],"date-time":"2023-09-24T16:58:30Z","timestamp":1695574710000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/cea.12488"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015,4,16]]},"references-count":19,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2015,5]]}},"alternative-id":["10.1111\/cea.12488"],"URL":"https:\/\/doi.org\/10.1111\/cea.12488","archive":["Portico"],"relation":{},"ISSN":["0954-7894","1365-2222"],"issn-type":[{"value":"0954-7894","type":"print"},{"value":"1365-2222","type":"electronic"}],"subject":[],"published":{"date-parts":[[2015,4,16]]}}}